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Rhodiola and salidroside in the treatment of metabolic disorders.
Bai XL, Deng XL, Wu GJ, Li WJ, Jin S. Bai XL, et al. Mini Rev Med Chem. 2019;19(19):1611-1626. doi: 10.2174/1389557519666190903115424. Mini Rev Med Chem. 2019. PMID: 31481002 Review.
Extracts of Rhodiola and salidroside, the most abundant active compound in Rhodiola, are suggested to provide a beneficial effect in mental, behavioral, and metabolic disorders. ...This review highlights studies that focus on the potential role of Rhodiola ex …
Extracts of Rhodiola and salidroside, the most abundant active compound in Rhodiola, are suggested to provide a beneficial eff …
Salidroside Decreases Atherosclerosis Plaque Formation via Inhibiting Endothelial Cell Pyroptosis.
Xing SS, Yang J, Li WJ, Li J, Chen L, Yang YT, Lei X, Li J, Wang K, Liu X. Xing SS, et al. Inflammation. 2020 Apr;43(2):433-440. doi: 10.1007/s10753-019-01106-x. Inflammation. 2020. PMID: 32076940
However, the effect of SAL on atherosclerosis-related pyroptosis has not been studied. Here, we investigated the effect of SAL on pyroptosis to explain the underlying mechanisms of SAL on atherosclerosis-related inflammation. We established an atherosclerosis
However, the effect of SAL on atherosclerosis-related pyroptosis has not been studied. Here, we investigated the effect of SAL on pyr …
Anti-atherosclerosis of oligomeric proanthocyanidins from Rhodiola rosea on rat model via hypolipemic, antioxidant, anti-inflammatory activities together with regulation of endothelial function.
Zhou Q, Han X, Li R, Zhao W, Bai B, Yan C, Dong X. Zhou Q, et al. Phytomedicine. 2018 Dec 1;51:171-180. doi: 10.1016/j.phymed.2018.10.002. Epub 2018 Oct 4. Phytomedicine. 2018. PMID: 30466614
BACKGROUND: Rhodiola rosea has been used as a traditional medicine for a long history. ...HYPOTHESIS/PURPOSE: We hypothesized that OPCRR can improve the atherosclerosis pathological in rats. In the present study, we investigated the effects of OPCRR on the serum lip …
BACKGROUND: Rhodiola rosea has been used as a traditional medicine for a long history. ...HYPOTHESIS/PURPOSE: We hypothesized that OP …
Salidroside protects against ox-LDL-induced endothelial injury by enhancing autophagy mediated by SIRT1-FoxO1 pathway.
Zhu Z, Li J, Zhang X. Zhu Z, et al. BMC Complement Altern Med. 2019 May 30;19(1):111. doi: 10.1186/s12906-019-2526-4. BMC Complement Altern Med. 2019. PMID: 31146723 Free PMC article.
BACKGROUND: Atherosclerosis is a condition with the vascular accumulation of lipid plaques, and its main major contributing factor is endothelial injury induced by oxidized low-density lipoprotein (ox-LDL). Salidroside (SAL) is the primary active ingredient of Rhodiola
BACKGROUND: Atherosclerosis is a condition with the vascular accumulation of lipid plaques, and its main major contributing factor is …
Salidroside simultaneously reduces de novo lipogenesis and cholesterol biosynthesis to attenuate atherosclerosis in mice.
Song T, Wang P, Li C, Jia L, Liang Q, Cao Y, Dong P, Shi H, Jiang M. Song T, et al. Biomed Pharmacother. 2021 Feb;134:111137. doi: 10.1016/j.biopha.2020.111137. Epub 2020 Dec 16. Biomed Pharmacother. 2021. PMID: 33341055 Free article.
Salidroside is a kind of phenylethanoid glycoside and widespread in the plants from Rhodiola and Ligustrum species. Our previous study has reported that salidroside can prevent atherosclerosis progression by ameliorating glyerolipid and glycerophospholipid metabolis …
Salidroside is a kind of phenylethanoid glycoside and widespread in the plants from Rhodiola and Ligustrum species. Our previous stud …
Mechanism of action of Rhodiola, salidroside, tyrosol and triandrin in isolated neuroglial cells: an interactive pathway analysis of the downstream effects using RNA microarray data.
