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Year Number of Results
1999 2
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192 results

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Page 1
Histone post-translational modifications - cause and consequence of genome function.
Millán-Zambrano G, Burton A, Bannister AJ, Schneider R. Millán-Zambrano G, et al. Nat Rev Genet. 2022 Sep;23(9):563-580. doi: 10.1038/s41576-022-00468-7. Epub 2022 Mar 25. Nat Rev Genet. 2022. PMID: 35338361 Review.
Much has been learned since the early 1960s about histone post-translational modifications (PTMs) and how they affect DNA-templated processes at the molecular level. This understanding has been bolstered in the past decade by the identification of new types of histo …
Much has been learned since the early 1960s about histone post-translational modifications (PTMs) and how they affect DNA-template …
Epigenetic regulation in the tumor microenvironment: molecular mechanisms and therapeutic targets.
Yang J, Xu J, Wang W, Zhang B, Yu X, Shi S. Yang J, et al. Signal Transduct Target Ther. 2023 May 22;8(1):210. doi: 10.1038/s41392-023-01480-x. Signal Transduct Target Ther. 2023. PMID: 37217462 Free PMC article. Review.
Over decades, researchers have focused on the epigenetic control of DNA-templated processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification, and noncoding RNAs modulate many biological processes that are crucial to the developme …
Over decades, researchers have focused on the epigenetic control of DNA-templated processes. Histone modification, DNA …
Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3.
Farrelly LA, Thompson RE, Zhao S, Lepack AE, Lyu Y, Bhanu NV, Zhang B, Loh YE, Ramakrishnan A, Vadodaria KC, Heard KJ, Erikson G, Nakadai T, Bastle RM, Lukasak BJ, Zebroski H 3rd, Alenina N, Bader M, Berton O, Roeder RG, Molina H, Gage FH, Shen L, Garcia BA, Li H, Muir TW, Maze I. Farrelly LA, et al. Nature. 2019 Mar;567(7749):535-539. doi: 10.1038/s41586-019-1024-7. Epub 2019 Mar 13. Nature. 2019. PMID: 30867594 Free PMC article.
Chemical modifications of histones can mediate diverse DNA-templated processes, including gene transcription(1-3). Here we provide evidence for a class of histone post-translational modification, serotonylation of glutamine, which occurs at position 5 (Q5ser) …
Chemical modifications of histones can mediate diverse DNA-templated processes, including gene transcription(1-3). Here …
USP3 promotes DNA damage response and chemotherapy resistance through stabilizing and deubiquitinating SMARCA5 in prostate cancer.
Li S, Xiong S, Li Z, Yang L, Yang H, Xiong J, Pan W, Guo J, Xu S, Fu B. Li S, et al. Cell Death Dis. 2024 Nov 5;15(11):790. doi: 10.1038/s41419-024-07117-3. Cell Death Dis. 2024. PMID: 39500888 Free PMC article.
The chromatin-remodeling enzyme SMARCA5 plays a key role in DNA-templated events including transcription, DNA replication, and DNA repair. Loss of function of the SMARCA5 can cause neurodevelopmental disorder and Williams syndrome. ...Clinically, USP3 was sig …
The chromatin-remodeling enzyme SMARCA5 plays a key role in DNA-templated events including transcription, DNA replicati …
Integration of transcription coregulator complexes with sequence-specific DNA-binding factor interactomes.
Velthuijs N, Meldal B, Geessinck Q, Porras P, Medvedeva Y, Zubritskiy A, Orchard S, Logie C. Velthuijs N, et al. Biochim Biophys Acta Gene Regul Mech. 2021 Oct;1864(10):194749. doi: 10.1016/j.bbagrm.2021.194749. Epub 2021 Aug 21. Biochim Biophys Acta Gene Regul Mech. 2021. PMID: 34425241 Free PMC article.
The domain of transcription regulation has been notoriously difficult to annotate in the Gene Ontology, partly because of the intricacies of gene regulation which involve molecular interactions with DNA as well as amongst protein complexes. The molecular func …
The domain of transcription regulation has been notoriously difficult to annotate in the Gene Ontology, partly because of the …
Photo-Cross-Linking To Delineate Epigenetic Interactome.
Zhang Z, Lin J, Liu Z, Tian G, Li XM, Jing Y, Li X, Li XD. Zhang Z, et al. J Am Chem Soc. 2022 Nov 23;144(46):20979-20997. doi: 10.1021/jacs.2c06135. Epub 2022 Nov 8. J Am Chem Soc. 2022. PMID: 36346429 Review.
Covalent modifications of DNA and histones are key cellular epigenetic marks to regulate gene functions. Most of these epigenetic marks are added or removed by corresponding enzymes known as writers and erasers, whose catalytic activities normally rely on the presence of c …
Covalent modifications of DNA and histones are key cellular epigenetic marks to regulate gene functions. Most of these epigenetic mar …
Local Chromatin Motion and Transcription.
Babokhov M, Hibino K, Itoh Y, Maeshima K. Babokhov M, et al. J Mol Biol. 2020 Feb 7;432(3):694-700. doi: 10.1016/j.jmb.2019.10.018. Epub 2019 Nov 2. J Mol Biol. 2020. PMID: 31689435 Review.
The highly dynamic nature of chromatin has become increasingly appreciated, particularly in DNA-templated processes including transcription, because this dynamic property ensures a degree of DNA accessibility, even in compacted chromatin. ...This new view on …
The highly dynamic nature of chromatin has become increasingly appreciated, particularly in DNA-templated processes including …
Nucleosomes at the Dawn of Eukaryotes.
Hocher A, Warnecke T. Hocher A, et al. Genome Biol Evol. 2024 Mar 2;16(3):evae029. doi: 10.1093/gbe/evae029. Genome Biol Evol. 2024. PMID: 38366053 Free PMC article. Review.
Genome regulation in eukaryotes revolves around the nucleosome, the fundamental building block of eukaryotic chromatin. ...Yet despite its exceptional conservation and central role in orchestrating transcription, repair, and other DNA-templated process …
Genome regulation in eukaryotes revolves around the nucleosome, the fundamental building block of eukaryotic chromatin. ...Yet despit …
Metabolic regulation of histone post-translational modifications.
Fan J, Krautkramer KA, Feldman JL, Denu JM. Fan J, et al. ACS Chem Biol. 2015 Jan 16;10(1):95-108. doi: 10.1021/cb500846u. ACS Chem Biol. 2015. PMID: 25562692 Free PMC article. Review.
Histone post-translational modifications regulate transcription and other DNA-templated functions. This process is dynamically regulated by specific modifying enzymes whose activities require metabolites that either serve as cosubstrates or act …
Histone post-translational modifications regulate transcription and other DNA-templated functions. This process …
Nucleosome Dynamics during Transcription Elongation.
Huynh MT, Yadav SP, Reese JC, Lee TH. Huynh MT, et al. ACS Chem Biol. 2020 Dec 18;15(12):3133-3142. doi: 10.1021/acschembio.0c00617. Epub 2020 Dec 2. ACS Chem Biol. 2020. PMID: 33263994 Free PMC article.
Dynamic interactions between DNA and histones in the nucleosome are the molecular basis of gene accessibility regulation that governs the kinetics of various DNA-templated processes such as transcription elongation by RNA Polymerase II (Pol II). ...The …
Dynamic interactions between DNA and histones in the nucleosome are the molecular basis of gene accessibility regulation that governs …
192 results