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Year Number of Results
2001 2
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14 results

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Page 1
Single-cell RNA sequencing data locate ALDH1A2-mediated retinoic acid synthetic pathway to glomerular parietal epithelial cells.
Liu WB, Fermin D, Xu AL, Kopp JB, Xu Q. Liu WB, et al. Exp Biol Med (Maywood). 2024 Sep 18;249:10167. doi: 10.3389/ebm.2024.10167. eCollection 2024. Exp Biol Med (Maywood). 2024. PMID: 39360029 Free PMC article. Review.
Our data mining and analyses led us to hypothesize that ALDH1A2-mediated retinoic acid synthesis in PECs plays a yet-undefined role in the kidney and that its dysregulation mediates injury. ...Clinical studies on genetics, epigenetics, expression and functions of ALDH1A2 a …
Our data mining and analyses led us to hypothesize that ALDH1A2-mediated retinoic acid synthesis in PECs plays a yet-undefined role i …
Collecting duct cells show differential retinoic acid responses to acute versus chronic kidney injury stimuli.
Papadimitriou A, Romagnani P, Angelotti ML, Noor M, Corcoran J, Raby K, Wilson PD, Li J, Fraser D, Piedagnel R, Hendry BM, Xu Q. Papadimitriou A, et al. Sci Rep. 2020 Oct 7;10(1):16683. doi: 10.1038/s41598-020-73099-9. Sci Rep. 2020. PMID: 33028882 Free PMC article.
Retinoic acid (RA) activates RA receptors (RAR), resulting in RA response element (RARE)-dependent gene expression in renal collecting duct (CD). ...
Retinoic acid (RA) activates RA receptors (RAR), resulting in RA response element (RARE)-dependent gene expression in renal collectin …
Cell Identity Switching Regulated by Retinoic Acid Signaling Maintains Homogeneous Segments in the Hindbrain.
Addison M, Xu Q, Cayuso J, Wilkinson DG. Addison M, et al. Dev Cell. 2018 Jun 4;45(5):606-620.e3. doi: 10.1016/j.devcel.2018.04.003. Epub 2018 May 3. Dev Cell. 2018. PMID: 29731343 Free PMC article.
We show that switching occurs during normal development and is mediated by feedback between segment identity and the retinoic acid degrading enzymes, cyp26b1 and cyp26c1. egr2, which specifies the segmental identity of rhombomeres r3 and r5, underlies the lower expression …
We show that switching occurs during normal development and is mediated by feedback between segment identity and the retinoic acid de …
An in vitro model for the pro-fibrotic effects of retinoids: mechanisms of action.
Rankin AC, Hendry BM, Corcoran JP, Xu Q. Rankin AC, et al. Br J Pharmacol. 2013 Nov;170(6):1177-89. doi: 10.1111/bph.12348. Br J Pharmacol. 2013. PMID: 23992207 Free PMC article.
BACKGROUND AND PURPOSE: Retinoids, including all-trans retinoic acid (tRA), have dose-dependent pro-fibrotic effects in experimental kidney diseases. ...EXPERIMENTAL APPROACH: Fibrogenic effects of retinoids were assessed in NRK-49F renal fibroblasts using pi …
BACKGROUND AND PURPOSE: Retinoids, including all-trans retinoic acid (tRA), have dose-dependent pro-fibrotic effects in experi …
Retinoic acid receptor-dependent, cell-autonomous, endogenous retinoic acid signaling and its target genes in mouse collecting duct cells.
Wong YF, Wilson PD, Unwin RJ, Norman JT, Arno M, Hendry BM, Xu Q. Wong YF, et al. PLoS One. 2012;7(9):e45725. doi: 10.1371/journal.pone.0045725. Epub 2012 Sep 26. PLoS One. 2012. PMID: 23049847 Free PMC article.
Most functions of vitamin A are mediated by its main active form, all-trans retinoic acid (tRA), which binds retinoic acid receptors (RARs) to modulate gene expression. ...
Most functions of vitamin A are mediated by its main active form, all-trans retinoic acid (tRA), which binds retinoic acid rec …
Retinoid and TGF-beta families: crosstalk in development, neoplasia, immunity, and tissue repair.
Xu Q, Kopp JB. Xu Q, et al. Semin Nephrol. 2012 May;32(3):287-94. doi: 10.1016/j.semnephrol.2012.04.008. Semin Nephrol. 2012. PMID: 22835460 Free PMC article. Review.
Transforming growth factor-beta (TGF-beta) isoforms are profibrotic cytokines, par excellence, and have complex multifunctional effects on many systems, depending on the biologic setting. Retinoids are vitamin A derivatives that also have diverse effects in development, ph …
Transforming growth factor-beta (TGF-beta) isoforms are profibrotic cytokines, par excellence, and have complex multifunctional effects on m …
Endogenous retinoic acid activity in principal cells and intercalated cells of mouse collecting duct system.
Wong YF, Kopp JB, Roberts C, Scambler PJ, Abe Y, Rankin AC, Dutt N, Hendry BM, Xu Q. Wong YF, et al. PLoS One. 2011 Feb 4;6(2):e16770. doi: 10.1371/journal.pone.0016770. PLoS One. 2011. PMID: 21326615 Free PMC article.
BACKGROUND: Retinoic acid is the bioactive derivative of vitamin A, which plays an indispensible role in kidney development by activating retinoic acid receptors. ...Double immunostaining was performed for beta-galactosidase and markers of kidney tubules to localize …
BACKGROUND: Retinoic acid is the bioactive derivative of vitamin A, which plays an indispensible role in kidney development by activa …
Kidneys of Alb/TGF-beta1 transgenic mice are deficient in retinoic acid and exogenous retinoic acid shows dose-dependent toxicity.
Xu Q, Hendry BM, Maden M, Lu H, Wong YF, Rankin AC, Noor M, Kopp JB. Xu Q, et al. Nephron Exp Nephrol. 2010;114(4):e127-32. doi: 10.1159/000276587. Epub 2010 Jan 21. Nephron Exp Nephrol. 2010. PMID: 20110732 Free PMC article.
This study was designed to explore if exogenous all-trans retinoic acid (tRA) prevents renal fibrosis in this animal model. METHODS: The retinoid profile in kidney and liver of wild-type and Alb/TGF-beta(1) transgenic mice was examined by high-performance liquid chr …
This study was designed to explore if exogenous all-trans retinoic acid (tRA) prevents renal fibrosis in this animal model. METHODS: …
Retinoids in nephrology: promises and pitfalls.
Xu Q, Lucio-Cazana J, Kitamura M, Ruan X, Fine LG, Norman JT. Xu Q, et al. Kidney Int. 2004 Dec;66(6):2119-31. doi: 10.1111/j.1523-1755.2004.66002.x. Kidney Int. 2004. PMID: 15569301 Free article. Review.
METHODS: The biological importance of retinoids in the kidney and the potential of retinoids in the treatment of renal diseases are reviewed. ...In animal studies, the adverse effects of retinoids are generally minimal; however, the clinical use of retinoi …
METHODS: The biological importance of retinoids in the kidney and the potential of retinoids in the treatment of renal disease …
14 results