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Page 1
Retinoic acid signaling pathways.
Ghyselinck NB, Duester G. Ghyselinck NB, et al. Development. 2019 Jul 4;146(13):dev167502. doi: 10.1242/dev.167502. Development. 2019. PMID: 31273085 Free PMC article. Review.
Retinoic acid (RA), a metabolite of retinol (vitamin A), functions as a ligand for nuclear RA receptors (RARs) that regulate development of chordate animals. ...
Retinoic acid (RA), a metabolite of retinol (vitamin A), functions as a ligand for nuclear RA receptors (RARs) that regulate d …
Retinoic Acid and Its Derivatives in Skin.
Szymański Ł, Skopek R, Palusińska M, Schenk T, Stengel S, Lewicki S, Kraj L, Kamiński P, Zelent A. Szymański Ł, et al. Cells. 2020 Dec 11;9(12):2660. doi: 10.3390/cells9122660. Cells. 2020. PMID: 33322246 Free PMC article. Review.
ATRA and other retinoids have also been successfully applied in a variety of dermatological conditions such as skin cancer, psoriasis, acne, and ichthyosis. Moreover, modulation of retinoic acid receptors and retinoid X (or rexinoid) receptors function may affect de …
ATRA and other retinoids have also been successfully applied in a variety of dermatological conditions such as skin cancer, psoriasis, acne, …
Gene expression regulation by retinoic acid.
Balmer JE, Blomhoff R. Balmer JE, et al. J Lipid Res. 2002 Nov;43(11):1773-808. doi: 10.1194/jlr.r100015-jlr200. J Lipid Res. 2002. PMID: 12401878 Free article. Review.
Over the last quarter century, more than 532 genes have been put forward as regulatory targets of retinoic acid. In some cases this control is direct, driven by a liganded heterodimer of retinoid receptors bound to a DNA response element; in others, it is indirect, …
Over the last quarter century, more than 532 genes have been put forward as regulatory targets of retinoic acid. In some cases …
Overview of all-trans-retinoic acid (ATRA) and its analogues: Structures, activities, and mechanisms in acute promyelocytic leukaemia.
Liang C, Qiao G, Liu Y, Tian L, Hui N, Li J, Ma Y, Li H, Zhao Q, Cao W, Liu H, Ren X. Liang C, et al. Eur J Med Chem. 2021 Aug 5;220:113451. doi: 10.1016/j.ejmech.2021.113451. Epub 2021 Apr 15. Eur J Med Chem. 2021. PMID: 33895500 Review.
All-trans-retinoic acid (ATRA) is effective for preventing cancer and treating skin diseases and acute promyelocytic leukaemia (APL). These pharmacological effects of ATRA are mainly mediated by retinoid X receptors (RXRs) and retinoic acid receptors ( …
All-trans-retinoic acid (ATRA) is effective for preventing cancer and treating skin diseases and acute promyelocytic leukaemia …
Retinoic Acid and Retinoid X Receptors.
Schubert M, Germain P. Schubert M, et al. Cells. 2023 Mar 10;12(6):864. doi: 10.3390/cells12060864. Cells. 2023. PMID: 36980205 Free PMC article.
Effect of retinoic acid on the neurovascular unit: A review.
Pouso MR, Cairrao E. Pouso MR, et al. Brain Res Bull. 2022 Jun 15;184:34-45. doi: 10.1016/j.brainresbull.2022.03.011. Epub 2022 Mar 26. Brain Res Bull. 2022. PMID: 35351589 Free article. Review.
Retinoic acid is a metabolic product derived from vitamin A, acting at a nuclear level to maintain the proper transcriptional activity. ...Through this description, it seems apparent that retinoic acid administration might be an essential pharmacologic …
Retinoic acid is a metabolic product derived from vitamin A, acting at a nuclear level to maintain the proper transcriptional …
Retinoic Acid: Sexually Dimorphic, Anti-Insulin and Concentration-Dependent Effects on Energy.
Napoli JL. Napoli JL. Nutrients. 2022 Apr 8;14(8):1553. doi: 10.3390/nu14081553. Nutrients. 2022. PMID: 35458115 Free PMC article. Review.
This review addresses the fasting vs. re-feeding effects of retinoic acid (RA) biosynthesis and functions, and sexually dimorphic RA actions. It also discusses other understudied topics essential for understanding RA activities-especially interactions with energy-ba …
This review addresses the fasting vs. re-feeding effects of retinoic acid (RA) biosynthesis and functions, and sexually dimorp …
Generation of Retinaldehyde for Retinoic Acid Biosynthesis.
Belyaeva OV, Adams MK, Popov KM, Kedishvili NY. Belyaeva OV, et al. Biomolecules. 2019 Dec 18;10(1):5. doi: 10.3390/biom10010005. Biomolecules. 2019. PMID: 31861321 Free PMC article. Review.
Either too little or too much of retinoic acid in developing or adult tissues is equally harmful. All-trans-retinoic acid is produced by the irreversible oxidation of all-trans-retinaldehyde. Thus, the concentration of retinaldehyde as the immediate pr …
Either too little or too much of retinoic acid in developing or adult tissues is equally harmful. All-trans-retinoic …
Retinoic acid for treatment of systemic sclerosis and morphea: A literature review.
Thomas RM, Worswick S, Aleshin M. Thomas RM, et al. Dermatol Ther. 2017 Mar;30(2). doi: 10.1111/dth.12455. Epub 2016 Dec 29. Dermatol Ther. 2017. PMID: 28032675 Review.
Research elucidating the mechanism of action of retinoic acid on collagen production in the skin and case series highlighting the success of retinoic acid on the skin manifestations of systemic sclerosis and on morphea demonstrate its promise as a trea …
Research elucidating the mechanism of action of retinoic acid on collagen production in the skin and case series highlighting …
Retinoic acid signaling in development and differentiation commitment and its regulatory topology.
Wu D, Khan FA, Zhang K, Pandupuspitasari NS, Negara W, Guan K, Sun F, Huang C. Wu D, et al. Chem Biol Interact. 2024 Jan 5;387:110773. doi: 10.1016/j.cbi.2023.110773. Epub 2023 Nov 17. Chem Biol Interact. 2024. PMID: 37977248 Review.
Retinoic acid (RA), the derivative of vitamin A/retinol, is a signaling molecule with important implications in health and disease. ...
Retinoic acid (RA), the derivative of vitamin A/retinol, is a signaling molecule with important implications in health and dis …
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