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1957 1
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1972 23
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1974 41
1975 65
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2002 422
2003 382
2004 361
2005 425
2006 439
2007 455
2008 429
2009 461
2010 476
2011 479
2012 507
2013 479
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16,827 results

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Page 1
Regulated eukaryotic DNA replication origin firing with purified proteins.
Yeeles JT, Deegan TD, Janska A, Early A, Diffley JF. Yeeles JT, et al. Nature. 2015 Mar 26;519(7544):431-5. doi: 10.1038/nature14285. Epub 2015 Mar 4. Nature. 2015. PMID: 25739503 Free PMC article.
Here we describe the reconstitution of budding yeast DNA replication initiation with 16 purified replication factors, made from 42 polypeptides. Origin-dependent initiation recapitulates regulation seen in vivo. ...Dbf4-dependent kinase (DDK) promotes repl …
Here we describe the reconstitution of budding yeast DNA replication initiation with 16 purified replication factors, made fro …
Origins of DNA replication.
Ekundayo B, Bleichert F. Ekundayo B, et al. PLoS Genet. 2019 Sep 12;15(9):e1008320. doi: 10.1371/journal.pgen.1008320. eCollection 2019 Sep. PLoS Genet. 2019. PMID: 31513569 Free PMC article. Review.
DNA synthesis of daughter strands starts at discrete sites, termed replication origins, and proceeds in a bidirectional manner until all genomic DNA is replicated. Despite the fundamental nature of these events, organisms have evolved surprisingly divergent strategies that …
DNA synthesis of daughter strands starts at discrete sites, termed replication origins, and proceeds in a bidirectional manner until …
Origins of DNA replication in eukaryotes.
Hu Y, Stillman B. Hu Y, et al. Mol Cell. 2023 Feb 2;83(3):352-372. doi: 10.1016/j.molcel.2022.12.024. Epub 2023 Jan 13. Mol Cell. 2023. PMID: 36640769 Free PMC article. Review.
Errors occurring during DNA replication can result in inaccurate replication, incomplete replication, or re-replication, resulting in genome instability that can lead to diseases such as cancer or disorders such as autism. A great deal of progress has …
Errors occurring during DNA replication can result in inaccurate replication, incomplete replication, or re-replicat …
Preventing excess replication origin activation to ensure genome stability.
Thakur BL, Ray A, Redon CE, Aladjem MI. Thakur BL, et al. Trends Genet. 2022 Feb;38(2):169-181. doi: 10.1016/j.tig.2021.09.008. Epub 2021 Oct 6. Trends Genet. 2022. PMID: 34625299 Free PMC article. Review.
The genomic instability that accompanies excess replication origin activation can provide a promising target for therapeutic intervention. Here we review molecular pathways that modulate replication origin dormancy, prevent excess origin activat …
The genomic instability that accompanies excess replication origin activation can provide a promising target for therapeutic i …
Mapping replication origin sequences in eukaryotic chromosomes.
Fu H, Besnard E, Desprat R, Ryan M, Kahli M, Lemaitre JM, Aladjem MI. Fu H, et al. Curr Protoc Cell Biol. 2014 Dec 1;65:22.20.1-17. doi: 10.1002/0471143030.cb2220s65. Curr Protoc Cell Biol. 2014. PMID: 25447077 Free PMC article. Review.
Recent advances in genome-sequencing technology have led to the complete mapping of DNA replication initiation sites in the human genome. This thorough origin mapping facilitates understanding of the relationship between replication initiation events, transcr …
Recent advances in genome-sequencing technology have led to the complete mapping of DNA replication initiation sites in the human gen …
Replication Origin Deletion Enhances Poly(3-Hydroxybutyrate-co-3-Hydroxyvalerate) Synthesis in Haloarchaea.
Yang H, Chen J, Mitra R, Xue Q, Xiang H, Han J. Yang H, et al. Microbiol Spectr. 2022 Dec 21;10(6):e0214922. doi: 10.1128/spectrum.02149-22. Epub 2022 Oct 20. Microbiol Spectr. 2022. PMID: 36264235 Free PMC article.
Although the use of multiple replication origins for chromosome replication has been widely characterized in haloarchaea, whether it is possible to manipulate the chromosome copy number by their genetic engineering is not known, and how it would affect the cell func …
Although the use of multiple replication origins for chromosome replication has been widely characterized in haloarchaea, whet …
Do Archaea Need an Origin of Replication?
Kelman LM, Kelman Z. Kelman LM, et al. Trends Microbiol. 2018 Mar;26(3):172-174. doi: 10.1016/j.tim.2017.12.001. Trends Microbiol. 2018. PMID: 29268981 Free PMC article. Review.
Chromosomal DNA replication starts at a specific region called an origin of replication. Until recently, all organisms were thought to require origins to replicate their chromosomes. It was recently discovered that some archaeal species do not utilize origins …
Chromosomal DNA replication starts at a specific region called an origin of replication. Until recently, all organisms …
DNA replication origin activation in space and time.
Fragkos M, Ganier O, Coulombe P, Méchali M. Fragkos M, et al. Nat Rev Mol Cell Biol. 2015 Jun;16(6):360-74. doi: 10.1038/nrm4002. Nat Rev Mol Cell Biol. 2015. PMID: 25999062 Review.
DNA replication begins with the assembly of pre-replication complexes (pre-RCs) at thousands of DNA replication origins during the G1 phase of the cell cycle. ...Recent insights into the mechanisms underlying this choice reveal how flexibility in origin …
DNA replication begins with the assembly of pre-replication complexes (pre-RCs) at thousands of DNA replication origins …
Assembly and activation of replicative helicases at origin DNA for replication initiation.
Zhang Q, Lam WH, Zhai Y. Zhang Q, et al. Curr Opin Struct Biol. 2024 Oct;88:102876. doi: 10.1016/j.sbi.2024.102876. Epub 2024 Jul 9. Curr Opin Struct Biol. 2024. PMID: 38986167 Review.
To initiate DNA replication, it is essential to properly assemble a pair of replicative helicases at each replication origin. ...This review primarily focuses on the latest structural discoveries that shed light on the key molecular machineries responsible fo …
To initiate DNA replication, it is essential to properly assemble a pair of replicative helicases at each replication origi …
Replication origin flexibility: a tool to mitigate the hazards of excess replication.
Fu H, Redon CE, Brenner HM, Ack MR, Aladjem MI. Fu H, et al. Trends Genet. 2026 Jun;42(6):510-523. doi: 10.1016/j.tig.2026.02.005. Epub 2026 Mar 19. Trends Genet. 2026. PMID: 41862351 Free PMC article. Review.
Recent studies reveal chromatin-dependent mechanisms preventing DNA synthesis at damaged nuclear compartments while permitting replication elsewhere. To minimize replication stress, cells activate signaling cascades with dual roles: blocking replication at do …
Recent studies reveal chromatin-dependent mechanisms preventing DNA synthesis at damaged nuclear compartments while permitting replicatio …
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