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Recent advances in calorie restriction research on aging.
Chung KW, Kim DH, Park MH, Choi YJ, Kim ND, Lee J, Yu BP, Chung HY. Chung KW, et al. Exp Gerontol. 2013 Oct;48(10):1049-53. doi: 10.1016/j.exger.2012.11.007. Epub 2012 Nov 29. Exp Gerontol. 2013. PMID: 23201549 Review.
The extension of both median and maximum lifespan and the suppression of age-related diseases in laboratory animals by reduced food intake, i.e., calorie restriction (CR) are regarded as hallmarks of CR's anti-aging action. The diverse efficacy of CR to counteract aging ef …
The extension of both median and maximum lifespan and the suppression of age-related diseases in laboratory animals by reduced food intake, …
Adaptive Physiological and Morphological Adjustments Mediated by Intestinal Stem Cells in Response to Food Availability in Mice.
Peña-Villalobos I, Casanova-Maldonado I, Lois P, Sabat P, Palma V. Peña-Villalobos I, et al. Front Physiol. 2019 Jan 8;9:1821. doi: 10.3389/fphys.2018.01821. eCollection 2018. Front Physiol. 2019. PMID: 30670976 Free PMC article.
Several studies have evaluated plastic changes in the morphology of the digestive tract in rodents subjected to caloric restriction or restricted availability. Nevertheless, studies that link these morphological responses to physiological consequences are scarce. .. …
Several studies have evaluated plastic changes in the morphology of the digestive tract in rodents subjected to caloric restrictio …
A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging.
McCormick MA, Delaney JR, Tsuchiya M, Tsuchiyama S, Shemorry A, Sim S, Chou AC, Ahmed U, Carr D, Murakami CJ, Schleit J, Sutphin GL, Wasko BM, Bennett CF, Wang AM, Olsen B, Beyer RP, Bammler TK, Prunkard D, Johnson SC, Pennypacker JK, An E, Anies A, Castanza AS, Choi E, Dang N, Enerio S, Fletcher M, Fox L, Goswami S, Higgins SA, Holmberg MA, Hu D, Hui J, Jelic M, Jeong KS, Johnston E, Kerr EO, Kim J, Kim D, Kirkland K, Klum S, Kotireddy S, Liao E, Lim M, Lin MS, Lo WC, Lockshon D, Miller HA, Moller RM, Muller B, Oakes J, Pak DN, Peng ZJ, Pham KM, Pollard TG, Pradeep P, Pruett D, Rai D, Robison B, Rodriguez AA, Ros B, Sage M, Singh MK, Smith ED, Snead K, Solanky A, Spector BL, Steffen KK, Tchao BN, Ting MK, Vander Wende H, Wang D, Welton KL, Westman EA, Brem RB, Liu XG, Suh Y, Zhou Z, Kaeberlein M, Kennedy BK. McCormick MA, et al. Cell Metab. 2015 Nov 3;22(5):895-906. doi: 10.1016/j.cmet.2015.09.008. Epub 2015 Oct 8. Cell Metab. 2015. PMID: 26456335 Free PMC article.
Multiple functional gene clusters were identified, and full genome-to-genome comparison demonstrated a significant conservation in longevity pathways between yeast and C. elegans. Among the mechanisms of aging identified, deletion of tRNA exporter LOS1 robustly extended li …
Multiple functional gene clusters were identified, and full genome-to-genome comparison demonstrated a significant conservation in lo …
Comparison between Tibetan and Small-tailed Han sheep in adipocyte phenotype, lipid metabolism and energy homoeostasis regulation of adipose tissues when consuming diets of different energy levels.
Jing X, Zhou J, Degen A, Wang W, Guo Y, Kang J, Liu P, Ding L, Shang Z, Qiu Q, Ding X, Long R. Jing X, et al. Br J Nutr. 2020 Oct 14;124(7):668-680. doi: 10.1017/S0007114520001701. Epub 2020 May 14. Br J Nutr. 2020. PMID: 32406340
Moreover, Tibetan sheep had lower AMPKalpha mRNA expression but higher mammalian target of rapamycin mRNA expression in the adipocytes than Small-tailed Han sheep. We concluded that Tibetan sheep had lower catabolism but higher anabolism in adipose tissue and reduced the c …
Moreover, Tibetan sheep had lower AMPKalpha mRNA expression but higher mammalian target of rapamycin mRNA expression in the adipocyte …
Metabolomic and Lipidomic Signature of Skeletal Muscle with Constitutively Active Mechanistic Target of Rapamycin Complex 1.
Maroto R, Graber TG, Romsdahl TB, Kudlicki A, Russell WK, Rasmussen BB. Maroto R, et al. J Nutr. 2023 Dec;153(12):3397-3405. doi: 10.1016/j.tjnut.2023.10.016. Epub 2023 Oct 28. J Nutr. 2023. PMID: 37898335 Free PMC article.
BACKGROUND: Regulation of mechanistic target of rapamycin complex 1 (mTORC1) plays an important role in aging and nutrition. For example, caloric restriction reduces mTORC1 signaling and extends lifespan, whereas nutrient abundance and obesity increase mTORC1 …
BACKGROUND: Regulation of mechanistic target of rapamycin complex 1 (mTORC1) plays an important role in aging and nutrition. For exam …