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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2006 1
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2010 29
2011 59
2012 74
2013 104
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2,042 results

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Page 1
Acetyl-CoA Derived from Hepatic Peroxisomal beta-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation.
He A, Chen X, Tan M, Chen Y, Lu D, Zhang X, Dean JM, Razani B, Lodhi IJ. He A, et al. Mol Cell. 2020 Jul 2;79(1):30-42.e4. doi: 10.1016/j.molcel.2020.05.007. Epub 2020 May 29. Mol Cell. 2020. PMID: 32473093 Free PMC article.
Autophagy is activated by prolonged fasting but cannot overcome the ensuing hepatic lipid overload, resulting in fatty liver. ...Hepatic Acox1 deficiency markedly lowered total cytosolic acetyl-CoA levels, which led to decreased Raptor acetylation and reduced lysosomal loc …
Autophagy is activated by prolonged fasting but cannot overcome the ensuing hepatic lipid overload, resulting in fatty liver. ...Hepa …
Inhibition of lysosomal LAMTOR1 increases autophagy by suppressing the MTORC1 pathway to ameliorate lipid accumulations in MAFLD.
Jang Y, Ko M, Lee JY, Kim JY, Lee EW, Kwon HJ. Jang Y, et al. Autophagy. 2025 Dec;21(12):2633-2649. doi: 10.1080/15548627.2025.2519054. Epub 2025 Jul 6. Autophagy. 2025. PMID: 40548398 Free PMC article.
We found that binding of ACA to LAMTOR1 induces its release from the LAMTOR complex, leading to inhibition of MTOR (mechanistic target of rapamycin kinase) complex 1 (MTORC1), thereby increasing autophagy. This process helps ameliorate metabolic disorders by …
We found that binding of ACA to LAMTOR1 induces its release from the LAMTOR complex, leading to inhibition of MTOR (mechanistic target of …
MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint.
Yang H, Wen Y, Zhang M, Liu Q, Zhang H, Zhang J, Lu L, Ye T, Bai X, Xiao G, Wang M. Yang H, et al. Autophagy. 2020 Feb;16(2):271-288. doi: 10.1080/15548627.2019.1606647. Epub 2019 Apr 21. Autophagy. 2020. PMID: 31007149 Free PMC article.
Inhibition of MTORC1 by TMJ local injection of rapamycin in rats or inducible ablation of MTORC1 expression selectively in chondrocytes in mice promoted chondrocyte autophagy and suppressed apoptosis, and reduced TMJ cartilage loss induced by UAC. ...T …
Inhibition of MTORC1 by TMJ local injection of rapamycin in rats or inducible ablation of MTORC1 expression selectively …
How autophagy controls the intestinal epithelial barrier.
Foerster EG, Mukherjee T, Cabral-Fernandes L, Rocha JDB, Girardin SE, Philpott DJ. Foerster EG, et al. Autophagy. 2022 Jan;18(1):86-103. doi: 10.1080/15548627.2021.1909406. Epub 2021 Apr 27. Autophagy. 2022. PMID: 33906557 Free PMC article. Review.
Macroautophagy/autophagy is a cellular catabolic process that results in lysosome-mediated recycling of organelles and protein aggregates, as well as the destruction of intracellular pathogens. Its role in the maintenance of the intestinal epithelium is of particular inter …
Macroautophagy/autophagy is a cellular catabolic process that results in lysosome-mediated recycling of organelles and protein aggreg …
The Endo-Lysosomal Damage Response.
Meyer H, Kravic B. Meyer H, et al. Annu Rev Biochem. 2024 Aug;93(1):367-387. doi: 10.1146/annurev-biochem-030222-102505. Epub 2024 Jul 2. Annu Rev Biochem. 2024. PMID: 38594929 Free article. Review.
Lysosomes are the degradative endpoints of material delivered by endocytosis and autophagy and are therefore particularly prone to damage. Membrane permeabilization or full rupture of lysosomal or late endosomal compartments is highly deleterious because it threatens cellu …
Lysosomes are the degradative endpoints of material delivered by endocytosis and autophagy and are therefore particularly prone to da …
PP2Ac Regulates Autophagy via Mediating mTORC1 and ULK1 During Osteoclastogenesis in the Subchondral Bone of Osteoarthritis.
