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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 2
1990 1
1991 1
1992 4
1993 2
1994 15
1995 27
1996 48
1997 79
1998 89
1999 122
2000 183
2001 153
2002 218
2003 259
2004 264
2005 297
2006 324
2007 295
2008 297
2009 330
2010 324
2011 332
2012 424
2013 472
2014 433
2015 384
2016 385
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2018 369
2019 338
2020 297
2021 260
2022 129
2023 131
2024 168
2025 218
2026 136

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7,403 results

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Page 1
Leptin signalling.
Sweeney G. Sweeney G. Cell Signal. 2002 Aug;14(8):655-63. doi: 10.1016/s0898-6568(02)00006-2. Cell Signal. 2002. PMID: 12020765 Review.
These effects are mediated via a family of cytokine-like receptor isoforms distributed in both the central nervous system and periphery. The signal transduction pathways regulated by leptin are diverse and include those characteristic of both cytokine and gro …
These effects are mediated via a family of cytokine-like receptor isoforms distributed in both the central nervous system and periphery. The …
Piezo1 regulates intestinal epithelial function by affecting the tight junction protein claudin-1 via the ROCK pathway.
Jiang Y, Song J, Xu Y, Liu C, Qian W, Bai T, Hou X. Jiang Y, et al. Life Sci. 2021 Jun 15;275:119254. doi: 10.1016/j.lfs.2021.119254. Epub 2021 Feb 24. Life Sci. 2021. PMID: 33636174
KEY FINDINGS: Alteration of Piezo1 expression altered epithelial function and the expression of the tight junction protein claudin-1. Piezo1 expression regulated phosphorylated ROCK1/2 expression, whereas interference on ROCK1/2 prevented the regulation of cl …
KEY FINDINGS: Alteration of Piezo1 expression altered epithelial function and the expression of the tight junction protein claudin-1. …
Regulation and functions of Rho-associated kinase.
Amano M, Fukata Y, Kaibuchi K. Amano M, et al. Exp Cell Res. 2000 Nov 25;261(1):44-51. doi: 10.1006/excr.2000.5046. Exp Cell Res. 2000. PMID: 11082274 Review.
Remarkable progress has been made in understanding effector molecules of small GTPase Rho, especially Rho-associated kinase (Rho-kinase/ROK/ROCK), in the past 5 years. Rho-associated kinase appears to mediate a large proportion of the signals from R …
Remarkable progress has been made in understanding effector molecules of small GTPase Rho, especially Rho-associated kinase ( …
Role of Rho-specific guanine nucleotide dissociation inhibitor alpha regulation in cell migration.
Xie F, Shao S, Aziz AUR, Zhang B, Wang H, Liu B. Xie F, et al. Acta Histochem. 2017 Apr;119(3):183-189. doi: 10.1016/j.acthis.2017.01.008. Epub 2017 Feb 8. Acta Histochem. 2017. PMID: 28187905 Review.
Cell migration is a vital process for many physiological and pathological events, and Rho GTPases have been confirmed as key factors in its regulation. The most studied negative regulator of Rho GTPases, Rho-specific guanine nucleotide dissociat …
Cell migration is a vital process for many physiological and pathological events, and Rho GTPases have been confirmed as key factors …
Regulation of Rho proteins by phosphorylation in the cardiovascular system.
Loirand G, Guilluy C, Pacaud P. Loirand G, et al. Trends Cardiovasc Med. 2006 Aug;16(6):199-204. doi: 10.1016/j.tcm.2006.03.010. Trends Cardiovasc Med. 2006. PMID: 16839863 Review.
The small G protein Rho signaling pathways are recognized as major regulators of cardiovascular functions, and activation of Rho proteins appears to be a common component for the pathogenesis of hypertension and vascular proliferative disorders. …
The small G protein Rho signaling pathways are recognized as major regulators of cardiovascular functions, and activati …
Membrane/cytoskeleton communication.
Meiri KF. Meiri KF. Subcell Biochem. 2004;37:247-82. doi: 10.1007/978-1-4757-5806-1_8. Subcell Biochem. 2004. PMID: 15376624 Review.
Accumulations of particular lipids in ordered arrays in the membrane (termed microdomains or lipid rafts) can attract proteins with specific targeting domains. Both the lipid and protein components of rafts communicate with the cytoskeleton directly thereby regul …
Accumulations of particular lipids in ordered arrays in the membrane (termed microdomains or lipid rafts) can attract proteins with s …
Regulation of Cdc42 protein turnover modulates the filamentous growth MAPK pathway.
González B, Cullen PJ. González B, et al. J Cell Biol. 2022 Dec 5;221(12):e202112100. doi: 10.1083/jcb.202112100. Epub 2022 Nov 9. J Cell Biol. 2022. PMID: 36350310 Free PMC article.
Rho GTPases are central regulators of cell polarity and signaling. How Rho GTPases are directed to function in certain settings remains unclear. Here, we show the protein levels of the yeast Rho GTPase Cdc42p are regulated, which impacts …
Rho GTPases are central regulators of cell polarity and signaling. How Rho GTPases are directed to function in certain …
Signal transduction through the GTP-binding proteins Rac and Rho.
Ridley AJ. Ridley AJ. J Cell Sci Suppl. 1994;18:127-31. doi: 10.1242/jcs.1994.supplement_18.19. J Cell Sci Suppl. 1994. PMID: 7883787 Review.
In Swiss 3T3 fibroblasts, the Ras-related GTP-binding proteins Rho and Rac act as key signal transducers in these responses: Rho is required for growth factor-induced formation of stress fibres and focal adhesions, whereas membrane ruffling is regul …
In Swiss 3T3 fibroblasts, the Ras-related GTP-binding proteins Rho and Rac act as key signal transducers in these respo …
Cell cycle regulation of Rho signaling pathways.
David M, Petit D, Bertoglio J. David M, et al. Cell Cycle. 2012 Aug 15;11(16):3003-10. doi: 10.4161/cc.21088. Epub 2012 Jul 24. Cell Cycle. 2012. PMID: 22825247 Free PMC article. Review.
The dynamics of the actin cytoskeleton and its regulation by Rho GTPases are essential to maintain cell shape, to allow cell motility and are also critical during cell cycle progression and mitosis. ...Recent studies have revealed how a number of nucleotide exchange …
The dynamics of the actin cytoskeleton and its regulation by Rho GTPases are essential to maintain cell shape, to allow cell m …
[Role of Rho GTPases in the immune regulation of infection and inflammation].
Wei Z, Jun-Qi Y. Wei Z, et al. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2017 Dec 26;29(6):807-813. doi: 10.16250/j.32.1374.2017030. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2017. PMID: 29469473 Review. Chinese.
The Rho subfamily of GTPase belongs to the Ras superfamily of small GTP binding protein, it is a nucleotide dependent protein, which plays a "molecular switch" function in the signal transduction process and control of numerous signaling …
The Rho subfamily of GTPase belongs to the Ras superfamily of small GTP binding protein, it is a nucleotide dependent prote …
7,403 results