Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1973 1
1975 2
1976 2
1979 3
1980 3
1981 3
1982 2
1983 1
1984 7
1985 2
1986 3
1987 9
1988 6
1989 6
1990 7
1991 13
1992 8
1993 12
1994 7
1995 29
1996 21
1997 25
1998 34
1999 32
2000 33
2001 21
2002 29
2003 51
2004 54
2005 58
2006 42
2007 58
2008 67
2009 58
2010 53
2011 44
2012 49
2013 52
2014 41
2015 39
2016 35
2017 24
2018 25
2019 32
2020 31
2021 29
2022 24
2023 17
2024 32

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

1,112 results

Results by year

Filters applied: . Clear all
Page 1
Methotrexate recognition by the human reduced folate carrier SLC19A1.
Wright NJ, Fedor JG, Zhang H, Jeong P, Suo Y, Yoo J, Hong J, Im W, Lee SY. Wright NJ, et al. Nature. 2022 Sep;609(7929):1056-1062. doi: 10.1038/s41586-022-05168-0. Epub 2022 Sep 7. Nature. 2022. PMID: 36071163 Free PMC article.
Folates are essential nutrients with important roles as cofactors in one-carbon transfer reactions, being heavily utilized in the synthesis of nucleic acids and the metabolism of amino acids during cell division(1,2). Mammals lack de novo folate synthesis pathways and thus …
Folates are essential nutrients with important roles as cofactors in one-carbon transfer reactions, being heavily utilized in the synthesis …
Reduced folate carrier 1 is present in retinal microvessels and crucial for the inner blood retinal barrier integrity.
Gurler G, Belder N, Beker MC, Sever-Bahcekapili M, Uruk G, Kilic E, Yemisci M. Gurler G, et al. Fluids Barriers CNS. 2023 Jun 16;20(1):47. doi: 10.1186/s12987-023-00442-3. Fluids Barriers CNS. 2023. PMID: 37328777 Free PMC article.
BACKGROUND: Reduced folate carrier 1 (RFC1; SLC19a1) is the main responsible transporter for the B9 family of vitamins named folates, which are essential for normal tissue growth and development. ...Hence, other than being a folate carrier, RFC1 …
BACKGROUND: Reduced folate carrier 1 (RFC1; SLC19a1) is the main responsible transporter for the B9 family of vitamins …
Reduced folate carrier: biochemistry and molecular biology of the normal and methotrexate-resistant cell.
Bosson G. Bosson G. Br J Biomed Sci. 2003;60(2):117-29. doi: 10.1080/09674845.2003.11783687. Br J Biomed Sci. 2003. PMID: 12866924 Review.
Resistance to methotrexate can be achieved by altering the genetic code of the reduced folate carrier gene and thus change the structure and function of the protein. ...The aim of this essay is to explain the structure and function of the reduced …
Resistance to methotrexate can be achieved by altering the genetic code of the reduced folate carrier gene and thus cha …
Reduced folate carrier-mediated methotrexate transport in human distal lung epithelial NCl-H441 cells.
Kawami M, Honda N, Miyamoto M, Yumoto R, Takano M. Kawami M, et al. J Pharm Pharmacol. 2019 Feb;71(2):167-175. doi: 10.1111/jphp.13022. Epub 2018 Oct 15. J Pharm Pharmacol. 2019. PMID: 30324648
OBJECTIVES: We had previously found that reduced folate carrier (RFC; SLC19A1) is mainly involved in an influx of transport of methotrexate (MTX), a folate analogue, using alveolar epithelial A549 cells. ...
OBJECTIVES: We had previously found that reduced folate carrier (RFC; SLC19A1) is mainly involved in an influx of trans …
SLC19A1 transports immunoreactive cyclic dinucleotides.
Luteijn RD, Zaver SA, Gowen BG, Wyman SK, Garelis NE, Onia L, McWhirter SM, Katibah GE, Corn JE, Woodward JJ, Raulet DH. Luteijn RD, et al. Nature. 2019 Sep;573(7774):434-438. doi: 10.1038/s41586-019-1553-0. Epub 2019 Sep 11. Nature. 2019. PMID: 31511694 Free PMC article.
Here we used a genome-wide CRISPR-interference screen to identify the reduced folate carrier SLC19A1, a folate-organic phosphate antiporter, as the major transporter of CDNs. ...
Here we used a genome-wide CRISPR-interference screen to identify the reduced folate carrier SLC19A1, a folate-o …
Human reduced folate carrier: translation of basic biology to cancer etiology and therapy.
Matherly LH, Hou Z, Deng Y. Matherly LH, et al. Cancer Metastasis Rev. 2007 Mar;26(1):111-28. doi: 10.1007/s10555-007-9046-2. Cancer Metastasis Rev. 2007. PMID: 17334909 Review.
This review attempts to provide a comprehensive overview of the biology of the physiologically and pharmacologically important transport system termed the "reduced folate carrier" (RFC). The ubiquitously expressed RFC has unequivocally established itself as t …
This review attempts to provide a comprehensive overview of the biology of the physiologically and pharmacologically important transport sys …
Reduced Folate Carrier: an Entry Receptor for a Novel Feline Leukemia Virus Variant.
Miyake A, Kawasaki J, Ngo H, Makundi I, Muto Y, Khan AH, Smith DJ, Nishigaki K. Miyake A, et al. J Virol. 2019 Jun 14;93(13):e00269-19. doi: 10.1128/JVI.00269-19. Print 2019 Jul 1. J Virol. 2019. PMID: 30996094 Free PMC article.
Retrovirus entry into cells is mediated by the interaction of envelope protein (Env) with specific cell surface receptors. Here, phenotypic screening of a human/hamster radiation hybrid panel identified SLC19A1, a feline reduced folate carrier (RFC) an …
Retrovirus entry into cells is mediated by the interaction of envelope protein (Env) with specific cell surface receptors. Here, phen …
Molecular and cellular biology of the human reduced folate carrier.
Matherly LH. Matherly LH. Prog Nucleic Acid Res Mol Biol. 2001;67:131-62. doi: 10.1016/s0079-6603(01)67027-2. Prog Nucleic Acid Res Mol Biol. 2001. PMID: 11525381 Review.
Many key in vitro findings have now begun to be extended to studies of reduced folate carrier levels and function in patient specimens, paving the way for translating basic laboratory studies in cultured cells to improvements in human health and treatment of …
Many key in vitro findings have now begun to be extended to studies of reduced folate carrier levels and function in pa …
Association of maternal folate use and reduced folate carrier gene polymorphisms with the risk of congenital heart disease in offspring.
Qin J, Li J, Li F, Sun M, Wang T, Diao J, Zhang S, Luo L, Li Y, Chen L, Huang P, Zhu P. Qin J, et al. Eur J Pediatr. 2021 Oct;180(10):3181-3190. doi: 10.1007/s00431-021-04087-y. Epub 2021 Apr 29. Eur J Pediatr. 2021. PMID: 33913025
This study aimed to investigate the association of maternal folate use, the time when folate use was started, and polymorphisms of the reduced folate carrier (RFC1) gene with the risk of CHD in offspring of Chinese descent, which can help provid …
This study aimed to investigate the association of maternal folate use, the time when folate use was started, and polymorphism …
1,112 results