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Year Number of Results
1941 1
1949 1
1955 1
1956 1
1961 1
1962 1
1963 2
1964 1
1965 10
1966 19
1967 10
1968 12
1969 22
1970 21
1971 23
1972 34
1973 38
1974 29
1975 135
1976 148
1977 117
1978 113
1979 109
1980 145
1981 167
1982 172
1983 195
1984 220
1985 225
1986 290
1987 300
1988 269
1989 282
1990 308
1991 376
1992 368
1993 428
1994 445
1995 466
1996 528
1997 528
1998 552
1999 562
2000 671
2001 645
2002 655
2003 685
2004 681
2005 730
2006 722
2007 769
2008 731
2009 801
2010 834
2011 888
2012 881
2013 826
2014 833
2015 824
2016 794
2017 811
2018 856
2019 885
2020 887
2021 913
2022 986
2023 919
2024 911
2025 972
2026 25

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26,613 results

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Page 1
Glycolysis Rate-Limiting Enzymes: Novel Potential Regulators of Rheumatoid Arthritis Pathogenesis.
Zuo J, Tang J, Lu M, Zhou Z, Li Y, Tian H, Liu E, Gao B, Liu T, Shao P. Zuo J, et al. Front Immunol. 2021 Nov 24;12:779787. doi: 10.3389/fimmu.2021.779787. eCollection 2021. Front Immunol. 2021. PMID: 34899740 Free PMC article. Review.
The specific pathogenesis of RA, a chronic inflammatory disease, remains unclear. However, both key glycolysis rate-limiting enzymes, hexokinase-II (HK-II), phosphofructokinase-1 (PFK-1), and pyruvate kinase M2 (PKM2), as well as indirect rate-limit …
The specific pathogenesis of RA, a chronic inflammatory disease, remains unclear. However, both key glycolysis rate-limiting …
Steroidogenic enzymes.
Miller WL. Miller WL. Endocr Dev. 2008;13:1-18. doi: 10.1159/000134751. Endocr Dev. 2008. PMID: 18493130 Review.
The enzymes and pathways of steroidogenesis are familiar to most endocrinologists, but the biochemistry and molecular biology of these processes are still being studied. ...Chronic regulation is principally at the level of transcription of the gene for P450 side chain clea …
The enzymes and pathways of steroidogenesis are familiar to most endocrinologists, but the biochemistry and molecular biology of thes …
PI3K drives the de novo synthesis of coenzyme A from vitamin B5.
Dibble CC, Barritt SA, Perry GE, Lien EC, Geck RC, DuBois-Coyne SE, Bartee D, Zengeya TT, Cohen EB, Yuan M, Hopkins BD, Meier JL, Clohessy JG, Asara JM, Cantley LC, Toker A. Dibble CC, et al. Nature. 2022 Aug;608(7921):192-198. doi: 10.1038/s41586-022-04984-8. Epub 2022 Jul 27. Nature. 2022. PMID: 35896750 Free PMC article.
Although PANK2 is known to catalyse the rate-determining first step of CoA synthesis, we find that the minimally characterized but highly conserved PANK4(9) is a rate-limiting suppressor of CoA synthesis through its metabolite phosphatase activity. ...
Although PANK2 is known to catalyse the rate-determining first step of CoA synthesis, we find that the minimally characterized …
Rate-Determining and Rate-Limiting Steps in the Clearance and Excretion of a Potent and Selective p21-Activated Kinase Inhibitor: A Case Study of Rapid Hepatic Uptake and Slow Elimination in Rat.
Fan PW, Chen JZ, Allan Jaochico M, La H, Liu N, Mulder T, Cass RT, Durk M, Messick K, Valle N, Liu S, Lee W, Crawford JJ, Rudolf J, Murray LJ, Cyrus Khojasteh S, Wright M. Fan PW, et al. Drug Metab Lett. 2016;10(2):91-100. doi: 10.2174/1872312810666160411144358. Drug Metab Lett. 2016. PMID: 27063863 Free PMC article.
BACKGROUND: Significant under-prediction of in vivo clearance in rat was observed for a potent p21-activated kinase (PAK1) inhibitor, GNE1. OBJECTIVE: Rate-determining (rapid uptake) and rate-limiting (slow excretion) steps in systemic clearance and el …
BACKGROUND: Significant under-prediction of in vivo clearance in rat was observed for a potent p21-activated kinase (PAK1) inhibitor, GNE1. …
The role of OXCT1 in the pathogenesis of cancer as a rate-limiting enzyme of ketone body metabolism.
