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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 2
1991 1
1992 13
1993 33
1994 75
1995 143
1996 205
1997 264
1998 272
1999 364
2000 409
2001 396
2002 400
2003 408
2004 446
2005 438
2006 444
2007 453
2008 453
2009 445
2010 512
2011 508
2012 509
2013 496
2014 518
2015 556
2016 457
2017 409
2018 384
2019 398
2020 367
2021 342
2022 220
2023 212
2024 258
2025 286
2026 170

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11,117 results

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Page 1
Cell cycle proteins as promising targets in cancer therapy.
Otto T, Sicinski P. Otto T, et al. Nat Rev Cancer. 2017 Jan 27;17(2):93-115. doi: 10.1038/nrc.2016.138. Nat Rev Cancer. 2017. PMID: 28127048 Free PMC article. Review.
Cancer is characterized by uncontrolled tumour cell proliferation resulting from aberrant activity of various cell cycle proteins. Therefore, cell cycle regulators are considered attractive targets in cancer therapy. ...After decades of research on the physiological …
Cancer is characterized by uncontrolled tumour cell proliferation resulting from aberrant activity of various cell cycle proteins. Th …
A patent review of cyclin-dependent kinase 7 (CDK7) inhibitors (2018-2022).
Kovalová M, Baraka JP, Mik V, Jorda R, Luo L, Shao H, Kryštof V. Kovalová M, et al. Expert Opin Ther Pat. 2023 Feb;33(2):67-87. doi: 10.1080/13543776.2023.2195547. Epub 2023 Apr 10. Expert Opin Ther Pat. 2023. PMID: 36975020 Free article. Review.
INTRODUCTION: Cyclin-dependent kinase 7 (CDK7) is a member of the CDK family of serine/threonine protein kinases and participates in the regulation of the cell cycle and mRNA transcription. ...Highly potent and selective inh …
INTRODUCTION: Cyclin-dependent kinase 7 (CDK7) is a member of the CDK family of serine/threonine prote …
Structure-based design of cyclin-dependent kinase inhibitors.
Davies TG, Pratt DJ, Endicott JA, Johnson LN, Noble ME. Davies TG, et al. Pharmacol Ther. 2002 Feb-Mar;93(2-3):125-33. doi: 10.1016/s0163-7258(02)00182-1. Pharmacol Ther. 2002. PMID: 12191605 Review.
The eukaryotic cell cycle is tightly regulated by the sequential activation and deactivation of the cyclin-dependent kinases (CDKs). ...The strong genetic link between CDKs and the molecular pathology of cancer has provided the rationale for dev …
The eukaryotic cell cycle is tightly regulated by the sequential activation and deactivation of the cyclin-dependent …
Activation of the ciliary kinase CDKL5 is mediated by the cyclin-dependent kinase CDK20/LF2 to control flagellar length.
Hou Y, Omi OA, Stuck MW, Cheng X, Walker B, Lam YW, Schmoker AM, Nguyen SN, Gonzalez-Perez MP, Ballif BA, Lechtreck KF, Witman GB, Pazour GJ. Hou Y, et al. PLoS Biol. 2025 Dec 12;23(12):e3003560. doi: 10.1371/journal.pbio.3003560. eCollection 2025 Dec. PLoS Biol. 2025. PMID: 41385589 Free PMC article.
The Chlamydomonas homolog of CDKL5, LF5, is a flagellar protein whose loss leads to elongated flagella. Here, we combine live-cell imaging, immunofluorescence, and biochemical approaches including mass spectrometry to define how CDKL5 activity is regulated an …
The Chlamydomonas homolog of CDKL5, LF5, is a flagellar protein whose loss leads to elongated flagella. Here, we combine live-cell im …
Regulation of protein kinase cascades by protein phosphatase 2A.