Zhang H, Ge G, Zhang W, Sun H, Liang X, Xia Y, Du J, Wu Z, Bai J, Yang H, Yang X, Zhou J, Xu Y, Geng D. Zhang H, et al. Adv Sci (Weinh). 2024 Sep;11(36):e2404080. doi: 10.1002/advs.202404080. Epub 2024 Jul 23. Adv Sci (Weinh). 2024. PMID: 39041921 Free PMC article.
It is found that the catalytic subunit of protein phosphatase 2A (PP2Ac) is highly expressed during osteoclastogenesis in the early stage of OA and is correlated with autophagy. Knockdown or inhibition of PP2Ac weakened autophagy during osteoclastogenesis. ...Additi …
It is found that the catalytic subunit of protein phosphatase 2A (PP2Ac) is highly expressed during osteoclastogenesis in the early stage of …
Glutamine, MTOR and autophagy: a multiconnection relationship.
Bodineau C, Tomé M, Murdoch PDS, Durán RV. Bodineau C, et al. Autophagy. 2022 Nov;18(11):2749-2750. doi: 10.1080/15548627.2022.2062875. Epub 2022 Apr 26. Autophagy. 2022. PMID: 35470752 Free PMC article.
Cancer cells metabolize glutamine mostly through glutaminolysis, a metabolic pathway that activates MTORC1. The AMPK-MTORC1 signaling axis is a key regulator of cell growth and proliferation. ...Rather, we demonstrated the crucial role of ASNS (asparagine synthetase …
Cancer cells metabolize glutamine mostly through glutaminolysis, a metabolic pathway that activates MTORC1. The AMPK-MTORC1 si …
Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease.
Panwar V, Singh A, Bhatt M, Tonk RK, Azizov S, Raza AS, Sengupta S, Kumar D, Garg M. Panwar V, et al. Signal Transduct Target Ther. 2023 Oct 2;8(1):375. doi: 10.1038/s41392-023-01608-z. Signal Transduct Target Ther. 2023. PMID: 37779156 Free PMC article. Review.
The mammalian target of rapamycin (mTOR) is a protein kinase that controls cellular metabolism, catabolism, immune responses, autophagy, survival, proliferation, and migration, to maintain cellular homeostasis. The mTOR signaling cascade consists of two distinct mul …
The mammalian target of rapamycin (mTOR) is a protein kinase that controls cellular metabolism, catabolism, immune responses, auto …
Lysosomes as coordinators of cellular catabolism, metabolic signalling and organ physiology.
Settembre C, Perera RM. Settembre C, et al. Nat Rev Mol Cell Biol. 2024 Mar;25(3):223-245. doi: 10.1038/s41580-023-00676-x. Epub 2023 Nov 24. Nat Rev Mol Cell Biol. 2024. PMID: 38001393 Review.
In this Review, we discuss recent findings on lysosome-dependent signalling pathways, focusing on how the lysosome senses nutrient availability through its physical and functional association with mechanistic target of rapamycin complex 1 …
In this Review, we discuss recent findings on lysosome-dependent signalling pathways, focusing on how the lysosome senses nutrient availabil …
Autophagy preserves hematopoietic stem cells by restraining MTORC1-mediated cellular anabolism.
Borsa M, Obba S, Richter FC, Zhang H, Riffelmacher T, Carrelha J, Alsaleh G, Jacobsen SEW, Simon AK. Borsa M, et al. Autophagy. 2024 Jan;20(1):45-57. doi: 10.1080/15548627.2023.2247310. Epub 2023 Aug 23. Autophagy. 2024. PMID: 37614038 Free PMC article.
Here we address why autophagy depletion leads to a drastic loss of the stem cell compartment. Using inducible deletion of autophagy specifically in adult hematopoietic stem cells (HSCs) and in mice chimeric for autophagy-deficient and normal HSCs, we demonstr …
Here we address why autophagy depletion leads to a drastic loss of the stem cell compartment. Using inducible deletion of autophag …
2,042 results