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Year Number of Results
1941 1
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1956 1
1961 1
1962 1
1963 2
1964 1
1965 10
1966 19
1967 10
1968 12
1969 22
1970 21
1971 23
1972 34
1973 38
1974 29
1975 135
1976 148
1977 117
1978 113
1979 109
1980 145
1981 167
1982 172
1983 195
1984 220
1985 225
1986 290
1987 300
1988 269
1989 282
1990 308
1991 376
1992 368
1993 428
1994 445
1995 466
1996 528
1997 528
1998 552
1999 562
2000 671
2001 645
2002 655
2003 685
2004 681
2005 730
2006 722
2007 769
2008 731
2009 801
2010 834
2011 888
2012 881
2013 826
2014 833
2015 824
2016 794
2017 811
2018 856
2019 885
2020 887
2021 913
2022 986
2023 919
2024 911
2025 874
2026 3

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26,514 results

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Page 1
Glycolysis Rate-Limiting Enzymes: Novel Potential Regulators of Rheumatoid Arthritis Pathogenesis.
Zuo J, Tang J, Lu M, Zhou Z, Li Y, Tian H, Liu E, Gao B, Liu T, Shao P. Zuo J, et al. Front Immunol. 2021 Nov 24;12:779787. doi: 10.3389/fimmu.2021.779787. eCollection 2021. Front Immunol. 2021. PMID: 34899740 Free PMC article. Review.
The specific pathogenesis of RA, a chronic inflammatory disease, remains unclear. However, both key glycolysis rate-limiting enzymes, hexokinase-II (HK-II), phosphofructokinase-1 (PFK-1), and pyruvate kinase M2 (PKM2), as well as indirect rate-limit …
The specific pathogenesis of RA, a chronic inflammatory disease, remains unclear. However, both key glycolysis rate-limiting …
Temperature, Dynamics, and Enzyme-Catalyzed Reaction Rates.
Arcus VL, Mulholland AJ. Arcus VL, et al. Annu Rev Biophys. 2020 May 6;49:163-180. doi: 10.1146/annurev-biophys-121219-081520. Epub 2020 Feb 4. Annu Rev Biophys. 2020. PMID: 32040931 Review.
We review the adaptations of enzyme activity to different temperatures. Psychrophilic (cold-adapted) enzymes show significantly different activation parameters (lower activation enthalpies and entropies) from their mesophilic counterparts. ...This is explained by ma …
We review the adaptations of enzyme activity to different temperatures. Psychrophilic (cold-adapted) enzymes show significantl …
Steroidogenic enzymes.
Miller WL. Miller WL. Endocr Dev. 2008;13:1-18. doi: 10.1159/000134751. Endocr Dev. 2008. PMID: 18493130 Review.
The enzymes and pathways of steroidogenesis are familiar to most endocrinologists, but the biochemistry and molecular biology of these processes are still being studied. ...Chronic regulation is principally at the level of transcription of the gene for P450 side chain clea …
The enzymes and pathways of steroidogenesis are familiar to most endocrinologists, but the biochemistry and molecular biology of thes …
The role of OXCT1 in the pathogenesis of cancer as a rate-limiting enzyme of ketone body metabolism.
Zhang S, Xie C. Zhang S, et al. Life Sci. 2017 Aug 15;183:110-115. doi: 10.1016/j.lfs.2017.07.003. Epub 2017 Jul 4. Life Sci. 2017. PMID: 28684065 Review.
Cancer cells are well documented to reprogram their metabolism in order to support the maintenance and reproduction. 3-oxoacid CoA-transferase 1 (OXCT1) is a key enzyme in ketone body metabolism that catalyzes the first and rate-determining step of ketolysis. …
Cancer cells are well documented to reprogram their metabolism in order to support the maintenance and reproduction. 3-oxoacid CoA-transfera …
Superefficient enzymes.
Stroppolo ME, Falconi M, Caccuri AM, Desideri A. Stroppolo ME, et al. Cell Mol Life Sci. 2001 Sep;58(10):1451-60. doi: 10.1007/PL00000788. Cell Mol Life Sci. 2001. PMID: 11693526 Free PMC article. Review.
