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Page 1
Refractory sprue.
Culliford AN, Green PH. Culliford AN, et al. Curr Gastroenterol Rep. 2003 Oct;5(5):373-8. doi: 10.1007/s11894-003-0049-z. Curr Gastroenterol Rep. 2003. PMID: 12959717 Review.
The detection of aberrant, clonally expanded, intraepithelial lymphocytes has led to better definition and classification of patients with refractory sprue. ...The presence of an aberrant clonal intraepithelial T-cell population has led t …
The detection of aberrant, clonally expanded, intraepithelial lymphocytes has led to better definition and classificati …
The combination of clinical parameters and immunophenotyping of intraepithelial lymphocytes allows to assess disease severity in refractory celiac disease.
Branchi F, Wiese JJ, Heldt C, Manna S, Dony V, Loddenkemper C, Bojarski C, Siegmund B, Schneider T, Daum S, Hummel M, Moos V, Schumann M. Branchi F, et al. Dig Liver Dis. 2022 Dec;54(12):1649-1656. doi: 10.1016/j.dld.2022.06.024. Epub 2022 Jul 15. Dig Liver Dis. 2022. PMID: 35850920
AIMS: To investigate possible associations between clinical characteristics of refractory celiac disease patients and aberrant intraepithelial lymphocytes and to evaluate the accuracy of immunophenotyping for the identification of high-risk r …
AIMS: To investigate possible associations between clinical characteristics of refractory celiac disease patients and aberr …
Flow cytometry for the assessment and monitoring of aberrant intraepithelial lymphocytes in non-responsive celiac disease and non-celiac enteropathies.
Schiepatti A, Maimaris S, Scarcella C, Pignatti P, Betti E, Shoval Y, Arpa G, Ciccocioppo R, Biagi F. Schiepatti A, et al. Dig Liver Dis. 2024 May;56(5):795-801. doi: 10.1016/j.dld.2023.10.025. Epub 2023 Nov 13. Dig Liver Dis. 2024. PMID: 37968145 Free article.
BACKGROUND: Few data are available on flow cytometry (FC) for monitoring intraepithelial lymphocytes (IELs) in refractory celiac disease (RCD), non-responsive celiac disease (NRCD), and non-celiac enteropathies (NCEs). ...METHODS: Patient …
BACKGROUND: Few data are available on flow cytometry (FC) for monitoring intraepithelial lymphocytes (IELs) in refractory …
Aberrant T-lymphocytes in refractory coeliac disease are not strictly confined to a small intestinal intraepithelial localization.
Verbeek WH, von Blomberg BM, Coupe VM, Daum S, Mulder CJ, Schreurs MW. Verbeek WH, et al. Cytometry B Clin Cytom. 2009 Nov;76(6):367-74. doi: 10.1002/cyto.b.20481. Cytometry B Clin Cytom. 2009. PMID: 19444812 Free article.
BACKGROUND: Refractory coeliac disease (RCD) is characterized by persisting mucosal pathology in spite of a strict gluten free diet (GFD). ...AIM: To investigate whether aberrant T-lymphocytes in RCD II can be detected in other parts of the small intes …
BACKGROUND: Refractory coeliac disease (RCD) is characterized by persisting mucosal pathology in spite of a strict gluten free …
The Intracellular Intensity of CD3 on Aberrant Intraepithelial Lymphocytes Is a Prognostic Factor of the Progression to Overt Lymphoma in Refractory Celiac Disease Type II (Pre-Enteropathy-Associated T Cell Lymphoma).
García-Hoz C, Crespo L, Lopez N, De Andrés A, Ríos León R, Santón A, Garriga M, Butz E, León F, Roy Ariño G. García-Hoz C, et al. Dig Dis. 2020;38(6):490-499. doi: 10.1159/000506305. Epub 2020 Feb 4. Dig Dis. 2020. PMID: 32015237
BACKGROUND: Refractory celiac disease type II (RCD-II) is a very rare yet severe complication of celiac disease (CD) with a 50% rate of progression to Enteropathy-associated T-cell lymphoma (EATL). Timely diagnosis and treatment of RCD-II is of the essence an …
BACKGROUND: Refractory celiac disease type II (RCD-II) is a very rare yet severe complication of celiac disease (CD) wi …
Refractory Celiac Disease: What the Gastroenterologist Should Know.
