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Efficient colonic drug delivery in domestic pigs employing a tablet formulation with dual control concept.
Doggwiler V, Puorger C, Paredes V, Lanz M, Nuss KM, Lipps G, Imanidis G. Doggwiler V, et al. J Control Release. 2023 Jun;358:420-438. doi: 10.1016/j.jconrel.2023.04.047. Epub 2023 May 13. J Control Release. 2023. PMID: 37121513 Free article.
Peak concentration times (t(max)) and values (c(max)) of CCR 5-ASA and caffeine tablets indicated strongly delayed drug absorption and the deduced absorbed amount as a function of time confirmed absorption overwhelmingly from the large intestine. The microbia …
Peak concentration times (t(max)) and values (c(max)) of CCR 5-ASA and caffeine tablets indicated strongly delayed drug absorption …
Clinical pharmacokinetics of ergotamine in migraine and cluster headache.
Perrin VL. Perrin VL. Clin Pharmacokinet. 1985 Jul-Aug;10(4):334-52. doi: 10.2165/00003088-198510040-00004. Clin Pharmacokinet. 1985. PMID: 3899452 Review.
There is great interindividual variation in absorption of ergotamine in both patients and normal volunteers. Bioavailability is of the order of 5% or less by oral or rectal administration. ...Efficacy is greatest after parenteral administration, although adverse eff …
There is great interindividual variation in absorption of ergotamine in both patients and normal volunteers. Bioavailability is of th …
Systemic availability of ergotamine tartrate after oral, rectal and intramuscular administration.
Ala-Hurula V, Myllylä VV, Arvela P, Heikkilä J, Kärki N, Hokkanen E. Ala-Hurula V, et al. Eur J Clin Pharmacol. 1979 Feb 19;15(1):51-5. doi: 10.1007/BF00563557. Eur J Clin Pharmacol. 1979. PMID: 421728
Ergotamine tartrate was given in doses normally used in the treatment of acute migraine--2.0 mg orally, 2.0 mg combined with 100 mg caffeine rectally and 0.5 mg i.m. Plasma ergotamine concentrations were determined by radioimmunoassay. ...The corresponding maximum concentr …
Ergotamine tartrate was given in doses normally used in the treatment of acute migraine--2.0 mg orally, 2.0 mg combined with 100 mg caffe …