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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1924 1
1940 1
1969 2
1975 1
1976 1
1980 1
1984 1
1987 3
1988 1
1995 1
1998 1
1999 2
2000 4
2001 2
2003 2
2004 3
2005 5
2006 4
2007 4
2008 8
2009 11
2010 21
2011 25
2012 22
2013 43
2014 44
2015 64
2016 42
2017 44
2018 48
2019 44
2020 36
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431 results
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Page 1
Warburg effect or reverse Warburg effect? A review of cancer metabolism.
Xu XD, Shao SX, Jiang HP, Cao YW, Wang YH, Yang XC, Wang YL, Wang XS, Niu HT. Xu XD, et al. Oncol Res Treat. 2015;38(3):117-22. doi: 10.1159/000375435. Epub 2015 Feb 19. Oncol Res Treat. 2015. PMID: 25792083 Review.
In the 1920s, Warburg found that cancer cells prefer to produce adenosine triphosphate (ATP) by glycolysis, which is a less efficient pathway compared to oxidative phosphorylation. ...Some studies have now shown contradicting evidence and a new hypothesis, the reverse
In the 1920s, Warburg found that cancer cells prefer to produce adenosine triphosphate (ATP) by glycolysis, which is a less efficient …
The reverse Warburg effect is likely to be an Achilles' heel of cancer that can be exploited for cancer therapy.
Fu Y, Liu S, Yin S, Niu W, Xiong W, Tan M, Li G, Zhou M. Fu Y, et al. Oncotarget. 2017 May 25;8(34):57813-57825. doi: 10.18632/oncotarget.18175. eCollection 2017 Aug 22. Oncotarget. 2017. PMID: 28915713 Free PMC article. Review.
In 2009, a novel 'two-compartment metabolic coupling' model, also named 'the reverse Warburg effect', was proposed and attracted lots of attention. ...Our review focuses on the paradigm shift from 'the Warburg effect' to 'the reverse Warburg eff …
In 2009, a novel 'two-compartment metabolic coupling' model, also named 'the reverse Warburg effect', was proposed and attract …
Metabolic coupling and the Reverse Warburg Effect in cancer: Implications for novel biomarker and anticancer agent development.
Wilde L, Roche M, Domingo-Vidal M, Tanson K, Philp N, Curry J, Martinez-Outschoorn U. Wilde L, et al. Semin Oncol. 2017 Jun;44(3):198-203. doi: 10.1053/j.seminoncol.2017.10.004. Epub 2017 Oct 10. Semin Oncol. 2017. PMID: 29248131 Free PMC article. Review.
The Reverse Warburg Effect describes when glycolysis in the cancer-associated stroma metabolically supports adjacent cancer cells. ...
The Reverse Warburg Effect describes when glycolysis in the cancer-associated stroma metabolically supports adjacent cancer ce …
The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma.
Pavlides S, Whitaker-Menezes D, Castello-Cros R, Flomenberg N, Witkiewicz AK, Frank PG, Casimiro MC, Wang C, Fortina P, Addya S, Pestell RG, Martinez-Outschoorn UE, Sotgia F, Lisanti MP. Pavlides S, et al. Cell Cycle. 2009 Dec;8(23):3984-4001. doi: 10.4161/cc.8.23.10238. Epub 2009 Dec 5. Cell Cycle. 2009. PMID: 19923890
This alternative model is still consistent with Warburg's original observation that tumors show a metabolic shift towards aerobic glycolysis. ...Thus, an absence of stromal Cav-1 may be a biomarker for the "Reverse Warburg Effect," explaining its power …
This alternative model is still consistent with Warburg's original observation that tumors show a metabolic shift towards aero …
Overcoming the Warburg Effect: Is it the key to survival in sepsis?
Bar-Or D, Carrick M, Tanner A 2nd, Lieser MJ, Rael LT, Brody E. Bar-Or D, et al. J Crit Care. 2018 Feb;43:197-201. doi: 10.1016/j.jcrc.2017.09.012. Epub 2017 Sep 8. J Crit Care. 2018. PMID: 28915394 Review.