Verdelho Machado M. Verdelho Machado M. Int J Mol Sci. 2024 Sep 26;25(19):10383. doi: 10.3390/ijms251910383. Int J Mol Sci. 2024. PMID: 39408713 Free PMC article. Review.
Fewer than 1% of patients with celiac disease (CD) will develop refractory CD (RCD). As such, most gastroenterologists might never need to manage patients with RCD. ...
Fewer than 1% of patients with celiac disease (CD) will develop refractory CD (RCD). As such, most gastroenterologists might n …
Aberrant intra-epithelial lymphocytes cause enterocyte cell death in refractory celiac disease by CD103-beta7-receptor-mediated granzyme-B degranulation which can be restored by etrolizumab.
Castelijn DAR, van de Water JMW, de Baaij LR, McGlinchy BS, van Leeuwen M, Joosten SPJ, Alberts N, Rossi M, Reijm M, Hollander JC, Bonnet P, Kooy-Winkelaar YMC, Koning F, Pals ST, Bouma G, Meijer CJLM, Bontkes HJ, Mulder CJJ, Cillessen SAGM. Castelijn DAR, et al. Clin Transl Immunology. 2026 May 14;15:e70099. doi: 10.1002/cti2.70099. eCollection 2026. Clin Transl Immunology. 2026. PMID: 42146106 Free PMC article.
OBJECTIVES: Refractory celiac disease type II (RCDII) is an intestinal tumor of aberrant intra-epithelial T-lymphocytes (IEL). ...RESULTS: Levels of granzyme-B expression were significantly upregulated in aberrant IEL of RCDII patients compared …
OBJECTIVES: Refractory celiac disease type II (RCDII) is an intestinal tumor of aberrant intra-epithelial T-lymphocy …
Mucosal intraepithelial T-lymphocytes in refractory celiac disease: a neoplastic population with a variable CD8 phenotype.
de Mascarel A, Belleannée G, Stanislas S, Merlio C, Parrens M, Laharie D, Dubus P, Merlio JP. de Mascarel A, et al. Am J Surg Pathol. 2008 May;32(5):744-51. doi: 10.1097/PAS.0b013e318159b478. Am J Surg Pathol. 2008. PMID: 18360280
Celiac disease (CD) is characterized by villous atrophy and an increase in intraepithelial lymphocytes (IEL). The IEL usually exhibit a suppressor/cytotoxic phenotype (CD3 and CD8) and display a polyclonal profile for T-cell receptor (TCR) rearrangement as op …
Celiac disease (CD) is characterized by villous atrophy and an increase in intraepithelial lymphocytes (IEL). The IEL u …
Recurrent partial trisomy 1q22-q44 in clonal intraepithelial lymphocytes in refractory celiac sprue.
Verkarre V, Romana SP, Cellier C, Asnafi V, Mention JJ, Barbe U, Nusbaum S, Hermine O, Macintyre E, Brousse N, Cerf-Bensussan N, Radford-Weiss I. Verkarre V, et al. Gastroenterology. 2003 Jul;125(1):40-6. doi: 10.1016/s0016-5085(03)00692-9. Gastroenterology. 2003. PMID: 12851869
BACKGROUND & AIMS: Refractory celiac sprue, a low-grade intraepithelial lymphoma characterized by expansion of clonal intraepithelial lymphocytes with intracellular CD3 epsilon but no surface CD3-T-cell receptor complexes, can be an intermed …
BACKGROUND & AIMS: Refractory celiac sprue, a low-grade intraepithelial lymphoma characterized by expansion of clon …
Cellular and molecular bases of refractory celiac disease.
Soderquist CR, Bhagat G. Soderquist CR, et al. Int Rev Cell Mol Biol. 2021;358:207-240. doi: 10.1016/bs.ircmb.2020.12.001. Epub 2021 Feb 13. Int Rev Cell Mol Biol. 2021. PMID: 33707055 Review.
Refractory celiac disease (RCD) encompasses biologically heterogeneous disorders that develop in a small proportion (0.3%) of individuals with celiac disease that are associated with high morbidity. Two broad categories are currently recognized, type I (RCD I …
Refractory celiac disease (RCD) encompasses biologically heterogeneous disorders that develop in a small proportion (0.3%) of …
51 results