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1979 1
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4,875 results

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Page 1
Physiology and diseases of tissue-resident macrophages.
Lazarov T, Juarez-Carreño S, Cox N, Geissmann F. Lazarov T, et al. Nature. 2023 Jun;618(7966):698-707. doi: 10.1038/s41586-023-06002-x. Epub 2023 Jun 21. Nature. 2023. PMID: 37344646 Free PMC article. Review.
Embryo-derived tissue-resident macrophages are the first representatives of the haematopoietic lineage to emerge in metazoans. ...Resident macrophages are an integral part of tissues together with specialized cells: for instance, microglia reside with …
Embryo-derived tissue-resident macrophages are the first representatives of the haematopoietic lineage to emerge in metazoans. ... …
Microglia: Immune and non-immune functions.
Borst K, Dumas AA, Prinz M. Borst K, et al. Immunity. 2021 Oct 12;54(10):2194-2208. doi: 10.1016/j.immuni.2021.09.014. Immunity. 2021. PMID: 34644556 Free article. Review.
As resident macrophages of the central nervous system (CNS), microglia are associated with diverse functions essential to the developing and adult brain during homeostasis and disease. ...Harmonious cell-cell communication involving microglia are considered c …
As resident macrophages of the central nervous system (CNS), microglia are associated with diverse functions essential to the …
Microglia coordinate cellular interactions during spinal cord repair in mice.
Brennan FH, Li Y, Wang C, Ma A, Guo Q, Li Y, Pukos N, Campbell WA, Witcher KG, Guan Z, Kigerl KA, Hall JCE, Godbout JP, Fischer AJ, McTigue DM, He Z, Ma Q, Popovich PG. Brennan FH, et al. Nat Commun. 2022 Jul 14;13(1):4096. doi: 10.1038/s41467-022-31797-0. Nat Commun. 2022. PMID: 35835751 Free PMC article.
Traumatic spinal cord injury (SCI) triggers a neuro-inflammatory response dominated by tissue-resident microglia and monocyte derived macrophages (MDMs). Since activated microglia and MDMs are morphologically identical and express similar phenotypic markers i …
Traumatic spinal cord injury (SCI) triggers a neuro-inflammatory response dominated by tissue-resident microglia and monocyte …
An in vivo neuroimmune organoid model to study human microglia phenotypes.
Schafer ST, Mansour AA, Schlachetzki JCM, Pena M, Ghassemzadeh S, Mitchell L, Mar A, Quang D, Stumpf S, Ortiz IS, Lana AJ, Baek C, Zaghal R, Glass CK, Nimmerjahn A, Gage FH. Schafer ST, et al. Cell. 2023 May 11;186(10):2111-2126.e20. doi: 10.1016/j.cell.2023.04.022. Cell. 2023. PMID: 37172564 Free PMC article.
Microglia are specialized brain-resident macrophages that play crucial roles in brain development, homeostasis, and disease. ...Our data show that organoid-resident hMGs gain human-specific transcriptomic signatures that closely resemble their in vivo counter …
Microglia are specialized brain-resident macrophages that play crucial roles in brain development, homeostasis, and disease. . …
Distinct Features of Brain-Resident Macrophages: Microglia and Non-Parenchymal Brain Macrophages.
Lee E, Eo JC, Lee C, Yu JW. Lee E, et al. Mol Cells. 2021 May 31;44(5):281-291. doi: 10.14348/molcells.2021.0060. Mol Cells. 2021. PMID: 33972475 Free PMC article. Review.
Brain-resident macrophages can be classified into microglia in the brain parenchyma and non-parenchymal brain macrophages, also known as central nervous system-associated or border-associated macrophages, in the brain-circulation interface. ...In particular, diverse …
Brain-resident macrophages can be classified into microglia in the brain parenchyma and non-parenchymal brain macrophages, als …
Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition.
