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Year Number of Results
1975 2
1977 1
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1983 2
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1989 4
1990 10
1991 84
1992 83
1993 145
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1995 177
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1998 258
1999 235
2000 295
2001 408
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2003 643
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2005 1190
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2007 1670
2008 1856
2009 2102
2010 2383
2011 2717
2012 3023
2013 3463
2014 3583
2015 3815
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2018 3917
2019 3972
2020 3996
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61,135 results

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Page 1
Effect of rapamycin on aging and age-related diseases-past and future.
Selvarani R, Mohammed S, Richardson A. Selvarani R, et al. Geroscience. 2021 Jun;43(3):1135-1158. doi: 10.1007/s11357-020-00274-1. Epub 2020 Oct 10. Geroscience. 2021. PMID: 33037985 Free PMC article. Review.
In 2009, rapamycin was reported to increase the lifespan of mice when implemented later in life. ...In this review, we focus on those areas in which there is strong evidence for rapamycin's effect on aging and age-related diseases in mice, e.g., lifespan, car …
In 2009, rapamycin was reported to increase the lifespan of mice when implemented later in life. ...In this review, we focus on those …
Targeting ageing with rapamycin and its derivatives in humans: a systematic review.
Lee DJW, Hodzic Kuerec A, Maier AB. Lee DJW, et al. Lancet Healthy Longev. 2024 Feb;5(2):e152-e162. doi: 10.1016/S2666-7568(23)00258-1. Lancet Healthy Longev. 2024. PMID: 38310895 Free article.
Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. ...
Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the e …
Evaluation of off-label rapamycin use to promote healthspan in 333 adults.
Kaeberlein TL, Green AS, Haddad G, Hudson J, Isman A, Nyquist A, Rosen BS, Suh Y, Zalzala S, Zhang X, Blagosklonny MV, An JY, Kaeberlein M. Kaeberlein TL, et al. Geroscience. 2023 Oct;45(5):2757-2768. doi: 10.1007/s11357-023-00818-1. Epub 2023 May 16. Geroscience. 2023. PMID: 37191826 Free PMC article.
Rapamycin (sirolimus) is an FDA-approved drug with immune-modulating and growth-inhibitory properties. ...Here, we describe the general characteristics of a patient cohort using off-label rapamycin and present initial evidence that rapamycin can be use …
Rapamycin (sirolimus) is an FDA-approved drug with immune-modulating and growth-inhibitory properties. ...Here, we describe th …
Rapamycin Responds to Alzheimer's Disease: A Potential Translational Therapy.
Hou SJ, Zhang SX, Li Y, Xu SY. Hou SJ, et al. Clin Interv Aging. 2023 Oct 2;18:1629-1639. doi: 10.2147/CIA.S429440. eCollection 2023. Clin Interv Aging. 2023. PMID: 37810956 Free PMC article. Review.
Although numerous studies have been conducted or are underway on AD, there are still no effective drugs to reverse the pathological features and clinical manifestations of AD. Rapamycin is a macrolide antibiotic produced by Streptomyces hygroscopicus. As a classical mechan …
Although numerous studies have been conducted or are underway on AD, there are still no effective drugs to reverse the pathological features …
Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results.
Moel M, Harinath G, Lee V, Nyquist A, Morgan SL, Isman A, Zalzala S. Moel M, et al. Aging (Albany NY). 2025 Apr 4;17(4):908-936. doi: 10.18632/aging.206235. Epub 2025 Apr 4. Aging (Albany NY). 2025. PMID: 40188830 Free PMC article. Clinical Trial.
DESIGN: This 48-week decentralized, double-blinded, randomized, placebo-controlled trial (NCT04488601) evaluated the long-term safety of intermittent low-dose rapamycin in a healthy, normative-aging human cohort. Participants received placebo, 5 mg or 10 mg compounded r …
DESIGN: This 48-week decentralized, double-blinded, randomized, placebo-controlled trial (NCT04488601) evaluated the long-term safety of int …
Rapamycin protects aging muscle.
Tang H, Shrager JB, Goldman D. Tang H, et al. Aging (Albany NY). 2019 Aug 27;11(16):5868-5870. doi: 10.18632/aging.102176. Epub 2019 Aug 27. Aging (Albany NY). 2019. PMID: 31454792 Free PMC article. No abstract available.
Why Is Rapamycin Not a Rapalog?
Kuerec AH, Maier AB. Kuerec AH, et al. Gerontology. 2023;69(6):657-659. doi: 10.1159/000528985. Epub 2023 Jan 7. Gerontology. 2023. PMID: 36617414 Free article.
Rapamycin (sirolimus) is an immunosuppressive drug approved by the Food and Drug Administration (FDA). ...The analogs of rapamycin are referred to as "rapalogs." Rapamycin is the parent compound and should therewith not be called a "rapalog."...
Rapamycin (sirolimus) is an immunosuppressive drug approved by the Food and Drug Administration (FDA). ...The analogs of ra …
Rapamycin for aging stem cells.
Hambright WS, Philippon MJ, Huard J. Hambright WS, et al. Aging (Albany NY). 2020 Aug 4;12(15):15184-15185. doi: 10.18632/aging.103816. Epub 2020 Aug 4. Aging (Albany NY). 2020. PMID: 32756013 Free PMC article. No abstract available.
Fasting and rapamycin: diabetes versus benevolent glucose intolerance.
Blagosklonny MV. Blagosklonny MV. Cell Death Dis. 2019 Aug 13;10(8):607. doi: 10.1038/s41419-019-1822-8. Cell Death Dis. 2019. PMID: 31406105 Free PMC article. Review.
Rapamycin (Sirolimus) slows aging, extends life span, and prevents age-related diseases, including diabetic complications such as retinopathy. Puzzlingly, rapamycin can induce insulin sensitivity, but may also induce insulin resistance or glucose intolerance …
Rapamycin (Sirolimus) slows aging, extends life span, and prevents age-related diseases, including diabetic complications such …
[Rapamycin and CCI-779].
Alexandre J, Raymond E, Armand JP. Alexandre J, et al. Bull Cancer. 1999 Oct;86(10):808-11. Bull Cancer. 1999. PMID: 10572230 Free article. Review. French.
Rapamycin (sirolimus) is a macrolide, related to cyclosporine with immunosuppressive properties and antiproliferative activity in various human tumor cells lines and tumor xenograft models. The cytosolic kinase mTOR which controls the initiation of the translation o …
Rapamycin (sirolimus) is a macrolide, related to cyclosporine with immunosuppressive properties and antiproliferative activity …
61,135 results
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