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Year Number of Results
1935 1
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1945 7
1946 1
1947 5
1948 6
1949 12
1950 7
1951 7
1952 3
1953 11
1954 63
1955 236
1956 446
1957 431
1958 349
1959 275
1960 265
1961 249
1962 308
1963 466
1964 613
1965 464
1966 469
1967 615
1968 593
1969 643
1970 553
1971 573
1972 553
1973 589
1974 590
1975 541
1976 464
1977 421
1978 368
1979 418
1980 376
1981 398
1982 476
1983 541
1984 661
1985 714
1986 660
1987 655
1988 649
1989 612
1990 564
1991 567
1992 524
1993 502
1994 388
1995 368
1996 326
1997 314
1998 280
1999 290
2000 269
2001 240
2002 243
2003 224
2004 218
2005 220
2006 193
2007 218
2008 183
2009 187
2010 164
2011 194
2012 203
2013 206
2014 183
2015 193
2016 154
2017 138
2018 130
2019 137
2020 136
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2024 107

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Page 1
A literature perspective on the pharmacological applications of yohimbine.
Jabir NR, Firoz CK, Zughaibi TA, Alsaadi MA, Abuzenadah AM, Al-Asmari AI, Alsaieedi A, Ahmed BA, Ramu AK, Tabrez S. Jabir NR, et al. Ann Med. 2022 Dec;54(1):2861-2875. doi: 10.1080/07853890.2022.2131330. Ann Med. 2022. PMID: 36263866 Free PMC article. Review.
The pharmacological activity of yohimbine is mediated by the combined action of the central and peripheral nervous systems. It selectively blocks the pre and postsynaptic alpha(2)-adrenergic receptors and has a moderate affinity for alpha1 and alpha2 subtypes. Yohimbine …
The pharmacological activity of yohimbine is mediated by the combined action of the central and peripheral nervous systems. It select …
Yohimbine.
Shannon M, Neuman MI. Shannon M, et al. Pediatr Emerg Care. 2000 Feb;16(1):49-50. doi: 10.1097/00006565-200002000-00015. Pediatr Emerg Care. 2000. PMID: 10698146 Review. No abstract available.
Pharmacological action of rauwolscine.
KOHLI JD, DE NN. KOHLI JD, et al. Nature. 1956 Jun 23;177(4521):1182. doi: 10.1038/1771182a0. Nature. 1956. PMID: 13334509 No abstract available.
[3H]Rauwolscine: an antagonist radioligand for the cloned human 5-hydroxytryptamine2b (5-HT2B) receptor.
Wainscott DB, Sasso DA, Kursar JD, Baez M, Lucaites VL, Nelson DL. Wainscott DB, et al. Naunyn Schmiedebergs Arch Pharmacol. 1998 Jan;357(1):17-24. doi: 10.1007/pl00005133. Naunyn Schmiedebergs Arch Pharmacol. 1998. PMID: 9459568
When [3H]rauwolscine was initially tested for its usefulness as a radioligand, complex competition curves were obtained. ...In addition, many of the compounds with antagonist structures displayed higher affinity for the 5-HT2B receptor when [3H]rauwolscine was the r …
When [3H]rauwolscine was initially tested for its usefulness as a radioligand, complex competition curves were obtained. ...In additi …
Yeast Platforms for Production and Screening of Bioactive Derivatives of Rauwolscine.
