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GRB7 dependent proliferation of basal-like, HER-2 positive human breast cancer cell lines is mediated in part by HER-1 signaling.
Luoh SW, Wagoner W, Wang X, Hu Z, Lai X, Chin K, Sears R, Ramsey E. Luoh SW, et al. Mol Carcinog. 2019 May;58(5):699-707. doi: 10.1002/mc.22963. Epub 2019 Jan 28. Mol Carcinog. 2019. PMID: 30604896 Free PMC article.
GRB7 gene encodes a multi-domain signal transduction molecule and is part of the core of the HER-2 amplicon. GRB7 is commonly co-amplified and overexpressed with HER-2 in human breast cancer. ...
GRB7 gene encodes a multi-domain signal transduction molecule and is part of the core of the HER-2 amplicon. GRB7 is commonly
GRB7 protein over-expression and clinical outcome in breast cancer.
Ramsey B, Bai T, Hanlon Newell A, Troxell M, Park B, Olson S, Keenan E, Luoh SW. Ramsey B, et al. Breast Cancer Res Treat. 2011 Jun;127(3):659-69. doi: 10.1007/s10549-010-1010-0. Epub 2010 Jul 16. Breast Cancer Res Treat. 2011. PMID: 20635137
The growth factor receptor-bound protein-7 gene (GRB7) encodes a multi-domain signal transduction molecule. The purpose of this study was to examine the clinical significance of GRB7 protein expression in human breast cancer. ...GRB7 protein over-expression i …
The growth factor receptor-bound protein-7 gene (GRB7) encodes a multi-domain signal transduction molecule. The purpose of this study …
HER-2 gene amplification in human breast cancer without concurrent HER-2 over-expression.
Luoh SW, Ramsey B, Hanlon Newell A, Troxell M, Hu Z, Chin K, Spellman P, Olson S, Keenan E. Luoh SW, et al. Springerplus. 2013 Aug 15;2:386. doi: 10.1186/2193-1801-2-386. eCollection 2013. Springerplus. 2013. PMID: 24102037 Free PMC article.
METHODS: HER-2 and GRB7 protein expression from 613 frozen breast tumors was determined by Western analysis. ...Four of the 7 tumors showed elevated GRB7 but not HER-2 mRNA over-expression. The breast cancer cell line HCC3153 did not over-express HER-2 protein but s …
METHODS: HER-2 and GRB7 protein expression from 613 frozen breast tumors was determined by Western analysis. ...Four of the 7 tumors …