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Rapidly growing Brtl/+ mouse model of osteogenesis imperfecta improves bone mass and strength with sclerostin antibody treatment.
Sinder BP, Salemi JD, Ominsky MS, Caird MS, Marini JC, Kozloff KM. Sinder BP, et al. Bone. 2015 Feb;71:115-23. doi: 10.1016/j.bone.2014.10.012. Epub 2014 Oct 23. Bone. 2015. PMID: 25445450 Free PMC article.
To explore the effect of Scl-Ab on the rapidly growing OI skeleton, we treated rapidly growing 3week old Brtl/+ mice, harboring a typical heterozygous OI-causing GlyCys substitution on col1a1, for 5weeks with Scl-Ab. ...While Scl-Ab was anabolic …
To explore the effect of Scl-Ab on the rapidly growing OI skeleton, we treated rapidly growing 3week old Brtl …
Effect of anti-sclerostin therapy and osteogenesis imperfecta on tissue-level properties in growing and adult mice while controlling for tissue age.
Sinder BP, Lloyd WR, Salemi JD, Marini JC, Caird MS, Morris MD, Kozloff KM. Sinder BP, et al. Bone. 2016 Mar;84:222-229. doi: 10.1016/j.bone.2016.01.001. Epub 2016 Jan 6. Bone. 2016. PMID: 26769006 Free PMC article.
The purpose of this study was to investigate the role of Scl-Ab on bone quality by determining bone material composition and tissue-level mechanical properties in normal wild type (WT) tissue, as well as mice with a typical OI GlyCys mutation (Brtl/+) in type I collagen. …
The purpose of this study was to investigate the role of Scl-Ab on bone quality by determining bone material composition and tissue-level me …
Single dose of bisphosphonate preserves gains in bone mass following cessation of sclerostin antibody in Brtl/+ osteogenesis imperfecta model.
Perosky JE, Khoury BM, Jenks TN, Ward FS, Cortright K, Meyer B, Barton DK, Sinder BP, Marini JC, Caird MS, Kozloff KM. Perosky JE, et al. Bone. 2016 Dec;93:79-85. doi: 10.1016/j.bone.2016.09.013. Epub 2016 Sep 15. Bone. 2016. PMID: 27641475 Free PMC article.
To determine whether cessation of sclerostin antibody therapy in a growing OI skeleton requires sequential anti-resorptive treatment to preserve anabolic gains in bone mass, we treated 3week old Brtl/+ and wild type mice for 5weeks with SclAb, and then withdrew trea …
To determine whether cessation of sclerostin antibody therapy in a growing OI skeleton requires sequential anti-resorptive treatment …