Pasciuto E, Burton OT, Roca CP, Lagou V, Rajan WD, Theys T, Mancuso R, Tito RY, Kouser L, Callaerts-Vegh Z, de la Fuente AG, Prezzemolo T, Mascali LG, Brajic A, Whyte CE, Yshii L, Martinez-Muriana A, Naughton M, Young A, Moudra A, Lemaitre P, Poovathingal S, Raes J, De Strooper B, Fitzgerald DC, Dooley J, Liston A. Pasciuto E, et al. Cell. 2020 Aug 6;182(3):625-640.e24. doi: 10.1016/j.cell.2020.06.026. Epub 2020 Jul 22. Cell. 2020. PMID: 32702313 Free PMC article.
We used a combination of imaging, single cell, and surgical approaches to identify a CD69(+) CD4 T cell population in both the mouse and human brain, distinct from circulating CD4 T cells. The brain-resident population was derived through in situ differentiation from activ …
We used a combination of imaging, single cell, and surgical approaches to identify a CD69(+) CD4 T cell population in both the mouse and hum …
Repair-associated macrophages increase after early-phase microglia attenuation to promote ischemic stroke recovery.
Zhang X, Li H, Gu Y, Ping A, Chen J, Zhang Q, Xu Z, Wang J, Tang S, Wang R, Lu J, Lu L, Jin C, Jin Z, Zhang J, Shi L. Zhang X, et al. Nat Commun. 2025 Mar 31;16(1):3089. doi: 10.1038/s41467-025-58254-y. Nat Commun. 2025. PMID: 40164598 Free PMC article.
Ischemic stroke recovery involves dynamic interactions between the central nervous system and infiltrating immune cells. Peripheral immune cells compete with resident microglia for spatial niches in the brain, but how modulating this balance affects recovery remains …
Ischemic stroke recovery involves dynamic interactions between the central nervous system and infiltrating immune cells. Peripheral immune c …
Neuroinflammation, Microglia and Implications for Retinal Ganglion Cell Survival and Axon Regeneration in Traumatic Optic Neuropathy.
Au NPB, Ma CHE. Au NPB, et al. Front Immunol. 2022 Mar 4;13:860070. doi: 10.3389/fimmu.2022.860070. eCollection 2022. Front Immunol. 2022. PMID: 35309305 Free PMC article. Review.
In this Review, we summarize the current understanding of resident retinal microglia in RGC survival and axon regeneration after ONC. Resident retinal microglia play a key role in facilitating Wallerian degeneration and the subsequent axon regeneration …
In this Review, we summarize the current understanding of resident retinal microglia in RGC survival and axon regeneration aft …
Impact of Microglia-Derived Extracellular Vesicles on Resident Central Nervous System Cell Populations After Acute Brain Injury Under Various External Stimuli Conditions.
Gong J, Li J, Li J, He A, Ren B, Zhao M, Li K, Zhang Y, He M, Liu Y, Wang Z. Gong J, et al. Mol Neurobiol. 2025 Aug;62(8):9586-9603. doi: 10.1007/s12035-025-04858-w. Epub 2025 Mar 24. Mol Neurobiol. 2025. PMID: 40126599 Free PMC article. Review.
Microglia, as innate immune cells of the CNS, respond to changes in the internal environment by altering their phenotype and secreting EVs that impact various CNS cells, including neurons, astrocytes, oligodendrocytes, endothelial cells, neural stem cells (NSCs), and mi …
Microglia, as innate immune cells of the CNS, respond to changes in the internal environment by altering their phenotype and secretin …
Single-cell transcriptomics reveals distinct inflammation-induced microglia signatures.
Sousa C, Golebiewska A, Poovathingal SK, Kaoma T, Pires-Afonso Y, Martina S, Coowar D, Azuaje F, Skupin A, Balling R, Biber K, Niclou SP, Michelucci A. Sousa C, et al. EMBO Rep. 2018 Nov;19(11):e46171. doi: 10.15252/embr.201846171. Epub 2018 Sep 11. EMBO Rep. 2018. PMID: 30206190 Free PMC article.
Microglia are specialized parenchymal-resident phagocytes of the central nervous system (CNS) that actively support, defend and modulate the neural environment. ...Here, using a combination of single-cell RNA sequencing and multicolour flow cytometry, we comprehensi …
Microglia are specialized parenchymal-resident phagocytes of the central nervous system (CNS) that actively support, defend an …
4,875 results