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14,957 results

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Page 1
Randomization in clinical studies.
Lim CY, In J. Lim CY, et al. Korean J Anesthesiol. 2019 Jun;72(3):221-232. doi: 10.4097/kja.19049. Epub 2019 Apr 1. Korean J Anesthesiol. 2019. PMID: 30929415 Free PMC article. Review.
Randomized controlled trial is widely accepted as the best design for evaluating the efficacy of a new treatment because of the advantages of randomization (random allocation). ...Despite its importance, randomization has not been properl …
Randomized controlled trial is widely accepted as the best design for evaluating the efficacy of a new treatment because of th …
Blocked randomization with randomly selected block sizes.
Efird J. Efird J. Int J Environ Res Public Health. 2011 Jan;8(1):15-20. doi: 10.3390/ijerph8010015. Epub 2010 Dec 23. Int J Environ Res Public Health. 2011. PMID: 21318011 Free PMC article.
Selection and accidental bias may occur when participants are not assigned to study groups with equal probability. A simple random allocation scheme is a process by which each participant has equal likelihood of being assigned to treatment versus referent groups. .. …
Selection and accidental bias may occur when participants are not assigned to study groups with equal probability. A simple random …
Replacing permuted block design with big stick design in stratified randomization.
Cai HW, Zhou X. Cai HW, et al. Contemp Clin Trials. 2021 Jul;106:106450. doi: 10.1016/j.cct.2021.106450. Epub 2021 May 21. Contemp Clin Trials. 2021. PMID: 34029730
The PBD (Permuted Block Design) is the most widely used randomization method in clinical trials due to its comparatively simplicity. However, greater selection bias may appear, especially in open-labeled trials, because the PBD requires absolute balance at th …
The PBD (Permuted Block Design) is the most widely used randomization method in clinical trials due to its comparativel …
Randomized block experimental designs can increase the power and reproducibility of laboratory animal experiments.
Festing MF. Festing MF. ILAR J. 2014;55(3):472-6. doi: 10.1093/ilar/ilu045. ILAR J. 2014. PMID: 25541548 Review.
Randomized block experimental designs have been widely used in agricultural and industrial research for many decades. Usually they are more powerful, have higher external validity, are less subject to bias, and produce more reproducible results than the compl …
Randomized block experimental designs have been widely used in agricultural and industrial research for many decades. U …
Assessing the quality of randomization methods in randomized control trials.
Lai D, Wang D, McGillivray M, Baajour S, Raja AS, He S. Lai D, et al. Healthc (Amst). 2021 Dec;9(4):100570. doi: 10.1016/j.hjdsi.2021.100570. Epub 2021 Jul 31. Healthc (Amst). 2021. PMID: 34343852 Review.
IMPORTANCE: The randomization process is considered among the most important components of a randomized control trial (RCTs) and a core advantage of RCTs. ...Of this subset that defined protocols, the Permuted-Block Design was used most often (85.9 %). …
IMPORTANCE: The randomization process is considered among the most important components of a randomized control trial (RCTs) a …
Injectiondesign: web service of plate design with optimized stratified block randomization for modern GC/LC-MS-based sample preparation.
Lu M, Jiang H, Wang R, An S, Wang J, Yu C. Lu M, et al. BMC Bioinformatics. 2023 Dec 20;24(1):489. doi: 10.1186/s12859-023-05598-1. BMC Bioinformatics. 2023. PMID: 38124029 Free PMC article.
RESULTS: Here we describe InjectionDesign, a free online plate design service focused on GC/LC-MS-based multi-omics experiment design. It offers the ability to separate the position design from the sequence design, making the output more compatible wit …
RESULTS: Here we describe InjectionDesign, a free online plate design service focused on GC/LC-MS-based multi-omics experiment des …
A practical response adaptive block randomization (RABR) design with analytic type I error protection.
Zhan T, Cui L, Geng Z, Zhang L, Gu Y, Chan ISF. Zhan T, et al. Stat Med. 2021 Oct 15;40(23):4947-4960. doi: 10.1002/sim.9104. Epub 2021 Jun 10. Stat Med. 2021. PMID: 34111902 Clinical Trial.
Response adaptive randomization (RAR) is appealing from methodological, ethical, and pragmatic perspectives in the sense that subjects are more likely to be randomized to better performing treatment groups based on accumulating data. However, applications of RAR in …
Response adaptive randomization (RAR) is appealing from methodological, ethical, and pragmatic perspectives in the sense that subject …
How to randomize.
Vickers AJ. Vickers AJ. J Soc Integr Oncol. 2006 Fall;4(4):194-8. doi: 10.2310/7200.2006.023. J Soc Integr Oncol. 2006. PMID: 17022927 Free PMC article. Review.
The purpose of randomization is to prevent selection bias: randomization procedures must therefore ensure that researchers are unable to predict the group to which a patient will be randomized until the patient is unambiguously registered on study; moreover, …
The purpose of randomization is to prevent selection bias: randomization procedures must therefore ensure that researchers are …
Design of a group-randomized Streptococcus pneumoniae vaccine trial.
Moulton LH, O'Brien KL, Kohberger R, Chang I, Reid R, Weatherholtz R, Hackell JG, Siber GR, Santosham M. Moulton LH, et al. Control Clin Trials. 2001 Aug;22(4):438-52. doi: 10.1016/s0197-2456(01)00132-5. Control Clin Trials. 2001. PMID: 11514043 Clinical Trial.
Thirty-eight geographically and socially distinct areas were randomized within blocks formed by population size and geographic location. This design affords the opportunity to capture the effects of herd immunity (indirect effects) by estimating the impact of …
Thirty-eight geographically and socially distinct areas were randomized within blocks formed by population size and geographic …
Minimization in randomized clinical trials.
Coart E, Bamps P, Quinaux E, Sturbois G, Saad ED, Burzykowski T, Buyse M. Coart E, et al. Stat Med. 2023 Dec 10;42(28):5285-5311. doi: 10.1002/sim.9916. Epub 2023 Oct 23. Stat Med. 2023. PMID: 37867447
Completely random allocation ensures comparability between the treatment groups for all known and unknown prognostic factors. ...In this Tutorial, the performance of minimization, a popular covariate-adaptive procedure, is compared with two other commonly used proce …
Completely random allocation ensures comparability between the treatment groups for all known and unknown prognostic factors. …
14,957 results
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