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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2002 1
2003 1
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2005 2
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2008 4
2009 12
2010 21
2011 18
2012 29
2013 43
2014 55
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654 results

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Page 1
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.
Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, Nadon NL, Wilkinson JE, Frenkel K, Carter CS, Pahor M, Javors MA, Fernandez E, Miller RA. Harrison DE, et al. Nature. 2009 Jul 16;460(7253):392-5. doi: 10.1038/nature08221. Epub 2009 Jul 8. Nature. 2009. PMID: 19587680 Free PMC article.
Here we report that rapamycin, an inhibitor of the mTOR pathway, extends median and maximal lifespan of both male and female mice when fed beginning at 600 days of age. ...Rapamycin may extend lifespan by postponing death from cancer, by retardi …
Here we report that rapamycin, an inhibitor of the mTOR pathway, extends median and maximal lifespan of both male and f …
mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review.
Weichhart T. Weichhart T. Gerontology. 2018;64(2):127-134. doi: 10.1159/000484629. Epub 2017 Dec 1. Gerontology. 2018. PMID: 29190625 Free PMC article. Review.
A growing list of evidence suggests that mTOR signaling influences longevity and aging. Inhibition of the mTOR complex 1 (mTORC1) with rapamycin is currently the only known pharmacological treatment that increases lifespan in all model organisms …
A growing list of evidence suggests that mTOR signaling influences longevity and aging. Inhibition of the mTOR complex …
Targeting the biology of aging with mTOR inhibitors.
Mannick JB, Lamming DW. Mannick JB, et al. Nat Aging. 2023 Jun;3(6):642-660. doi: 10.1038/s43587-023-00416-y. Epub 2023 May 4. Nat Aging. 2023. PMID: 37142830 Free PMC article. Review.
Inhibition of the protein kinase mechanistic target of rapamycin (mTOR) with the Food and Drug Administration (FDA)-approved therapeutic rapamycin promotes health and longevity in diverse model organisms. More recently, specific inhibition of mTORC1 to …
Inhibition of the protein kinase mechanistic target of rapamycin (mTOR) with the Food and Drug Administration (FDA)-approved t …
Lysosomes signal through the epigenome to regulate longevity across generations.
Zhang Q, Dang W, Wang MC. Zhang Q, et al. Science. 2025 Sep 25;389(6767):1353-1360. doi: 10.1126/science.adn8754. Epub 2025 Sep 25. Science. 2025. PMID: 40997170 Free PMC article.
Lysosomes act as a signaling hub to sense metabolic cues and regulate longevity. We found that lysosomal metabolic pathways signal through the epigenome to regulate transgenerational longevity in Caenorhabditis elegans. Activation of lysosomal lipid signaling and ly …
Lysosomes act as a signaling hub to sense metabolic cues and regulate longevity. We found that lysosomal metabolic pathways signal th …
Ergothioneine and its prospects as an anti-ageing compound.
Apparoo Y, Phan CW, Kuppusamy UR, Sabaratnam V. Apparoo Y, et al. Exp Gerontol. 2022 Dec;170:111982. doi: 10.1016/j.exger.2022.111982. Epub 2022 Oct 14. Exp Gerontol. 2022. PMID: 36244584 Free article. Review.
Healthy ageing is a crucial process that needs to be highlighted as it affects the quality of lifespan. An increase in oxidative stress along with ageing is the major factor related to the age-associated diseases, especially neurodegenerative disorders. ...This review aims …
Healthy ageing is a crucial process that needs to be highlighted as it affects the quality of lifespan. An increase in oxidative stre …
Metformin: Is it a drug for all reasons and diseases?
Triggle CR, Mohammed I, Bshesh K, Marei I, Ye K, Ding H, MacDonald R, Hollenberg MD, Hill MA. Triggle CR, et al. Metabolism. 2022 Aug;133:155223. doi: 10.1016/j.metabol.2022.155223. Epub 2022 May 29. Metabolism. 2022. PMID: 35640743 Free article. Review.
Clinical trials, including MILES (Metformin In Longevity Study), and TAME (Targeting Aging with Metformin), have been designed to determine if metformin can offset aging and extend lifespan. ...It remains unclear as to whether all of these putative beneficial effect …
Clinical trials, including MILES (Metformin In Longevity Study), and TAME (Targeting Aging with Metformin), have been designed to det …
Targeting ageing with rapamycin and its derivatives in humans: a systematic review.
Lee DJW, Hodzic Kuerec A, Maier AB. Lee DJW, et al. Lancet Healthy Longev. 2024 Feb;5(2):e152-e162. doi: 10.1016/S2666-7568(23)00258-1. Lancet Healthy Longev. 2024. PMID: 38310895 Free article.
Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. ...
Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summaris …
Rapamycin for longevity: the pros, the cons, and future perspectives.
Roark KM, Iffland PH 2nd. Roark KM, et al. Front Aging. 2025 Jun 20;6:1628187. doi: 10.3389/fragi.2025.1628187. eCollection 2025. Front Aging. 2025. PMID: 40620657 Free PMC article. Review.
Therefore physicians and "biohackers" are using mTOR inhibition via rapamycin (and rapamycin analogs) off-label for prevention of age-related conditions despite not being widely recognized as a treatment by the broader clinical community. ...We aim to summari …
Therefore physicians and "biohackers" are using mTOR inhibition via rapamycin (and rapamycin analogs) off-label for pre …
Paracrine FGF21 dynamically modulates mTOR signaling to regulate thymus function across the lifespan.
Wedemeyer SA, Jones NE, Raza IGA, Green FM, Xiao Y, Semwal MK, Garza AK, Archuleta KS, Wimberly KL, Venables T, Holländer GA, Griffith AV. Wedemeyer SA, et al. Nat Aging. 2025 Apr;5(4):588-606. doi: 10.1038/s43587-024-00801-1. Epub 2025 Feb 19. Nat Aging. 2025. PMID: 39972173 Free PMC article.
Cortical thymic epithelial cells (cTECs) are primary targets of thymic aging, and recent studies suggested that their maintenance requires mTOR signaling downstream of medullary TEC (mTEC)-derived growth factors. Here, to test this hypothesis, we generated a knock-in mouse …
Cortical thymic epithelial cells (cTECs) are primary targets of thymic aging, and recent studies suggested that their maintenance requires …
Geroscience: A Translational Review.
Kritchevsky SB, Cummings SR. Kritchevsky SB, et al. JAMA. 2025 Sep 23;334(12):1094-1102. doi: 10.1001/jama.2025.11289. JAMA. 2025. PMID: 40773213 Review.
In adults with obesity and diabetes, compared with non-caloric restriction intervention groups, randomization to receive caloric restriction was associated with a 15% reduction in all-cause mortality and a lower incidence of weight-related chronic diseases. Rapamycin, a dr …
In adults with obesity and diabetes, compared with non-caloric restriction intervention groups, randomization to receive caloric restriction …
654 results