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Page 1
Retrorsine.
[No authors listed] [No authors listed] IARC Monogr Eval Carcinog Risk Chem Man. 1976;10:303-12. IARC Monogr Eval Carcinog Risk Chem Man. 1976. PMID: 791803 Review. No abstract available.
Retrorsine impairs liver regeneration by inducing progenitor cell-senescence via ROS after partial hepatectomy.
Cui Y, Li L, He Y, Shan S, Liu L, Ren J, Wang H, Yang M, Zhao X, Jia J, Wang P. Cui Y, et al. Ann Med. 2026 Dec;58(1):2635821. doi: 10.1080/07853890.2026.2635821. Epub 2026 Mar 3. Ann Med. 2026. PMID: 41777124 Free PMC article.
The aim of this study is to reveal the regeneration contribution of HPCs after PH when hepatocyte proliferation is totally suppressed. METHODS: Retrorsine (RTS) was administered to suppress hepatocyte proliferation in C57BL/6J mice after PH. ...
The aim of this study is to reveal the regeneration contribution of HPCs after PH when hepatocyte proliferation is totally suppressed. METHO …
Lactational retrorsine exposure changes maternal milk components and disturbs metabolism homeostasis of offspring rats.
Dai Y, Guo Q, Xu K, Gong Z, Qiu S, Sun X, Liu J, Wang Y, Yang Z, Wang H, Guo Y. Dai Y, et al. Sci Total Environ. 2023 Oct 10;894:164929. doi: 10.1016/j.scitotenv.2023.164929. Epub 2023 Jun 15. Sci Total Environ. 2023. PMID: 37329908
In this study, we aimed to investigate the effect of lactational retrorsine (RTS, a typical toxic PA) exposure on breastmilk components and glucose-lipid metabolism of offspring rats. ...
In this study, we aimed to investigate the effect of lactational retrorsine (RTS, a typical toxic PA) exposure on breastmilk componen …
PBTK modeling of the pyrrolizidine alkaloid retrorsine to predict liver toxicity in mouse and rat.
Lehmann A, Geburek I, These A, Hessel-Pras S, Hengstler JG, Albrecht W, Mielke H, Müller-Graf C, Yang X, Kloft C, Hethey C. Lehmann A, et al. Arch Toxicol. 2023 May;97(5):1319-1333. doi: 10.1007/s00204-023-03453-z. Epub 2023 Mar 11. Arch Toxicol. 2023. PMID: 36906727 Free PMC article.
Retrorsine is a hepatotoxic pyrrolizidine alkaloid (PA) found in herbal supplements and medicines, food and livestock feed. ...PBTK model evaluation showed convincing goodness-of-fit for hepatic retrorsine and retrorsine-derived DNA adducts. Furthermore, the
Retrorsine is a hepatotoxic pyrrolizidine alkaloid (PA) found in herbal supplements and medicines, food and livestock feed. ...PBTK m
Retrorsine Cooperates with Gut Microbiota to Promote Hepatic Sinusoidal Obstruction Syndrome by Disrupting the Gut Barrier.
Xiao L, Hu L, Chu H, Chen L, Yan J, Wang W, Yang X, Zhu Q, Du F, Song Y, Chen P, Hou X, Yang L. Xiao L, et al. J Clin Transl Hepatol. 2022 Dec 28;10(6):1086-1098. doi: 10.14218/JCTH.2021.00398. Epub 2022 Mar 11. J Clin Transl Hepatol. 2022. PMID: 36381109 Free PMC article.
BACKGROUND AND AIMS: Hepatic sinusoidal obstruction syndrome (HSOS) is a life-threatening syndrome, and a cause is exposure to pyrrolizidine alkaloid (PA)-containing products. It is well-established that retrorsine (RTS), a representative Pas, insults hepatic sinusoidal en …
BACKGROUND AND AIMS: Hepatic sinusoidal obstruction syndrome (HSOS) is a life-threatening syndrome, and a cause is exposure to pyrrolizidine …
Repair of Retrorsine-Induced DNA Damage in Rat Livers: Insights Gained from Transcriptomic and Proteomic Studies.