Such enzymes are considered to be perfect, since their rate-limiting step is not due to any chemical event but to the diffusional association rate between the enzyme and the substrate. Often the enzyme-substrate encounter is facilitated either t …
Such enzymes are considered to be perfect, since their rate-limiting step is not due to any chemical event but to the d …
Violaxanthin de-epoxidase is rate-limiting for non-photochemical quenching under subsaturating light or during chilling in Arabidopsis.
Chen Z, Gallie DR. Chen Z, et al. Plant Physiol Biochem. 2012 Sep;58:66-82. doi: 10.1016/j.plaphy.2012.06.010. Epub 2012 Jun 17. Plant Physiol Biochem. 2012. PMID: 22771437
In this work, we overexpressed or repressed the expression of VDE in Arabidopsis (Arabidopsis thaliana) to examine whether VDE is rate-limiting for the induction of NPQ. Increasing VDE expression increased the de-epoxidation state of xanthophyll pigments, the rate o …
In this work, we overexpressed or repressed the expression of VDE in Arabidopsis (Arabidopsis thaliana) to examine whether VDE is rate …
Down-regulation of aminolevulinate synthase, the rate-limiting enzyme for heme biosynthesis in Alzheimer's disease.
Dwyer BE, Smith MA, Richardson SL, Perry G, Zhu X. Dwyer BE, et al. Neurosci Lett. 2009 Aug 28;460(2):180-4. doi: 10.1016/j.neulet.2009.05.058. Epub 2009 May 27. Neurosci Lett. 2009. PMID: 19477221 Free PMC article.
To begin testing this hypothesis, we used qRT-PCR to quantify the expression of aminolevulinate synthase (ALAS1) and porphobilinogen deaminase (PBGD), rate-limiting enzymes in the heme biosynthesis pathway. The relative expression of ALAS1 mRNA, the first and …
To begin testing this hypothesis, we used qRT-PCR to quantify the expression of aminolevulinate synthase (ALAS1) and porphobilinogen deamina …
Elusive control.
Westerhoff HV, Kholodenko BN, Cascante M, Van Dam K. Westerhoff HV, et al. J Bioenerg Biomembr. 1995 Oct;27(5):491-7. doi: 10.1007/BF02110189. J Bioenerg Biomembr. 1995. PMID: 8718454 Review.
The concept of a single rate-limiting step was proven to be too simplistic for understanding control and regulation of metabolism. ...It turns out that this elusiveness of control has itself led to increased understanding of the roles played in metabolic control and …
The concept of a single rate-limiting step was proven to be too simplistic for understanding control and regulation of metabol …
Cryoenzymology.
Fink AL, Cartwright SJ. Fink AL, et al. CRC Crit Rev Biochem. 1981;11(2):145-207. CRC Crit Rev Biochem. 1981. PMID: 6273065 Review.
The major advantage lies in the ability to accumulate and stabilize productive enzyme-substrate intermediates for sufficient lengths of time to allow the collection of high resolution structural data, e.g. by X-ray diffraction. In addition, intermediates which are not dete …
The major advantage lies in the ability to accumulate and stabilize productive enzyme-substrate intermediates for sufficient lengths …
Enzyme dynamics from NMR spectroscopy.
Palmer AG 3rd. Palmer AG 3rd. Acc Chem Res. 2015 Feb 17;48(2):457-65. doi: 10.1021/ar500340a. Epub 2015 Jan 9. Acc Chem Res. 2015. PMID: 25574774 Free PMC article. Review.
This Account reviews NMR spin relaxation studies of the enzymes ribonuclease HI from mesophilic (Escherichia coli) and thermophilic (Thermus thermophilus) bacteria, E. coli AlkB, and Saccharomyces cerevisiae triosephosphate isomerase to illustrate the contributions of conf …
This Account reviews NMR spin relaxation studies of the enzymes ribonuclease HI from mesophilic (Escherichia coli) and thermophilic ( …
26,514 results
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