Zhang S, Xie C. Zhang S, et al. Life Sci. 2017 Aug 15;183:110-115. doi: 10.1016/j.lfs.2017.07.003. Epub 2017 Jul 4. Life Sci. 2017. PMID: 28684065 Review.
Cancer cells are well documented to reprogram their metabolism in order to support the maintenance and reproduction. 3-oxoacid CoA-transferase 1 (OXCT1) is a key enzyme in ketone body metabolism that catalyzes the first and rate-determining step of ketolysis. …
Cancer cells are well documented to reprogram their metabolism in order to support the maintenance and reproduction. 3-oxoacid CoA-transfera …
Violaxanthin de-epoxidase is rate-limiting for non-photochemical quenching under subsaturating light or during chilling in Arabidopsis.
Chen Z, Gallie DR. Chen Z, et al. Plant Physiol Biochem. 2012 Sep;58:66-82. doi: 10.1016/j.plaphy.2012.06.010. Epub 2012 Jun 17. Plant Physiol Biochem. 2012. PMID: 22771437
In this work, we overexpressed or repressed the expression of VDE in Arabidopsis (Arabidopsis thaliana) to examine whether VDE is rate-limiting for the induction of NPQ. Increasing VDE expression increased the de-epoxidation state of xanthophyll pigments, the rate o …
In this work, we overexpressed or repressed the expression of VDE in Arabidopsis (Arabidopsis thaliana) to examine whether VDE is rate …
Down-regulation of aminolevulinate synthase, the rate-limiting enzyme for heme biosynthesis in Alzheimer's disease.
Dwyer BE, Smith MA, Richardson SL, Perry G, Zhu X. Dwyer BE, et al. Neurosci Lett. 2009 Aug 28;460(2):180-4. doi: 10.1016/j.neulet.2009.05.058. Epub 2009 May 27. Neurosci Lett. 2009. PMID: 19477221 Free PMC article.
To begin testing this hypothesis, we used qRT-PCR to quantify the expression of aminolevulinate synthase (ALAS1) and porphobilinogen deaminase (PBGD), rate-limiting enzymes in the heme biosynthesis pathway. The relative expression of ALAS1 mRNA, the first and …
To begin testing this hypothesis, we used qRT-PCR to quantify the expression of aminolevulinate synthase (ALAS1) and porphobilinogen deamina …
Role of mitochondria in steroidogenesis.
Papadopoulos V, Miller WL. Papadopoulos V, et al. Best Pract Res Clin Endocrinol Metab. 2012 Dec;26(6):771-90. doi: 10.1016/j.beem.2012.05.002. Epub 2012 Jun 16. Best Pract Res Clin Endocrinol Metab. 2012. PMID: 23168279 Review.
Adrenal gonadal, placental and brain mitochondria contain several steroidogenic enzymes, notably the cholesterol side chain cleavage enzyme, P450scc, which is the enzymatic rate-limiting step in steroidogenesis which determines cellular steroidogenic c …
Adrenal gonadal, placental and brain mitochondria contain several steroidogenic enzymes, notably the cholesterol side chain cleavage …
The Moderately Efficient Enzyme: Futile Encounters and Enzyme Floppiness.
Bar-Even A, Milo R, Noor E, Tawfik DS. Bar-Even A, et al. Biochemistry. 2015 Aug 18;54(32):4969-77. doi: 10.1021/acs.biochem.5b00621. Epub 2015 Aug 6. Biochemistry. 2015. PMID: 26219075 Review.
Thus, the perfect enzyme's catalytic efficiency, kcat/KM, is constrained by only the diffusion on-rate, and the fraction of futile encounters (defined as phi) approaches zero. ...Thus, the "fast equilibrium" assumption holds for the vast majority of enzymes. …
Thus, the perfect enzyme's catalytic efficiency, kcat/KM, is constrained by only the diffusion on-rate, and the fraction of fu …
Involvement of the alpha-subunit N-terminus in the mechanism of the Na+,K+-ATPase.
Lev B, Chennath M, Cranfield CG, Cornelius F, Allen TW, Clarke RJ. Lev B, et al. Biochim Biophys Acta Mol Cell Res. 2023 Oct;1870(7):119539. doi: 10.1016/j.bbamcr.2023.119539. Epub 2023 Jul 20. Biochim Biophys Acta Mol Cell Res. 2023. PMID: 37479188 Free article. Review.
Previous studies have shown that cytoplasmic K(+) release and the associated E2 E1 conformational change of the Na(+),K(+)-ATPase is a major rate-determining step of the enzyme's ion pumping cycle and hence a prime site of acute regulatory intervention …
Previous studies have shown that cytoplasmic K(+) release and the associated E2 E1 conformational change of the Na(+),K(+)-ATPase is a major …
26,613 results
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