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mTOR inhibition improves immune function in the elderly.
Mannick JB, Del Giudice G, Lattanzi M, Valiante NM, Praestgaard J, Huang B, Lonetto MA, Maecker HT, Kovarik J, Carson S, Glass DJ, Klickstein LB. Mannick JB, et al. Sci Transl Med. 2014 Dec 24;6(268):268ra179. doi: 10.1126/scitranslmed.3009892. Sci Transl Med. 2014. PMID: 25540326 Clinical Trial.
Inhibition of the mammalian target of rapamycin (mTOR) pathway extends life span in all species studied to date, and in mice delays the onset of age-related diseases and comorbidities. However, it is unknown if mTOR inhibition affects aging or its consequences in hu …
Inhibition of the mammalian target of rapamycin (mTOR) pathway extends life span in all species studied to date, and in mice delays t …
Therapeutic mTOR blockade in systemic autoimmunity: Implications for antiviral immunity and extension of lifespan.
Geier C, Perl A. Geier C, et al. Autoimmun Rev. 2021 Dec;20(12):102984. doi: 10.1016/j.autrev.2021.102984. Epub 2021 Oct 27. Autoimmun Rev. 2021. PMID: 34718162 Free PMC article. Review.
The mechanistic target of rapamycin (mTOR) pathway integrates metabolic cues into cell fate decisions. A particularly fateful event during the adaptive immune response is the engagement of a T cell receptor by its cognate antigen presented by an antigen-presenting c …
The mechanistic target of rapamycin (mTOR) pathway integrates metabolic cues into cell fate decisions. A particularly fateful event d …
TORC1 inhibition enhances immune function and reduces infections in the elderly.
Mannick JB, Morris M, Hockey HP, Roma G, Beibel M, Kulmatycki K, Watkins M, Shavlakadze T, Zhou W, Quinn D, Glass DJ, Klickstein LB. Mannick JB, et al. Sci Transl Med. 2018 Jul 11;10(449):eaaq1564. doi: 10.1126/scitranslmed.aaq1564. Sci Transl Med. 2018. PMID: 29997249 Clinical Trial.
Inhibition of the mechanistic target of rapamycin (mTOR) protein kinase extends life span and ameliorates aging-related pathologies including declining immune function in model organisms. ...In addition, we observed an up-regulation of antiviral gene expressi …
Inhibition of the mechanistic target of rapamycin (mTOR) protein kinase extends life span and ameliorates aging-related pathol …
Effects of Graded Levels of Calorie Restriction XXI: Impact of Short-term Graded Restriction on Gene Expression Profiles of Stomach and Skeletal Muscle.
Xia F, Wu Y, Li M, Mitchell SE, Speakman JR. Xia F, et al. J Gerontol A Biol Sci Med Sci. 2025 Jun 10;80(7):glae299. doi: 10.1093/gerona/glae299. J Gerontol A Biol Sci Med Sci. 2025. PMID: 39715339 Free article.
Transcriptomic analysis showed the numbers of differentially expressed genes relative to 12 h ad libitum (12AL) feeding increased as the level of restriction increased. We found the canonical CR and aging related pathways, eukaryotic translation initiation factor 2 (EIF2) …
Transcriptomic analysis showed the numbers of differentially expressed genes relative to 12 h ad libitum (12AL) feeding increased as the lev …
mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells.
Chen C, Liu Y, Liu Y, Zheng P. Chen C, et al. Sci Signal. 2009 Nov 24;2(98):ra75. doi: 10.1126/scisignal.2000559. Sci Signal. 2009. PMID: 19934433 Free PMC article.
Age-related declines in hematopoietic stem cell (HSC) function may contribute to anemia, poor response to vaccination, and tumorigenesis. Here, we show that mammalian target of rapamycin (mTOR) activity is increased in HSCs from old mice compared to those from young …
Age-related declines in hematopoietic stem cell (HSC) function may contribute to anemia, poor response to vaccination, and tumorigene …
Estradiol enhances influenza vaccine responses through B cell metabolic reprogramming in female mice.
St Clair LA, Watters EG, Yin A, Liu JA, Chaulagain S, Thompson EA, Klein SL. St Clair LA, et al. mBio. 2026 Apr 8;17(4):e0396525. doi: 10.1128/mbio.03965-25. Epub 2026 Feb 26. mBio. 2026. PMID: 41744685 Free PMC article.
These data identify estrogen signaling as a regulator of B cell metabolism that supports greater expansion and function of antibody-secreting cells following vaccination in females compared with males. IMPORTANCE: Vaccine-induced immunity differs between the sexes, …
These data identify estrogen signaling as a regulator of B cell metabolism that supports greater expansion and function of antibody-secretin …
The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells.
Marçais A, Cherfils-Vicini J, Viant C, Degouve S, Viel S, Fenis A, Rabilloud J, Mayol K, Tavares A, Bienvenu J, Gangloff YG, Gilson E, Vivier E, Walzer T. Marçais A, et al. Nat Immunol. 2014 Aug;15(8):749-757. doi: 10.1038/ni.2936. Epub 2014 Jun 29. Nat Immunol. 2014. PMID: 24973821 Free PMC article.
This process was essential for sustaining NK cell proliferation during development and the acquisition of cytolytic potential during inflammation or viral infection. The mTORC1 inhibitor rapamycin inhibited NK cell cytotoxicity both in mice and humans; this probably contri …
This process was essential for sustaining NK cell proliferation during development and the acquisition of cytolytic potential during inflamm …
Targeting the biology of ageing with mTOR inhibitors to improve immune function in older adults: phase 2b and phase 3 randomised trials.
Mannick JB, Teo G, Bernardo P, Quinn D, Russell K, Klickstein L, Marshall W, Shergill S. Mannick JB, et al. Lancet Healthy Longev. 2021 May;2(5):e250-e262. doi: 10.1016/S2666-7568(21)00062-3. Epub 2021 May 6. Lancet Healthy Longev. 2021. PMID: 33977284 Free PMC article. Clinical Trial.
BACKGROUND: The COVID-19 pandemic highlights the need for therapies that improve immune function in older adults, including interferon (IFN)-induced antiviral immunity that declines with age. ...FUNDING: resTORbio and the National Institute on Aging....
BACKGROUND: The COVID-19 pandemic highlights the need for therapies that improve immune function in older adults, including interfero …