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1959 1
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1975 24
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1988 167
1989 215
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2007 1050
2008 1144
2009 1136
2010 1256
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2013 1683
2014 1773
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43,448 results

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Page 1
The benefits of clustering in TNF receptor superfamily signaling.
Vanamee ÉS, Faustman DL. Vanamee ÉS, et al. Front Immunol. 2023 Aug 17;14:1225704. doi: 10.3389/fimmu.2023.1225704. eCollection 2023. Front Immunol. 2023. PMID: 37662920 Free PMC article. Review.
The tumor necrosis factor (TNF) receptor superfamily is a structurally and functionally related group of cell surface receptors that play crucial roles in various cellular processes, including apoptosis, cell survival, and immune regulation. This review paper synthe …
The tumor necrosis factor (TNF) receptor superfamily is a structurally and functionally related group of cell surface receptors …
Ligand-independent receptor clustering modulates transmembrane signaling: a new paradigm.
Sánchez MF, Tampé R. Sánchez MF, et al. Trends Biochem Sci. 2023 Feb;48(2):156-171. doi: 10.1016/j.tibs.2022.08.002. Epub 2022 Sep 14. Trends Biochem Sci. 2023. PMID: 36115755 Review.
Cell-surface receptors mediate communication between cells and their environment. Lateral membrane organization and dynamic receptor cluster formation are fundamental in signal transduction and cell signaling. However, it is not yet fully understood how re …
Cell-surface receptors mediate communication between cells and their environment. Lateral membrane organization and dynamic recept …
Innate immune receptor clustering and its role in immune regulation.
Li M, Yu Y. Li M, et al. J Cell Sci. 2021 Feb 17;134(4):jcs249318. doi: 10.1242/jcs.249318. J Cell Sci. 2021. PMID: 33597156 Free PMC article. Review.
The discovery of receptor clustering in the activation of adaptive immune cells has revolutionized our understanding of the physical basis of immune signal transduction. ...Here, we highlight these pioneering efforts and the outstanding questions that remain to be a …
The discovery of receptor clustering in the activation of adaptive immune cells has revolutionized our understanding of the ph …
Analyzing the Mycobacterium tuberculosis immune response by T-cell receptor clustering with GLIPH2 and genome-wide antigen screening.
Huang H, Wang C, Rubelt F, Scriba TJ, Davis MM. Huang H, et al. Nat Biotechnol. 2020 Oct;38(10):1194-1202. doi: 10.1038/s41587-020-0505-4. Epub 2020 Apr 27. Nat Biotechnol. 2020. PMID: 32341563 Free PMC article.
CD4(+) T cells are critical to fighting pathogens, but a comprehensive analysis of human T-cell specificities is hindered by the diversity of HLA alleles (>20,000) and the complexity of many pathogen genomes. We previously described GLIPH, an algorithm to cluster …
CD4(+) T cells are critical to fighting pathogens, but a comprehensive analysis of human T-cell specificities is hindered by the dive …
Clustering and Annotation of T Cell Receptor Repertoires.
Valkiers S, Gielis S, Van Deuren VML, Laukens K, Meysman P. Valkiers S, et al. Methods Mol Biol. 2023;2673:33-51. doi: 10.1007/978-1-0716-3239-0_3. Methods Mol Biol. 2023. PMID: 37258905
Immunological protection against a wide variety of pathogens is largely mediated by the diverse and dynamic T cell receptor (TCR) repertoire, a crucial component of the adaptive immune system. An encounter with infectious agents stimulates specific T cells to initiate a di …
Immunological protection against a wide variety of pathogens is largely mediated by the diverse and dynamic T cell receptor (TCR) rep …
Clustering of Death Receptor for Apoptosis Using Nanoscale Patterns of Peptides.
Wang Y, Baars I, Fördös F, Högberg B. Wang Y, et al. ACS Nano. 2021 Jun 22;15(6):9614-9626. doi: 10.1021/acsnano.0c10104. Epub 2021 May 21. ACS Nano. 2021. PMID: 34019379 Free PMC article.
The nanoscale spatial organization of transmembrane tumor necrosis factor (TNF) receptors has been implicated in the regulation of cellular fate. Accordingly, molecular tools that can induce specific arrangements of these receptors on cell surfaces would give us an …
The nanoscale spatial organization of transmembrane tumor necrosis factor (TNF) receptors has been implicated in the regulation of ce …
Quantifiable predictive features define epitope-specific T cell receptor repertoires.
Dash P, Fiore-Gartland AJ, Hertz T, Wang GC, Sharma S, Souquette A, Crawford JC, Clemens EB, Nguyen THO, Kedzierska K, La Gruta NL, Bradley P, Thomas PG. Dash P, et al. Nature. 2017 Jul 6;547(7661):89-93. doi: 10.1038/nature22383. Epub 2017 Jun 21. Nature. 2017. PMID: 28636592 Free PMC article.
T cells are defined by a heterodimeric surface receptor, the T cell receptor (TCR), that mediates recognition of pathogen-associated epitopes through interactions with peptide and major histocompatibility complexes (pMHCs). ...Our analyses demonstrate that each epit …
T cells are defined by a heterodimeric surface receptor, the T cell receptor (TCR), that mediates recognition of pathogen-asso …
Clustering of the zeta-Chain Can Initiate T Cell Receptor Signaling.
Ma Y, Lim YJ, Benda A, Lou J, Goyette J, Gaus K. Ma Y, et al. Int J Mol Sci. 2020 May 15;21(10):3498. doi: 10.3390/ijms21103498. Int J Mol Sci. 2020. PMID: 32429097 Free PMC article.
In reconstituted COS-7 cells, only Lck expression was required to initiate zeta-chain phosphorylation upon zeta-chain clustering, which leads to the recruitment of tandem SH2 domain of Zap70 from cell cytosol to the newly formed zeta-chain clusters at the plasma mem …
In reconstituted COS-7 cells, only Lck expression was required to initiate zeta-chain phosphorylation upon zeta-chain clustering, whi …
Clustering models.
Schamel WW, Reth M. Schamel WW, et al. Adv Exp Med Biol. 2008;640:64-73. doi: 10.1007/978-0-387-09789-3_6. Adv Exp Med Biol. 2008. PMID: 19065784 Review.
Models proposed for MIRR triggering can be grouped into three categories. Firstly, ligand binding invokes receptor clustering, resulting in the approximation of kinases to the MIRR and receptor phosphorylation. Secondly, ligand binding induces a conformationa …
Models proposed for MIRR triggering can be grouped into three categories. Firstly, ligand binding invokes receptor clustering, …
Chimeric antigen receptor clustering via cysteines enhances T-cell efficacy against tumor.
Wang Y, Gao Y, Niu C, Wang B, Zhao S, Roex G, Qian J, Qie J, Chen L, Yi C, Anguille S, Liu J, Luo F, Chu Y. Wang Y, et al. Cancer Immunol Immunother. 2022 Nov;71(11):2801-2814. doi: 10.1007/s00262-022-03195-4. Epub 2022 Apr 19. Cancer Immunol Immunother. 2022. PMID: 35441325 Free PMC article.
The cysteines in the hinge were found to facilitate CAR(Cys) clustering upon antigen stimulation and promote the antitumor activity of CAR-T cells. Compared with most conventionally used CAR-T cells with CD8alpha-derived hinge (CAR(conv)-T cells), CAR(Cys)-T cells exhibite …
The cysteines in the hinge were found to facilitate CAR(Cys) clustering upon antigen stimulation and promote the antitumor activity o …
43,448 results
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