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89 results

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Page 1
Reduced Vitamin K Status as a Potentially Modifiable Risk Factor of Severe Coronavirus Disease 2019.
Dofferhoff ASM, Piscaer I, Schurgers LJ, Visser MPJ, van den Ouweland JMW, de Jong PA, Gosens R, Hackeng TM, van Daal H, Lux P, Maassen C, Karssemeijer EGA, Vermeer C, Wouters EFM, Kistemaker LEM, Walk J, Janssen R. Dofferhoff ASM, et al. Clin Infect Dis. 2021 Dec 6;73(11):e4039-e4046. doi: 10.1093/cid/ciaa1258. Clin Infect Dis. 2021. PMID: 32852539 Free PMC article.
Vitamin K-dependent carboxylation.
Berkner KL. Berkner KL. Vitam Horm. 2008;78:131-56. doi: 10.1016/S0083-6729(07)00007-6. Vitam Horm. 2008. PMID: 18374193 Review.
Vitamin K oxidoreductase (VKOR), the target of warfarin, generates the reduced vitamin K cofactor used by the carboxylase. Oxidation of active site thiols during vitamin K reduction inactivates VKOR, and activity is regenerated by an unknown reductase. The am …
Vitamin K oxidoreductase (VKOR), the target of warfarin, generates the reduced vitamin K cofactor used by the carboxyla …
Vitamin K-Dependent Protein Activation: Normal Gamma-Glutamyl Carboxylation and Disruption in Disease.
Berkner KL, Runge KW. Berkner KL, et al. Int J Mol Sci. 2022 May 20;23(10):5759. doi: 10.3390/ijms23105759. Int J Mol Sci. 2022. PMID: 35628569 Free PMC article. Review.
The gamma-glutamyl carboxylase produces Gla using reduced vitamin K, which becomes oxygenated to vitamin K epoxide. Reduced vitamin K is then regenerated by a vitamin K oxidoreductase (VKORC1), and this interconversion of oxygenated and …
The gamma-glutamyl carboxylase produces Gla using reduced vitamin K, which becomes oxygenated to vitamin K epoxide. …
The vitamin K-dependent carboxylase.
Berkner KL. Berkner KL. Annu Rev Nutr. 2005;25:127-49. doi: 10.1146/annurev.nutr.25.050304.092713. Annu Rev Nutr. 2005. PMID: 16011462 Review.
Warfarin inhibits a vitamin K oxidoreductase that generates the reduced vitamin K cofactor required for continuous carboxylation and causes decreased carboxylase catalysis and increased dissociation of partially carboxylated, inactive VKD proteins. The availa …
Warfarin inhibits a vitamin K oxidoreductase that generates the reduced vitamin K cofactor required for continuous carb …
The vitamin K cycle.
Stafford DW. Stafford DW. J Thromb Haemost. 2005 Aug;3(8):1873-8. doi: 10.1111/j.1538-7836.2005.01419.x. J Thromb Haemost. 2005. PMID: 16102054 Free article. Review.
Carboxylation is accomplished by the enzyme gamma glutamyl carboxylase (GGCX) which requires the propeptide-containing substrate and three co-substrates: reduced vitamin K, CO2, and O2. Most propeptides bind tightly to GGCX and all of the Glu residues that wi …
Carboxylation is accomplished by the enzyme gamma glutamyl carboxylase (GGCX) which requires the propeptide-containing substrate and three c …
Vitamin K: a potential missing link in critical illness-a scoping review.
Paulus MC, Drent M, Kouw IWK, Balvers MGJ, Bast A, van Zanten ARH. Paulus MC, et al. Crit Care. 2024 Jul 1;28(1):212. doi: 10.1186/s13054-024-05001-2. Crit Care. 2024. PMID: 38956732 Free PMC article. Review.
Observational studies show higher PIVKA-II levels in ICU patients, indicating reduced vitamin K status. Risk factors include inadequate intake, disrupted absorption, and increased physiological demands. ...
Observational studies show higher PIVKA-II levels in ICU patients, indicating reduced vitamin K status. Risk factors in …
Vitamin K-dependent gamma-glutamylcarboxylation: an ancient posttranslational modification.
Bandyopadhyay PK. Bandyopadhyay PK. Vitam Horm. 2008;78:157-84. doi: 10.1016/S0083-6729(07)00008-8. Vitam Horm. 2008. PMID: 18374194 Review.
The vitamin K-dependent carboxylase carries out the posttranslational modification of specific glutamate residues in proteins to gamma-carboxy glutamic acid (Gla) in the presence of reduced vitamin K, molecular oxygen, and carbon dioxide. In the process, r …
The vitamin K-dependent carboxylase carries out the posttranslational modification of specific glutamate residues in proteins to gamma-carbo …
Quinone oxidoreductases and vitamin K metabolism.
Gong X, Gutala R, Jaiswal AK. Gong X, et al. Vitam Horm. 2008;78:85-101. doi: 10.1016/S0083-6729(07)00005-2. Vitam Horm. 2008. PMID: 18374191 Review.
Vitamin K hydroquinone serves as a cofactor for vitamin K gamma-carboxylase that catalyzes gamma-carboxylation of specific glutamic acid residues in Gla-factors/proteins leading to their activation and participation in blood clotting and bone metabolism. Concomitant with Gla modi …
Vitamin K hydroquinone serves as a cofactor for vitamin K gamma-carboxylase that catalyzes gamma-carboxylation of specific glutamic acid res …
VKORC1L1, An Enzyme Mediating the Effect of Vitamin K in Liver and Extrahepatic Tissues.
Lacombe J, Ferron M. Lacombe J, et al. Nutrients. 2018 Jul 26;10(8):970. doi: 10.3390/nu10080970. Nutrients. 2018. PMID: 30050002 Free PMC article. Review.
Vitamin K oxidoreductase (VKORC1) converts vitamin K epoxide into reduced vitamin K, which acts as the co-factor for the gamma-carboxylation of several proteins, including coagulation factors produced by the liver. ...
Vitamin K oxidoreductase (VKORC1) converts vitamin K epoxide into reduced vitamin K, which acts as the co-factor for th …
89 results