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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1929 1
1937 1
1938 1
1939 1
1942 1
1943 1
1945 21
1946 94
1947 91
1948 93
1949 86
1950 90
1951 102
1952 119
1953 115
1954 113
1955 132
1956 124
1957 113
1958 129
1959 167
1960 188
1961 204
1962 206
1963 282
1964 339
1965 308
1966 245
1967 333
1968 404
1969 444
1970 413
1971 455
1972 728
1973 1082
1974 1238
1975 1339
1976 1326
1977 1434
1978 1640
1979 1828
1980 1783
1981 1889
1982 2004
1983 2197
1984 2631
1985 2729
1986 2657
1987 2659
1988 2738
1989 3102
1990 3243
1991 3215
1992 3318
1993 3221
1994 3561
1995 3627
1996 3823
1997 3959
1998 3808
1999 4116
2000 4555
2001 4822
2002 4962
2003 5363
2004 5786
2005 6708
2006 7123
2007 6978
2008 6880
2009 6732
2010 7377
2011 7809
2012 8221
2013 8342
2014 8194
2015 8491
2016 8058
2017 7760
2018 7783
2019 8012
2020 8382
2021 8106
2022 7581
2023 7185
2024 7463
2025 8298
2026 3516

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245,148 results

Results by year

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Page 1
Notch inhibitor: a promising carcinoma radiosensitizer.
Yu SD, Liu FY, Wang QR. Yu SD, et al. Asian Pac J Cancer Prev. 2012;13(11):5345-51. doi: 10.7314/apjcp.2012.13.11.5345. Asian Pac J Cancer Prev. 2012. PMID: 23317182 Free article. Review.
As such, Notch inhibitors are attractive therapeutic agents, although as for other anticancer agents, they exhibit significant and potential side effects. Thus, Notch inhibitors may be best used in combination with other agents or therapy. Herein, we describe …
As such, Notch inhibitors are attractive therapeutic agents, although as for other anticancer agents, they exhibit significant …
HDAC inhibitors: a new radiosensitizer for non-small-cell lung cancer.
Zhu L, Wu K, Ma S, Zhang S. Zhu L, et al. Tumori. 2015 May-Jun;101(3):257-62. doi: 10.5301/tj.5000347. Epub 2015 May 1. Tumori. 2015. PMID: 25953446 Review.
Histone deacetylase inhibitors (HDACis) are an emerging class of agents that target histone deacetylase and represent promising radiosensitizers that affect various biological processes, such as cell growth, apoptosis, DNA repair, and terminal differentiation. ...In …
Histone deacetylase inhibitors (HDACis) are an emerging class of agents that target histone deacetylase and represent promising ra …
Engineering ferroptosis radiosensitizer for SPARC-targeted degradation: A strategy to reverse radioresistant non-small cell lung cancer.
Aishajiang R, Liang Y, Du P, Zhuo X, Liu S, Wei Y, Wang T, Lei P, Yu D, Zhang H. Aishajiang R, et al. Biomaterials. 2026 Mar;326:123675. doi: 10.1016/j.biomaterials.2025.123675. Epub 2025 Sep 2. Biomaterials. 2026. PMID: 40914022
Our approach utilized engineered radiosensitizers to facilitate enhanced X-ray energy deposition, which significantly amplified radiation-induced lipid peroxidation while specifically targeting and degrading SPARC proteins. ...By promoting ferroptosis and reestablis …
Our approach utilized engineered radiosensitizers to facilitate enhanced X-ray energy deposition, which significantly amplified ra …
Patient-Derived Organoids as a Platform to Decipher and Overcome Radioresistance: From the Tumor Microenvironment to Radiosensitizer Discovery.
Yin D, Hong X, Wang X, Ding W, Wang C, Qian J, Zhou Y, Sun C, Wu Z. Yin D, et al. Curr Oncol. 2025 Dec 1;32(12):680. doi: 10.3390/curroncol32120680. Curr Oncol. 2025. PMID: 41440207 Free PMC article. Review.
Patient-derived organoids (PDOs) preserve patient genotypes and 3D architecture, offering a useful platform to investigate mechanisms of radioresistance and test radiosensitizers. We outline an end-to-end workflow-model establishment, multi-omics profiling, pharmacologic s …
Patient-derived organoids (PDOs) preserve patient genotypes and 3D architecture, offering a useful platform to investigate mechanisms of rad …
Dihydroouabain, a novel radiosensitizer for cervical cancer identified by automated high-throughput screening.
Li Z, Tamari K, Seo Y, Minami K, Takahashi Y, Tatekawa S, Otani K, Suzuki O, Isohashi F, Ogawa K. Li Z, et al. Radiother Oncol. 2020 Jul;148:21-29. doi: 10.1016/j.radonc.2020.03.047. Epub 2020 Apr 8. Radiother Oncol. 2020. PMID: 32311597
