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Acarbose improved survival for Apc(+/Min) mice.
Dodds SG, Parihar M, Javors M, Nie J, Musi N, Dave Sharp Z, Hasty P. Dodds SG, et al. Aging Cell. 2020 Feb;19(2):e13088. doi: 10.1111/acel.13088. Epub 2020 Jan 6. Aging Cell. 2020. PMID: 31903726 Free PMC article.
Acarbose blocks the digestion of complex carbohydrates, and the NIA Intervention Testing Program (ITP) found that it improved survival when fed to mice. Yet, we do not know if lifespan extension was caused by its effect on metabolism with regard to the soma or cance …
Acarbose blocks the digestion of complex carbohydrates, and the NIA Intervention Testing Program (ITP) found that it improved surviva …
Extending lifespan by modulating the growth hormone/insulin-like growth factor-1 axis: coming of age.
Duran-Ortiz S, List EO, Basu R, Kopchick JJ. Duran-Ortiz S, et al. Pituitary. 2021 Jun;24(3):438-456. doi: 10.1007/s11102-020-01117-0. Epub 2021 Jan 18. Pituitary. 2021. PMID: 33459974 Free PMC article. Review.
Studies performed in yeast, worms, flies and mice subjected to genetic and pharmacological interventions have given insight into the cellular and molecular mechanisms associated with longevity. ...Interestingly, interventions that extend longevity in adult …
Studies performed in yeast, worms, flies and mice subjected to genetic and pharmacological interventions have given insight into the …
NIA's Intervention Testing Program at 10 years of age.
Warner HR. Warner HR. Age (Dordr). 2015;37(2):22. doi: 10.1007/s11357-015-9761-5. Epub 2015 Mar 1. Age (Dordr). 2015. PMID: 25726185 Free PMC article.
The previous 20 years of basic research on aging has identified a large number of genes and gene products whose expression can be manipulated in a variety of ways to increase the healthy life span of animal models such as yeast, nematodes, fruit flies, and mice. In an over …
The previous 20 years of basic research on aging has identified a large number of genes and gene products whose expression can be manipulate …
Translational Geroscience: From invertebrate models to companion animal and human interventions.
Lee MB, Kaeberlein M. Lee MB, et al. Transl Med Aging. 2018 Jan;2:15-29. doi: 10.1016/j.tma.2018.08.002. Epub 2018 Aug 17. Transl Med Aging. 2018. PMID: 32368707 Free PMC article.
Beginning in invertebrate model systems, interventions are discovered and then characterized using other invertebrate model systems (evolutionary translation), models of genetic diversity, and disease models. Vertebrate model systems, particularly mice, can then be utilize …
Beginning in invertebrate model systems, interventions are discovered and then characterized using other invertebrate model systems (evoluti …
Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an alpha-glucosidase inhibitor or a Nrf2-inducer.
Strong R, Miller RA, Antebi A, Astle CM, Bogue M, Denzel MS, Fernandez E, Flurkey K, Hamilton KL, Lamming DW, Javors MA, de Magalhães JP, Martinez PA, McCord JM, Miller BF, Müller M, Nelson JF, Ndukum J, Rainger GE, Richardson A, Sabatini DM, Salmon AB, Simpkins JW, Steegenga WT, Nadon NL, Harrison DE. Strong R, et al. Aging Cell. 2016 Oct;15(5):872-84. doi: 10.1111/acel.12496. Epub 2016 Jun 16. Aging Cell. 2016. PMID: 27312235 Free PMC article.
The National Institute on Aging Interventions Testing Program (ITP) evaluates agents hypothesized to increase healthy lifespan in genetically heterogeneous mice. ...These results underscore the reproducibility of ITP longevity studies and illustrate th …
The National Institute on Aging Interventions Testing Program (ITP) evaluates agents hypothesized to increase healthy lifespan in gen …
Lifespan benefits for the combination of rapamycin plus acarbose and for captopril in genetically heterogeneous mice.
Strong R, Miller RA, Cheng CJ, Nelson JF, Gelfond J, Allani SK, Diaz V, Dorigatti AO, Dorigatti J, Fernandez E, Galecki A, Ginsburg B, Hamilton KL, Javors MA, Kornfeld K, Kaeberlein M, Kumar S, Lombard DB, Lopez-Cruzan M, Miller BF, Rabinovitch P, Reifsnyder P, Rosenthal NA, Bogue MA, Salmon AB, Suh Y, Verdin E, Weissbach H, Newman J, Maccchiarini F, Harrison DE. Strong R, et al. Aging Cell. 2022 Dec;21(12):e13724. doi: 10.1111/acel.13724. Epub 2022 Sep 30. Aging Cell. 2022. PMID: 36179270 Free PMC article.
Mice bred in 2017 and entered into the C2017 cohort were tested for possible lifespan benefits of (R/S)-1,3-butanediol (BD), captopril (Capt), leucine (Leu), the Nrf2-activating botanical mixture PB125, sulindac, syringaresinol, or the combination of rapamycin and a …
Mice bred in 2017 and entered into the C2017 cohort were tested for possible lifespan benefits of (R/S)-1,3-butanediol (BD), captopri …
Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging.
Mau T, O'Brien M, Ghosh AK, Miller RA, Yung R. Mau T, et al. J Gerontol A Biol Sci Med Sci. 2020 Jan 1;75(1):89-98. doi: 10.1093/gerona/glz177. J Gerontol A Biol Sci Med Sci. 2020. PMID: 31353414 Free PMC article.
The National Institute on Aging (NIA)-sponsored Interventions Testing Program (ITP) has identified a number of dietary drug interventions that significantly extend life span, including rapamycin, acarbose, and 17-alpha estradiol. ...Our study focuses on the effects …
The National Institute on Aging (NIA)-sponsored Interventions Testing Program (ITP) has identified a number of dietary drug intervent …