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Did you mean episome (156,172 results)?
Replisome passage through the cohesin ring.
Glaser S, Molodtsov MI, Diffley JFX, Uhlmann F. Glaser S, et al. Cell. 2025 Oct 2;188(20):5618-5631.e14. doi: 10.1016/j.cell.2025.08.028. Epub 2025 Sep 16. Cell. 2025. PMID: 40961938 Free article.
Following eukaryotic genome replication, the ring-shaped cohesin complex embraces the two newly synthesized sister chromatids, enabling their faithful segregation during cell divisions. Replisome passage through cohesin rings has been envisioned as a fail-safe mechanism th …
Following eukaryotic genome replication, the ring-shaped cohesin complex embraces the two newly synthesized sister chromatids, enabling thei …
An Orthogonal T7 Replisome for Continuous Hypermutation and Accelerated Evolution in E. coli.
Diercks CS, Sondermann PJ, Rong C, Dik DA, Gillis TG, Ban Y, Schultz PG. Diercks CS, et al. bioRxiv [Preprint]. 2024 Jul 26:2024.07.25.605042. doi: 10.1101/2024.07.25.605042. bioRxiv. 2024. Update in: Science. 2025 Aug 7;389(6760):618-622. doi: 10.1126/science.adp9583. PMID: 39211285 Free PMC article. Updated. Preprint.
We describe an orthogonal DNA replication system in E. coli based on the controlled expression of the replisome of bacteriophage T7. The system replicates circular plasmids that enable high transformation efficiencies and seamless integration into standard molecular biolog …
We describe an orthogonal DNA replication system in E. coli based on the controlled expression of the replisome of bacteriophage T7. …
Structure of a human replisome shows the organisation and interactions of a DNA replication machine.
Jones ML, Baris Y, Taylor MRG, Yeeles JTP. Jones ML, et al. EMBO J. 2021 Dec 1;40(23):e108819. doi: 10.15252/embj.2021108819. Epub 2021 Oct 25. EMBO J. 2021. PMID: 34694004 Free PMC article.
The human replisome is an elaborate arrangement of molecular machines responsible for accurate chromosome replication. ...We have determined a 3.2 A cryo-EM structure of a human replisome comprising CMG, Pol epsilon, TIMELESS-TIPIN, CLASPIN and AND-1 bound to replic …
The human replisome is an elaborate arrangement of molecular machines responsible for accurate chromosome replication. ...We have det …
Replisome-Cohesin Interfacing: A Molecular Perspective.
Villa-Hernández S, Bermejo R. Villa-Hernández S, et al. Bioessays. 2018 Oct;40(10):e1800109. doi: 10.1002/bies.201800109. Epub 2018 Aug 14. Bioessays. 2018. PMID: 30106480 Review.
Cohesion is established in S-phase through the action of key replisome factors as replication forks engage cohesin molecules. By holding sister chromatids together, cohesion critically assists both an equal segregation of the duplicated genetic material and an efficient re …
Cohesion is established in S-phase through the action of key replisome factors as replication forks engage cohesin molecules. By hold …
The replisome guides nucleosome assembly during DNA replication.
Zhang W, Feng J, Li Q. Zhang W, et al. Cell Biosci. 2020 Mar 12;10:37. doi: 10.1186/s13578-020-00398-z. eCollection 2020. Cell Biosci. 2020. PMID: 32190287 Free PMC article. Review.
This review discusses a set of recent findings regarding the role of replisome components contributing to RC nucleosome assembly. Starting with a brief introduction to the factors involved in nucleosome assembly and some aspects of the architecture of the eukaryotic rep …
This review discusses a set of recent findings regarding the role of replisome components contributing to RC nucleosome assembly. Sta …
An orthogonal T7 replisome for continuous hypermutation and accelerated evolution in E. coli.
Diercks CS, Sondermann P, Rong C, Gillis TG, Ban Y, Wang C, Dik DA, Schultz PG. Diercks CS, et al. Science. 2025 Aug 7;389(6760):618-622. doi: 10.1126/science.adp9583. Epub 2025 Aug 7. Science. 2025. PMID: 40773556
We describe an orthogonal DNA replication system in Escherichia coli based on the controlled expression of the replisome of bacteriophage T7 (T7-ORACLE). The system replicates circular plasmids that enable high transformation efficiencies and seamless integration into stan …
We describe an orthogonal DNA replication system in Escherichia coli based on the controlled expression of the replisome of bacteriop …
G-quadruplex-stalled eukaryotic replisome structure reveals helical inchworm DNA translocation.
Batra S, Allwein B, Kumar C, Devbhandari S, Brüning JG, Bahng S, Lee CM, Marians KJ, Hite RK, Remus D. Batra S, et al. Science. 2025 Mar 7;387(6738):eadt1978. doi: 10.1126/science.adt1978. Epub 2025 Mar 7. Science. 2025. PMID: 40048517 Free PMC article.
To elucidate how G4s induce replication fork arrest, we characterized fork collisions with preformed G4s in the parental DNA using reconstituted yeast and human replisomes. We demonstrate that a single G4 in the leading strand template is sufficient to stall replisomes …
To elucidate how G4s induce replication fork arrest, we characterized fork collisions with preformed G4s in the parental DNA using reconstit …
Mechanisms of eukaryotic replisome disassembly.
Moreno SP, Gambus A. Moreno SP, et al. Biochem Soc Trans. 2020 Jun 30;48(3):823-836. doi: 10.1042/BST20190363. Biochem Soc Trans. 2020. PMID: 32490508 Free PMC article. Review.
In the last six years however, researchers have also focused on deciphering the molecular mechanisms underlying the disassembly of the replicative helicase during termination. Similar to replisome assembly, the mechanism of replisome disassembly is strictly regulate …
In the last six years however, researchers have also focused on deciphering the molecular mechanisms underlying the disassembly of the repli …
A conserved mechanism for regulating replisome disassembly in eukaryotes.
Jenkyn-Bedford M, Jones ML, Baris Y, Labib KPM, Cannone G, Yeeles JTP, Deegan TD. Jenkyn-Bedford M, et al. Nature. 2021 Dec;600(7890):743-747. doi: 10.1038/s41586-021-04145-3. Epub 2021 Oct 26. Nature. 2021. PMID: 34700328 Free PMC article.
However, it is unknown how SCF(Dia2) and CUL2(LRR1) discriminate terminated from elongating replisomes, to selectively ubiquitylate CMG only after termination. Here we used cryo-electron microscopy to solve high-resolution structures of budding yeast and human replisome …
However, it is unknown how SCF(Dia2) and CUL2(LRR1) discriminate terminated from elongating replisomes, to selectively ubiquitylate C …
Replisome structure suggests mechanism for continuous fork progression and post-replication repair.
Yang W, Seidman MM, Rupp WD, Gao Y. Yang W, et al. DNA Repair (Amst). 2019 Sep;81:102658. doi: 10.1016/j.dnarep.2019.102658. Epub 2019 Jul 8. DNA Repair (Amst). 2019. PMID: 31303546 Free PMC article. Review.
The recently determined structure of the bacteriophage T7 replisome offers the first glimpse of how helicase, primase, leading-and lagging-strand DNA polymerases are organized around a DNA replication fork. The tightly coupled leading-strand polymerase and lagging-strand h …
The recently determined structure of the bacteriophage T7 replisome offers the first glimpse of how helicase, primase, leading-and la …
1,610 results