Long Y, Wang Y, Song Z, He X, He Y, Lin G. Long Y, et al. Toxins (Basel). 2024 Dec 13;16(12):538. doi: 10.3390/toxins16120538. Toxins (Basel). 2024. PMID: 39728796 Free PMC article.
In the present study, Sprague Dawley (SD) rats were exposed to retrorsine (RTS), a representative PA, at a human-relevant dose of 3.3 mg/kg/day for 28 days. ...
In the present study, Sprague Dawley (SD) rats were exposed to retrorsine (RTS), a representative PA, at a human-relevant dose of 3.3 …
CYP2C and CYP2B Mediated Metabolic Activation of Retrorsine in Cyp3a Knockout Mice.
Pang X, Tang C, Kong F, Chen M, Chen X. Pang X, et al. Curr Drug Metab. 2020;21(13):1040-1051. doi: 10.2174/1389200221666201202101715. Curr Drug Metab. 2020. PMID: 33267758
BACKGROUND: Retrorsine is one of the hepatotoxic pyrrolizidine alkaloids, which could be converted into a highly reactive metabolite, dehydroretrorsine, by CYP3A, and to a lesser extent by CYP2C and CYP2B. ...The increased serum IL6 might mediate the retrorsine-indu …
BACKGROUND: Retrorsine is one of the hepatotoxic pyrrolizidine alkaloids, which could be converted into a highly reactive metabolite, …
Metabolic Activation of Retrorsine may Disrupt Bile Acid Homeostasis in Mice through the Nrf2 Pathway.
Pang X, Tang C, Cao P, Zhou L, Chen X. Pang X, et al. Curr Drug Metab. 2021;22(11):870-881. doi: 10.2174/1389200222666210427124332. Curr Drug Metab. 2021. PMID: 33906588
RESULTS: The BA concentrations in serum were increased in the retrorsine-treated WT mice, along with the upregulation of BA transporters, Ostbeta, Mrp3, Mrp4, and Mrp2. ...In Nrf2 KO mice receiving retrorsine, the bile acids and the mRNA and protein levels of Mrp2, …
RESULTS: The BA concentrations in serum were increased in the retrorsine-treated WT mice, along with the upregulation of BA transport …
Toxicokinetic and bioavailability studies on retrorsine in mice, and ketoconazole-induced alteration in toxicokinetic properties.
Li J, Zhou M, Lai X, Wang Y, Zou Y, Li K, Li W, Zheng J. Li J, et al. Biomed Chromatogr. 2022 Feb;36(2):e5270. doi: 10.1002/bmc.5270. Epub 2021 Nov 22. Biomed Chromatogr. 2022. PMID: 34727371
Retrorsine (RTS) is a toxic retronecine-type pyrrolizidine alkaloid, which is widely distributed. ...
Retrorsine (RTS) is a toxic retronecine-type pyrrolizidine alkaloid, which is widely distributed. ...
Maternal-Fetal Disposition and Metabolism of Retrorsine in Pregnant Rats.
Li X, Yang X, Xiang E, Luo J, Qiu S, Fang Y, Zhang L, Guo Y, Zheng J, Wang H. Li X, et al. Drug Metab Dispos. 2018 Apr;46(4):422-428. doi: 10.1124/dmd.117.079186. Epub 2018 Jan 19. Drug Metab Dispos. 2018. PMID: 29352068
In this study, we determined the basal metabolic activation of retrorsine (RTS) in rat maternal liver, placenta, and fetal liver in vitro and examined the fetal toxicity and bioactivation of RTS in vivo. ...
In this study, we determined the basal metabolic activation of retrorsine (RTS) in rat maternal liver, placenta, and fetal liver in v …
331 results