Liquid-Liquid Phase Separation-Mediated Cellular-Scale Compartmentalization of Hydrogel Covalent Cross-Linking Promotes Microtubule-Based Mechanosensing.
Zhao J, Hu Y, Li H, Liu C, Nie Z, Chen Z, Ling Q, Li Z, Zhao P, Song B, Zhang K, Bian L.
Zhao J, et al.
J Am Chem Soc. 2025 Apr 30;147(17):14336-14347. doi: 10.1021/jacs.5c00079. Epub 2025 Apr 19.
J Am Chem Soc. 2025.
PMID: 40252026
The obtained ECM-mimetic heterogeneous hydrogel, which is solely cross-linked by covalent bonds, promotes extensive spreading, microtubule-based mechanotransduction, and autophagic flux of encapsulated human mesenchymal stem cells (hMSCs), thereby enhancing osteogen …
The obtained ECM-mimetic heterogeneous hydrogel, which is solely cross-linked by covalent bonds, promotes extensive spreading, microtubul …