Millward TA, Zolnierowicz S, Hemmings BA. Millward TA, et al. Trends Biochem Sci. 1999 May;24(5):186-91. doi: 10.1016/s0968-0004(99)01375-4. Trends Biochem Sci. 1999. PMID: 10322434 Review.
Many protein kinases themselves are regulated by reversible phosphorylation. Upon cell stimulation, specific kinases are transiently phosphorylated and activated. Several of these protein kinases are substrates for protein p …
Many protein kinases themselves are regulated by reversible phosphorylation. Upon cell stimulation, specific kinases …
Regulation of the retinoblastoma tumor suppressor protein by cyclin/cdks.
Adams PD. Adams PD. Biochim Biophys Acta. 2001 Mar 21;1471(3):M123-33. doi: 10.1016/s0304-419x(01)00019-1. Biochim Biophys Acta. 2001. PMID: 11250068 Review.
The retinoblastoma tumor suppressor protein (pRB) is a paradigm for understanding cell cycle- and proliferation-dependent transcription and how deregulation of this process contributes to the neoplastic process in humans. The ability of pRB to regulate transcription …
The retinoblastoma tumor suppressor protein (pRB) is a paradigm for understanding cell cycle- and proliferation-dependent transcripti …
Regulation of yeast forkhead transcription factors and FoxM1 by cyclin-dependent and polo-like kinases.
Murakami H, Aiba H, Nakanishi M, Murakami-Tonami Y. Murakami H, et al. Cell Cycle. 2010 Aug 15;9(16):3233-42. doi: 10.4161/cc.9.16.12599. Epub 2010 Aug 2. Cell Cycle. 2010. PMID: 20716958 Review.
A subfamily of Fox proteins are required to activate expression of the genes encoding B-type cyclins, Cdc25 and Polo-like kinase (Plk) during the mitotic cell cycle and meiosis in organisms from yeast to mammals. These proteins are activators of cyclin …
A subfamily of Fox proteins are required to activate expression of the genes encoding B-type cyclins, Cdc25 and Polo-like kinase …
Regulation of cyclin-dependent kinase 2 activity by ceramide.
Lee JY, Bielawska AE, Obeid LM. Lee JY, et al. Exp Cell Res. 2000 Dec 15;261(2):303-11. doi: 10.1006/excr.2000.5028. Exp Cell Res. 2000. PMID: 11112337
Cyclin-dependent kinases have been implicated in the inactivation of retinoblastoma (Rb) protein and cell cycle progression. ...Using purified protein phosphatases, we showed that ceramide activated both protein phosphatase 1 and …
Cyclin-dependent kinases have been implicated in the inactivation of retinoblastoma (Rb) protein and cell cycle …
The Cyclin-dependent kinase 1: more than a cell cycle regulator.
Massacci G, Perfetto L, Sacco F. Massacci G, et al. Br J Cancer. 2023 Nov;129(11):1707-1716. doi: 10.1038/s41416-023-02468-8. Epub 2023 Oct 28. Br J Cancer. 2023. PMID: 37898722 Free PMC article. Review.
The Cyclin-dependent kinase 1, as a serine/threonine protein kinase, is more than a cell cycle regulator as it was originally identified. ...Here, we provide a comprehensive catalogue of the CDK1 upstream regulators a …
The Cyclin-dependent kinase 1, as a serine/threonine protein kinase, is more than a cell cy …
Fibronectin receptor modulates cyclin-dependent kinase activity.
Symington BE. Symington BE. J Biol Chem. 1992 Dec 25;267(36):25744-7. J Biol Chem. 1992. PMID: 1464591 Free article.
Expression of this integrin is altered by chemical and viral transformation, suggesting that FNR dysfunction may play a role in growth control. This study demonstrates that exposing FA-K562 cells to glycine-arginine-glycine-aspartate-serine (GRGDS), a peptide ligand …
Expression of this integrin is altered by chemical and viral transformation, suggesting that FNR dysfunction may play a role in growth co …
11,117 results
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