The radiosensitizing effects of candidate compounds from the LOPAC1280 chemical library were evaluated in radiosensitive and radioresistant cervical cancer cells using a clonogenic survival assay, with cell cycle analyses, and western blot analyses performed for bot …
The radiosensitizing effects of candidate compounds from the LOPAC1280 chemical library were evaluated in radiosensitive and r …
HSA-templated synergistic platform boosts radiotherapy via enhanced radiosensitization and ferroptosis induction.
Fan X, Liu J, Xie S, Tan H, Mi Z, Zhang P, Ma X, Liang Q, Yang M, Ming Y, Rong P. Fan X, et al. Drug Resist Updat. 2025 Nov;83:101293. doi: 10.1016/j.drup.2025.101293. Epub 2025 Aug 18. Drug Resist Updat. 2025. PMID: 40882450 Free article.
In vitro and in vivo studies demonstrated significantly improved tumor suppression, radiosensitivity, and immune activation compared with radiotherapy alone. Comprehensive biosafety evaluations indicated minimal systemic toxicity. ...
In vitro and in vivo studies demonstrated significantly improved tumor suppression, radiosensitivity, and immune activation compared …
BET bromodomain inhibition potentiates radiosensitivity in models of H3K27-altered diffuse midline glioma.
Watanabe J, Clutter MR, Gullette MJ, Sasaki T, Uchida E, Kaur S, Mo Y, Abe K, Ishi Y, Takata N, Natsumeda M, Gadd S, Zhang Z, Becher OJ, Hashizume R. Watanabe J, et al. J Clin Invest. 2024 May 21;134(13):e174794. doi: 10.1172/JCI174794. J Clin Invest. 2024. PMID: 38771655 Free PMC article.
Several clinical trials have attempted to enhance radiation antitumor activity using radiosensitizing agents, although none have been successful. Given this, there is a critical need for identifying effective therapeutics to enhance radiation sensitivi …
Several clinical trials have attempted to enhance radiation antitumor activity using radiosensitizing agents, although …
Repositioning disulfiram as a radiosensitizer against atypical teratoid/rhabdoid tumor.
Lee YE, Choi SA, Kwack PA, Kim HJ, Kim IH, Wang KC, Phi JH, Lee JY, Chong S, Park SH, Park KD, Hwang DW, Joo KM, Kim SK. Lee YE, et al. Neuro Oncol. 2017 Aug 1;19(8):1079-1087. doi: 10.1093/neuonc/now300. Neuro Oncol. 2017. PMID: 28340172 Free PMC article.
Although cancer stem cells of AT/RT express aldehyde dehydrogenase (ALDH), effective chemotherapies against AT/RT have not been established. Here, we examined radiosensitizing effects of disulfiram (DSF), an irreversible inhibitor of ALDH against AT/RT for a novel therapeu …
Although cancer stem cells of AT/RT express aldehyde dehydrogenase (ALDH), effective chemotherapies against AT/RT have not been established. …
CRISPR Screen Identifies HDAC3 as a Novel Radiosensitizing Target in Small Cell Lung Cancer.
Patel UA, Shi MY, Kazan JM, Nixon KCJ, Ran X, Nair SN, Huang O, Song L, Aparnathi MK, He MY, Bakhtiari M, Krishnan R, Hessenow RK, Philip V, Ketela T, Jendrossek V, Hakem R, He HH, Kridel R, Lok BH. Patel UA, et al. Mol Cancer Ther. 2026 Jan 2;25(1):183-195. doi: 10.1158/1535-7163.MCT-24-0861. Mol Cancer Ther. 2026. PMID: 40899441 Free PMC article.
Radiotherapy offers some survival benefit for selected patients with SCLC but could be enhanced with radiosensitizers. In this study, we identify HDAC3 as a novel radiosensitizing target in SCLC using a CRISPR knockout screen and demonstrate its efficacy and mechani …
Radiotherapy offers some survival benefit for selected patients with SCLC but could be enhanced with radiosensitizers. In this study, …
Inhibition of ribonucleotide reductase subunit M2 enhances the radiosensitivity of metastatic pancreatic neuroendocrine tumor.
Chow Z, Johnson J, Chauhan A, Jeong JC, Castle JT, Izumi T, Weiss H, Townsend CM Jr, Schrader J, Anthony L, Yang ES, Evers BM, Rychahou P. Chow Z, et al. Cancer Lett. 2024 Aug 1;596:216993. doi: 10.1016/j.canlet.2024.216993. Epub 2024 May 25. Cancer Lett. 2024. PMID: 38801884 Free PMC article.
Ribonucleotide Reductase (RNR) is a rate-limiting enzyme in the production of deoxyribonucleoside triphosphates (dNTPs), which are essential substrates for DNA repair after radiation damage. We explored the radiosensitization property of RNR and investigated a selec …
Ribonucleotide Reductase (RNR) is a rate-limiting enzyme in the production of deoxyribonucleoside triphosphates (dNTPs), which are essential …
245,148 results
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