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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 1
1946 1
1947 2
1948 1
1950 1
1951 2
1952 3
1955 1
1956 3
1957 2
1958 5
1959 2
1960 2
1961 2
1962 3
1963 20
1964 25
1965 18
1966 21
1967 42
1968 65
1969 60
1970 68
1971 101
1972 119
1973 122
1974 118
1975 144
1976 160
1977 151
1978 191
1979 200
1980 262
1981 309
1982 424
1983 463
1984 536
1985 697
1986 784
1987 956
1988 1205
1989 1714
1990 2333
1991 2953
1992 3550
1993 4192
1994 5274
1995 6135
1996 6942
1997 7538
1998 8554
1999 9470
2000 10686
2001 11617
2002 12880
2003 14196
2004 15524
2005 16498
2006 18119
2007 19042
2008 20236
2009 21141
2010 22493
2011 24113
2012 25744
2013 27046
2014 27573
2015 27614
2016 27015
2017 27553
2018 27601
2019 25878
2020 12300
2021 2
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452,636 results
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Page 1
Mechanisms of Mineralocorticoid Receptor Signaling.
Fuller PJ, Yang J, Young MJ. Fuller PJ, et al. Vitam Horm. 2019;109:37-68. doi: 10.1016/bs.vh.2018.09.004. Epub 2018 Dec 1. Vitam Horm. 2019. PMID: 30678864 Review.
This chapter will provide a review of MR structure and function, and an analysis of the critical interactions involved in MR-mediated signal transduction, which contribute to ligand- and tissue-specificity. MR signal-transduction can be best viewed as …
This chapter will provide a review of MR structure and function, and an analysis of the critical interactions involved in MR-mediated sig
A Review on the Receptor-ligand Molecular Interactions in the Nicotinic Receptor Signaling Systems.
Liu W, Su K. Liu W, et al. Pak J Biol Sci. 2018;21(2):51-66. doi: 10.3923/pjbs.2018.51.66. Pak J Biol Sci. 2018. PMID: 30221881 Review.
Many nAChR subunits have been revealed to bind to either neurotransmitters or exogenous ligands, such as nicotine and acetylcholine, being involved in the nicotinic receptor signal transduction. ...Given numerous endeavours have been made in defining the role …
Many nAChR subunits have been revealed to bind to either neurotransmitters or exogenous ligands, such as nicotine and acetylcholine, being i …
Plant cell surface receptor-mediated signaling - a common theme amid diversity.
He Y, Zhou J, Shan L, Meng X. He Y, et al. J Cell Sci. 2018 Jan 29;131(2):jcs209353. doi: 10.1242/jcs.209353. J Cell Sci. 2018. PMID: 29378836 Free PMC article. Review.
In this Review, we summarize the emerging common theme that underlies cell surface receptor-mediated signaling pathways in Arabidopsisthaliana: the dynamic association of RLKs and RLPs with specific co-receptors and RLCKs for signal transduction
In this Review, we summarize the emerging common theme that underlies cell surface receptor-mediated signaling pathways in Ara …
The many faces of estrogen signaling.
Vrtačnik P, Ostanek B, Mencej-Bedrač S, Marc J. Vrtačnik P, et al. Biochem Med (Zagreb). 2014 Oct 15;24(3):329-42. doi: 10.11613/BM.2014.035. eCollection 2014. Biochem Med (Zagreb). 2014. PMID: 25351351 Free PMC article. Review.
Furthermore, there are several different mechanisms through which the three estrogen receptors (ERs), ERα, ERβ and G protein-coupled estrogen receptor 1 (GPER1) are able to regulate target gene transcription. ...Moreover, several coregulators of estrogen signalin
Furthermore, there are several different mechanisms through which the three estrogen receptors (ERs), ERα, ERβ and G protein-coupled …
Slit-Robo signaling.
Blockus H, Chédotal A. Blockus H, et al. Development. 2016 Sep 1;143(17):3037-44. doi: 10.1242/dev.132829. Development. 2016. PMID: 27578174 Free article. Review.