Panossian A, Hamm R, Wikman G, Efferth T. Panossian A, et al. Phytomedicine. 2014 Sep 25;21(11):1325-48. doi: 10.1016/j.phymed.2014.07.008. Epub 2014 Aug 7. Phytomedicine. 2014. PMID: 25172797
AIM: The aim of this study was to identify the targets (genes, interactive signaling pathways, and molecular networks) of Rhodiola rosea extract in isolated neuroglia cells and to predict the effects of Rhodiola extract on cellular functions and diseases. ...The mos …
AIM: The aim of this study was to identify the targets (genes, interactive signaling pathways, and molecular networks) of Rhodiola ro …
Salidroside improves endothelial function and alleviates atherosclerosis by activating a mitochondria-related AMPK/PI3K/Akt/eNOS pathway.
Xing SS, Yang XY, Zheng T, Li WJ, Wu D, Chi JY, Bian F, Bai XL, Wu GJ, Zhang YZ, Zhang CT, Zhang YH, Li YS, Jin S. Xing SS, et al. Vascul Pharmacol. 2015 Sep;72:141-52. doi: 10.1016/j.vph.2015.07.004. Epub 2015 Jul 15. Vascul Pharmacol. 2015. PMID: 26187353
Given the importance of endothelial nitric oxide synthase (eNOS) in atherosclerosis, we sought to elucidate whether SAL could stimulate eNOS activation and also to explore its upstream signaling pathway. ...Taken together, our data described the effects of SAL on mitochond …
Given the importance of endothelial nitric oxide synthase (eNOS) in atherosclerosis, we sought to elucidate whether SAL could stimula …
Salidroside-Mediated Autophagic Targeting of Active Src and Caveolin-1 Suppresses Low-Density Lipoprotein Transcytosis across Endothelial Cells.
Bai X, Jia X, Lu Y, Zhu L, Zhao Y, Cheng W, Shu M, Jin S. Bai X, et al. Oxid Med Cell Longev. 2020 Jun 23;2020:9595036. doi: 10.1155/2020/9595036. eCollection 2020. Oxid Med Cell Longev. 2020. PMID: 32685103 Free PMC article.
Therefore, targeting the crossed pathway in autophagy activation and LDL transcytosis interruption may be a promising antiatherosclerotic strategy. In metabolic diseases, including atherosclerosis, salidroside, a phenylpropanoid glycoside compound (3,5-dimethoxyphenyl) met …
Therefore, targeting the crossed pathway in autophagy activation and LDL transcytosis interruption may be a promising antiatherosclerotic st …
[Effects of rhodiola on expression of vascular endothelial cell growth factor and angiogenesis in aortic atherosclerotic plaque of rabbits].
Shen W, Fan WH, Shi HM. Shen W, et al. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2008 Nov;28(11):1022-5. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2008. PMID: 19213348 Chinese.
OBJECTIVE: To investigate the effects of rhodiola on expression of vascular endothelial cell growth factor (VEGF) and angiogenesis in aortic atherosclerotic plaque of rabbits. ...Besides, the VEGF expression in atherosclerotic plaque was also lower in Group C than that in …
OBJECTIVE: To investigate the effects of rhodiola on expression of vascular endothelial cell growth factor (VEGF) and angiogenesis in …
Salidroside attenuates oxidized low‑density lipoprotein‑induced endothelial cell injury via promotion of the AMPK/SIRT1 pathway.
Zhao D, Sun X, Lv S, Sun M, Guo H, Zhai Y, Wang Z, Dai P, Zheng L, Ye M, Wang X. Zhao D, et al. Int J Mol Med. 2019 Jun;43(6):2279-2290. doi: 10.3892/ijmm.2019.4153. Epub 2019 Apr 1. Int J Mol Med. 2019. PMID: 30942428 Free PMC article.
Oxidized low-density lipoprotein (ox-LDL)-induced endothelial damage contributes to the initiation and pathogenesis of atherosclerosis. Salidroside can alleviate atherosclerosis and attenuate endothelial cell injury induced by ox-LDL. ...
Oxidized low-density lipoprotein (ox-LDL)-induced endothelial damage contributes to the initiation and pathogenesis of atherosclerosis
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