Bradley SA, Hansson FG, Lehka BJ, Rago D, Pinho P, Peng H, Adhikari KB, Haidar AK, Hansen LG, Volkova D, Holtz M, Muyo Abad S, Ma X, Koudounas K, Besseau S, Gautron N, Mélin C, Marc J, Birer Williams C, Courdavault V, Jensen ED, Keasling JD, Zhang J, Jensen MK. Bradley SA, et al. ACS Synth Biol. 2024 May 17;13(5):1498-1512. doi: 10.1021/acssynbio.4c00039. Epub 2024 Apr 18. ACS Synth Biol. 2024. PMID: 38635307
Here, we report yeast-based cell factories capable of de novo production of corynanthe-type MIAs rauwolscine, yohimbine, tetrahydroalstonine, and corynanthine. From this, we demonstrate regioselective biosynthesis of 4 fluorinated derivatives of these compounds and …
Here, we report yeast-based cell factories capable of de novo production of corynanthe-type MIAs rauwolscine, yohimbine, tetra …
Different pharmacological properties of two equipotent antagonists (clozapine and rauwolscine) for 5-HT2B receptors in rat stomach fundus.
Villazón M, Enguix MJ, Tristán H, Honrubia MA, Brea J, Maayani S, Cadavid MI, Loza MI. Villazón M, et al. Biochem Pharmacol. 2003 Sep 15;66(6):927-37. doi: 10.1016/s0006-2952(03)00426-x. Biochem Pharmacol. 2003. PMID: 12963479
On the basis of the previously demonstrated constitutive activity in natural systems and the possibility of specific ligand-induced conformations, the aims of this study were: (i) to characterize the effects of two competitive antagonists (rauwolscine, RAU and clozapine, C …
On the basis of the previously demonstrated constitutive activity in natural systems and the possibility of specific ligand-induced conforma …
[3H]rauwolscine (alpha-yohimbine): a specific antagonist radioligand for brain alpha 2-adrenergic receptors.
Perry BD, U'Prichard DC. Perry BD, et al. Eur J Pharmacol. 1981 Dec 17;76(4):461-4. doi: 10.1016/0014-2999(81)90123-0. Eur J Pharmacol. 1981. PMID: 6276200
[3H]Rauwolscine, a specific and potent alpha 2-antagonist radioligand, was used to characterize alpha 2-receptor binding in bovine cerebral cortex. [3H]Rauwolscine binding was reversible, stereospecific, and saturable. Association, dissociation, and saturation studi …
[3H]Rauwolscine, a specific and potent alpha 2-antagonist radioligand, was used to characterize alpha 2-receptor binding in bovine ce …
[3H]-rauwolscine binding to alpha 2-adrenoceptors in the mammalian kidney: apparent receptor heterogeneity between species.
Neylon CB, Summers RJ. Neylon CB, et al. Br J Pharmacol. 1985 Jun;85(2):349-59. doi: 10.1111/j.1476-5381.1985.tb08868.x. Br J Pharmacol. 1985. PMID: 2862942 Free PMC article.
Binding of the alpha 2-adrenoceptor antagonist [3H]-rauwolscine was characterized in membrane preparations from the kidneys of mouse, rat, rabbit, dog, and man. ...Saturation studies showed that the affinity of [3H]-rauwolscine was similar in all species (2.33-3.03 …
Binding of the alpha 2-adrenoceptor antagonist [3H]-rauwolscine was characterized in membrane preparations from the kidneys of mouse, …
[3H]rauwolscine labels alpha 2-adrenoceptors and 5-HT1A receptors in human cerebral cortex.
Convents A, De Keyser J, De Backer JP, Vauquelin G. Convents A, et al. Eur J Pharmacol. 1989 Jan 17;159(3):307-10. doi: 10.1016/0014-2999(89)90163-5. Eur J Pharmacol. 1989. PMID: 2537740
[3H]Rauwolscine binds with high affinity to alpha 2-adrenoceptors (Kd = 4.8 +/- 1.3 nM, Bmax = 79 +/- 26 fmol/mg protein, micromolar affinity for 5-HT) as well as to 5-HT1-like receptors (Kd = 13 +/- 2.7 nM, Bmax = 147 +/- 11.4 fmol/mg protein, nanomolar affinity for 5-HT) …
[3H]Rauwolscine binds with high affinity to alpha 2-adrenoceptors (Kd = 4.8 +/- 1.3 nM, Bmax = 79 +/- 26 fmol/mg protein, micromolar …
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