This review provides some evidence that reversing these steps reverses the Warburg Effect in model systems and some pathological consequences of this effect. Therefore, this implies that these steps might be modifiable in sepsis to reverse the Warbu
This review provides some evidence that reversing these steps reverses the Warburg Effect in model systems and some pat …
Autophagy, Warburg, and Warburg reverse effects in human cancer.
Gonzalez CD, Alvarez S, Ropolo A, Rosenzvit C, Bagnes MF, Vaccaro MI. Gonzalez CD, et al. Biomed Res Int. 2014;2014:926729. doi: 10.1155/2014/926729. Epub 2014 Aug 12. Biomed Res Int. 2014. PMID: 25197670 Free PMC article. Review.
These series of observations drove to the proposal of a putative reverse Warburg effect of pathophysiological relevance for, at least, some tumor phenotypes. ...We define and describe the Warburg effect and the newly suggested "reverse" hypothesis. We …
These series of observations drove to the proposal of a putative reverse Warburg effect of pathophysiological relevance for, a …
The Warburg metabolism fuels tumor metastasis.
Lu J. Lu J. Cancer Metastasis Rev. 2019 Jun;38(1-2):157-164. doi: 10.1007/s10555-019-09794-5. Cancer Metastasis Rev. 2019. PMID: 30997670 Review.
While promoting oxidative metabolism and reversing the Warburg effect, PGC1α critically activates antioxidant genes and protects cells against oxidative damage. ...Synthetic lethal combination therapies are thus essential to attack the liabilities of the Warburg
While promoting oxidative metabolism and reversing the Warburg effect, PGC1α critically activates antioxidant genes and protec …
The reverse Warburg effect in osteosarcoma.
Sotgia F, Martinez-Outschoorn UE, Lisanti MP. Sotgia F, et al. Oncotarget. 2014 Sep 30;5(18):7982-3. doi: 10.18632/oncotarget.2352. Oncotarget. 2014. PMID: 25478627 Free PMC article. No abstract available.
Multi-scale computational study of the Warburg effect, reverse Warburg effect and glutamine addiction in solid tumors.
Shan M, Dai D, Vudem A, Varner JD, Stroock AD. Shan M, et al. PLoS Comput Biol. 2018 Dec 7;14(12):e1006584. doi: 10.1371/journal.pcbi.1006584. eCollection 2018 Dec. PLoS Comput Biol. 2018. PMID: 30532226 Free PMC article.
In this study, we use a multi-scale modeling approach to interrogate the implications of three metabolic scenarios of potential clinical relevance: the Warburg effect, the reverse Warburg effect and glutamine addiction. ...On the other hand, the reverse
In this study, we use a multi-scale modeling approach to interrogate the implications of three metabolic scenarios of potential clinical rel …
PGC1α promotes cholangiocarcinoma metastasis by upregulating PDHA1 and MPC1 expression to reverse the Warburg effect.
Dan Li, Wang C, Ma P, Yu Q, Gu M, Dong L, Jiang W, Pan S, Xie C, Han J, Lan Y, Sun J, Sheng P, Liu K, Wu Y, Liu L, Ma Y, Jiang H. Dan Li, et al. Cell Death Dis. 2018 May 1;9(5):466. doi: 10.1038/s41419-018-0494-0. Cell Death Dis. 2018. PMID: 29700317 Free PMC article.
Mechanistically, for the first time, we illuminated that PGC1α reversed the Warburg effect by upregulating the expression of pyruvate dehydrogenase E1 alpha 1 subunit and mitochondrial pyruvate carrier 1 to increase pyruvate flux into the mitochondria for oxidation, …
Mechanistically, for the first time, we illuminated that PGC1α reversed the Warburg effect by upregulating the expression of p …
431 results
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