Slits are secreted proteins that bind to Roundabout (Robo) receptors. Slit-Robo signaling is best known for mediating axon repulsion in the developing nervous system. ...Likewise, our mechanistic understanding of Slit-Robo signaling has progressed enormously. …
Slits are secreted proteins that bind to Roundabout (Robo) receptors. Slit-Robo signaling is best known for mediating axon rep …
The Inositol Trisphosphate/Calcium Signaling Pathway in Health and Disease.
Berridge MJ. Berridge MJ. Physiol Rev. 2016 Oct;96(4):1261-96. doi: 10.1152/physrev.00006.2016. Physiol Rev. 2016. PMID: 27512009 Free article. Review.
Many cellular functions are regulated by calcium (Ca(2+)) signals that are generated by different signaling pathways. One of these is the inositol 1,4,5-trisphosphate/calcium (InsP3/Ca(2+)) signaling pathway that operates through either primary or modulatory …
Many cellular functions are regulated by calcium (Ca(2+)) signals that are generated by different signaling pathways. One of t …
Targeting G protein-coupled receptor signalling by blocking G proteins.
Campbell AP, Smrcka AV. Campbell AP, et al. Nat Rev Drug Discov. 2018 Nov;17(11):789-803. doi: 10.1038/nrd.2018.135. Epub 2018 Sep 28. Nat Rev Drug Discov. 2018. PMID: 30262890 Free PMC article. Review.
G protein-coupled receptors (GPCRs) are the largest class of drug targets, largely owing to their druggability, diversity and physiological efficacy. ...Additionally, because many GPCRs couple to multiple G protein signalling pathways, blocking specific G protein su …
G protein-coupled receptors (GPCRs) are the largest class of drug targets, largely owing to their druggability, diversity and physiol …
Orchestration of membrane receptor signaling by membrane lipids.
Arish M, Husein A, Kashif M, Sandhu P, Hasnain SE, Akhter Y, Rub A. Arish M, et al. Biochimie. 2015 Jun;113:111-24. doi: 10.1016/j.biochi.2015.04.005. Epub 2015 Apr 16. Biochimie. 2015. PMID: 25890158 Review.
Receptors on cell membrane bind to their respective ligands and transduce intracellular signals resulting in variety of effector functions. Membrane lipid composition determines the receptor signaling behavior, as the receptors assume different
Receptors on cell membrane bind to their respective ligands and transduce intracellular signals resulting in variety of effect
Inflammasomes: mechanism of assembly, regulation and signalling.
Broz P, Dixit VM. Broz P, et al. Nat Rev Immunol. 2016 Jul;16(7):407-20. doi: 10.1038/nri.2016.58. Epub 2016 Jun 13. Nat Rev Immunol. 2016. PMID: 27291964 Review.
Inflammasomes are multiprotein signalling platforms that control the inflammatory response and coordinate antimicrobial host defences. They are assembled by pattern-recognition receptors following the detection of pathogenic microorganisms and danger signals
Inflammasomes are multiprotein signalling platforms that control the inflammatory response and coordinate antimicrobial host defences …
Is the membrane estrogen receptor, GPER1, a promiscuous receptor that modulates nuclear estrogen receptor-mediated functions in the brain?
Vajaria R, Vasudevan N. Vajaria R, et al. Horm Behav. 2018 Aug;104:165-172. doi: 10.1016/j.yhbeh.2018.06.012. Epub 2018 Jul 19. Horm Behav. 2018. PMID: 29964007 Review.
Estrogen signals both slowly to regulate transcription and rapidly to activate kinases and regulate calcium levels. Both rapid, non-genomic signaling as well as genomic transcriptional signaling via intracellular estrogen receptors (ER)s can cha …
Estrogen signals both slowly to regulate transcription and rapidly to activate kinases and regulate calcium levels. Both rapid, non-g …
452,636 results
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