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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1972 1
1973 2
1974 1
1975 5
1976 4
1977 2
1978 2
1979 6
1980 2
1981 3
1982 6
1983 6
1984 10
1985 5
1986 6
1987 10
1988 3
1989 3
1990 6
1991 7
1992 13
1993 26
1994 23
1995 23
1996 31
1997 38
1998 43
1999 46
2000 67
2001 91
2002 88
2003 117
2004 132
2005 158
2006 168
2007 204
2008 207
2009 190
2010 273
2011 293
2012 330
2013 372
2014 388
2015 361
2016 351
2017 352
2018 403
2019 459
2020 480
2021 498
2022 385
2023 340
2024 373
2025 503
2026 97

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7,048 results

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Page 1
ROS function in redox signaling and oxidative stress.
Schieber M, Chandel NS. Schieber M, et al. Curr Biol. 2014 May 19;24(10):R453-62. doi: 10.1016/j.cub.2014.03.034. Curr Biol. 2014. PMID: 24845678 Free PMC article. Review.
Oxidative stress has been linked to a myriad of pathologies. However, elevated ROS also act as signaling molecules in the maintenance of physiological functions--a process termed redox biology. ...Redox biology involves a small increase in ROS levels t …
Oxidative stress has been linked to a myriad of pathologies. However, elevated ROS also act as signaling molecules in the main …
Oxidative stress: a concept in redox biology and medicine.
Sies H. Sies H. Redox Biol. 2015;4:180-3. doi: 10.1016/j.redox.2015.01.002. Epub 2015 Jan 3. Redox Biol. 2015. PMID: 25588755 Free PMC article. Review.
Current research on molecular redox switches governing oxidative stress responses is in full bloom. The fundamental importance of linking redox shifts to phosphorylation/dephosphorylation signaling is being more fully appreciated, thanks to major advances in …
Current research on molecular redox switches governing oxidative stress responses is in full bloom. The fundamental importance of lin …
Regulating Nrf2 activity: ubiquitin ligases and signaling molecules in redox homeostasis.
Hayes JD, Dayalan Naidu S, Dinkova-Kostova AT. Hayes JD, et al. Trends Biochem Sci. 2025 Mar;50(3):179-205. doi: 10.1016/j.tibs.2024.12.010. Epub 2025 Jan 27. Trends Biochem Sci. 2025. PMID: 39875264 Free article. Review.
We discuss how Nrf2 activity is controlled by the ubiquitin ligases under different circumstances. We also describe endogenous signaling molecules that inactivate CRL3(Keap1) to alleviate stress and restore homeostasis....
We discuss how Nrf2 activity is controlled by the ubiquitin ligases under different circumstances. We also describe endogenous signaling …
Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress.
Sies H. Sies H. Redox Biol. 2017 Apr;11:613-619. doi: 10.1016/j.redox.2016.12.035. Epub 2017 Jan 5. Redox Biol. 2017. PMID: 28110218 Free PMC article. Review.
Hydrogen peroxide emerged as major redox metabolite operative in redox sensing, signaling and redox regulation. Generation, transport and capture of H(2)O(2) in biological settings as well as their biological consequences can now be addressed. ...What …
Hydrogen peroxide emerged as major redox metabolite operative in redox sensing, signaling and redox regulation. …
Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling.
Ray PD, Huang BW, Tsuji Y. Ray PD, et al. Cell Signal. 2012 May;24(5):981-90. doi: 10.1016/j.cellsig.2012.01.008. Epub 2012 Jan 20. Cell Signal. 2012. PMID: 22286106 Free PMC article. Review.
Paradoxically, accumulating evidence indicates that ROS also serve as critical signaling molecules in cell proliferation and survival. While there is a large body of research demonstrating the general effect of oxidative stress on signaling pathways, less is …
Paradoxically, accumulating evidence indicates that ROS also serve as critical signaling molecules in cell proliferation and s …
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents.
Sies H, Jones DP. Sies H, et al. Nat Rev Mol Cell Biol. 2020 Jul;21(7):363-383. doi: 10.1038/s41580-020-0230-3. Epub 2020 Mar 30. Nat Rev Mol Cell Biol. 2020. PMID: 32231263 Review.
In addition, several other reactive species are involved in redox signalling, for instance nitric oxide, hydrogen sulfide and oxidized lipids. Recent methodological advances permit the assessment of molecular interactions of specific ROS molecules with specif …
In addition, several other reactive species are involved in redox signalling, for instance nitric oxide, hydrogen sulfide and …
Targeting oxidative stress in disease: promise and limitations of antioxidant therapy.
Forman HJ, Zhang H. Forman HJ, et al. Nat Rev Drug Discov. 2021 Sep;20(9):689-709. doi: 10.1038/s41573-021-00233-1. Epub 2021 Jun 30. Nat Rev Drug Discov. 2021. PMID: 34194012 Free PMC article. Review.
Oxidative stress is a component of many diseases, including atherosclerosis, chronic obstructive pulmonary disease, Alzheimer disease and cancer. Although numerous small molecules evaluated as antioxidants have exhibited therapeutic potential in preclinical studies, clinic …
Oxidative stress is a component of many diseases, including atherosclerosis, chronic obstructive pulmonary disease, Alzheimer disease and ca …
Cellular Redox Compartments.
Kietzmann T. Kietzmann T. Antioxid Redox Signal. 2019 Jan 1;30(1):1-4. doi: 10.1089/ars.2018.7661. Epub 2018 Oct 30. Antioxid Redox Signal. 2019. PMID: 30259756
Although initially considered as harmful, reactive oxygen species (ROS) are now also recognized as important signaling molecules affecting various cellular processes. For example, they contribute to the response to hormones, growth factors, or hypoxia, and defense r …
Although initially considered as harmful, reactive oxygen species (ROS) are now also recognized as important signaling molecules …
Reactive Oxygen Species in Plant Signaling.
Waszczak C, Carmody M, Kangasjärvi J. Waszczak C, et al. Annu Rev Plant Biol. 2018 Apr 29;69:209-236. doi: 10.1146/annurev-arplant-042817-040322. Epub 2018 Feb 28. Annu Rev Plant Biol. 2018. PMID: 29489394 Review.
Initially considered by-products from aerobic metabolism, reactive oxygen species (ROS) have emerged as major regulatory molecules in plants and their roles in early signaling events initiated by cellular metabolic perturbation and environmental stimuli are now esta …
Initially considered by-products from aerobic metabolism, reactive oxygen species (ROS) have emerged as major regulatory molecules in …
Extracellular Matrix and Redox Signaling in Cellular Responses to Stress.
Roberts DD. Roberts DD. Antioxid Redox Signal. 2017 Oct 20;27(12):771-773. doi: 10.1089/ars.2017.7308. Epub 2017 Sep 6. Antioxid Redox Signal. 2017. PMID: 28793792 Free PMC article.
These proteins engage specific cell surface signaling receptors, integrins, and proteoglycans to regulate the biosynthesis and catabolism of redox signaling molecules and the activation of their signal transducers. These signaling pathway …
These proteins engage specific cell surface signaling receptors, integrins, and proteoglycans to regulate the biosynthesis and catabo …
7,048 results