Lenvatinib plus pembrolizumab versus lenvatinib plus placebo for advanced hepatocellular carcinoma (LEAP-002): a randomised, double-blind, phase 3 trial.
Llovet JM, Kudo M, Merle P, Meyer T, Qin S, Ikeda M, Xu R, Edeline J, Ryoo BY, Ren Z, Masi G, Kwiatkowski M, Lim HY, Kim JH, Breder V, Kumada H, Cheng AL, Galle PR, Kaneko S, Wang A, Mody K, Dutcus C, Dubrovsky L, Siegel AB, Finn RS; LEAP-002 Investigators.
Llovet JM, et al.
Lancet Oncol. 2023 Dec;24(12):1399-1410. doi: 10.1016/S1470-2045(23)00469-2.
Lancet Oncol. 2023.
PMID: 38039993
Clinical Trial.
Median overall survival was 21.2 months (95% CI 19.0-23.6; 252 [64%] of 395 died) with lenvatinib plus pembrolizumab versus 19.0 months (17.2-21.7; 282 [71%] of 399 died) with lenvatinib plus placebo (hazard ratio [HR] 0.84; 95% CI 0.71-1.00; stratified log-rank p=0.023). …
Median overall survival was 21.2 months (95% CI 19.0-23.6; 252 [64%] of 395 died) with lenvatinib plus pembrolizumab versus 19.0 months (17. …