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Riboflavin status, MTHFR genotype and blood pressure: current evidence and implications for personalised nutrition.
McAuley E, McNulty H, Hughes C, Strain JJ, Ward M. McAuley E, et al. Proc Nutr Soc. 2016 Aug;75(3):405-14. doi: 10.1017/S0029665116000197. Epub 2016 May 12. Proc Nutr Soc. 2016. PMID: 27170501 Review.
One important role of riboflavin in the form of flavin dinucleotide is as a co-factor for the folate-metabolising enzyme methylenetetrahydrofolate reductase (MTHFR). ...Evidence is accumulating for a novel role of riboflavin as an important modu …
One important role of riboflavin in the form of flavin dinucleotide is as a co-factor for the folate-metabolising enzyme methylene …
Riboflavin supplements for blood pressure lowering in adults.
Bradbury KE, Coffey S, Earle N, Ni Mhurchu C, Jull AB. Bradbury KE, et al. Cochrane Database Syst Rev. 2025 Oct 22;10(10):CD015464. doi: 10.1002/14651858.CD015464.pub2. Cochrane Database Syst Rev. 2025. PMID: 41123035 Free PMC article.
RATIONALE: Higher blood pressure is strongly related to an increased risk of cardiovascular disease. There has been interest in riboflavin (vitamin B(2)) as a potential intervention to lower blood pressure, particularly for those with a common g …
RATIONALE: Higher blood pressure is strongly related to an increased risk of cardiovascular disease. There has been interest i …
Impact of the MTHFR C677T polymorphism on blood pressure and related central haemodynamic parameters in healthy adults.
Rooney M, Hughes CF, Strain JJ, Clements M, McNulty H, Ward M. Rooney M, et al. J Hum Nutr Diet. 2022 Aug;35(4):689-700. doi: 10.1111/jhn.13061. Epub 2022 Jul 27. J Hum Nutr Diet. 2022. PMID: 35821207 Free PMC article.
BACKGROUND: The C677T polymorphism in the gene-encoding methylenetetrahydrofolate reductase (MTHFR) is associated with an increased risk of hypertension and cardiovascular disease. Riboflavin, the MTHFR cofactor, is an important modulator …
BACKGROUND: The C677T polymorphism in the gene-encoding methylenetetrahydrofolate reductase (MTHFR) is associate …
Postgraduate Symposium: The MTHFR C677T polymorphism, B-vitamins and blood pressure.
Wilson CP, McNulty H, Scott JM, Strain JJ, Ward M. Wilson CP, et al. Proc Nutr Soc. 2010 Feb;69(1):156-65. doi: 10.1017/S0029665109991728. Epub 2009 Dec 3. Proc Nutr Soc. 2010. PMID: 19954568 Review.
High blood pressure (BP) and elevated homocysteine are reported as independent risk factors for CVD and stroke in particular. The main genetic determinant of homocysteine concentrations is homozygosity (TT genotype) for the C677T polymorphism in the methyl …
High blood pressure (BP) and elevated homocysteine are reported as independent risk factors for CVD and stroke in particular. …
DNA methylation of hypertension-related genes and effect of riboflavin supplementation in adults stratified by genotype for the MTHFR C677T polymorphism.
Amenyah SD, Ward M, McMahon A, Deane J, McNulty H, Hughes C, Strain JJ, Horigan G, Purvis J, Walsh CP, Lees-Murdock DJ. Amenyah SD, et al. Int J Cardiol. 2021 Jan 1;322:233-239. doi: 10.1016/j.ijcard.2020.09.011. Epub 2020 Sep 10. Int J Cardiol. 2021. PMID: 32920065
GWAS and observational studies link the C677T polymorphism in methylenetetrahydrofolate reductase (MTHFR) with hypertension, while riboflavin, the MTHFR cofactor, has been shown to reduce blood pressure and global DNA methyl …
GWAS and observational studies link the C677T polymorphism in methylenetetrahydrofolate reductase (MTHFR) with h …
Can riboflavin offer a novel personalised strategy for maintaining healthy blood pressure in pregnancy in populations globally?
Duffy B, Patted A, Boelig RC, Murphy M, Pentieva K, Ward M, Lees-Murdock D, Garcia V, Barry F, Short V, Hughes C, Derman R, McNulty H. Duffy B, et al. BMJ Nutr Prev Health. 2025 Sep 8;8(2):e001212. doi: 10.1136/bmjnph-2025-001212. eCollection 2025. BMJ Nutr Prev Health. 2025. PMID: 41768514 Free PMC article. Review.
In particular, evidence from clinical and genome-wide association studies links the C677T polymorphism in the gene encoding the folate-metabolising enzyme methylenetetrahydrofolate reductase (MTHFR) with blood pressure and an increased ri …
In particular, evidence from clinical and genome-wide association studies links the C677T polymorphism in the gene encoding the folat …
Impact of the MTHFR C677T polymorphism on one-carbon metabolites: Evidence from a randomised trial of riboflavin supplementation.
Rooney M, Bottiglieri T, Wasek-Patterson B, McMahon A, Hughes CF, McCann A, Horigan G, Strain JJ, McNulty H, Ward M. Rooney M, et al. Biochimie. 2020 Jun;173:91-99. doi: 10.1016/j.biochi.2020.04.004. Epub 2020 Apr 21. Biochimie. 2020. PMID: 32330571 Clinical Trial.
Blood pressure (BP) lowering was previously reported in adults with the TT genotype, in response to supplementation with the MTHFR cofactor, riboflavin. ...The genotype-specific, one-carbon metabolite responses to riboflavin intervention observe …
Blood pressure (BP) lowering was previously reported in adults with the TT genotype, in response to supplementation with the …
Critical review of nutrition, blood pressure and risk of hypertension through the lifecycle: do B vitamins play a role?
Psara E, Pentieva K, Ward M, McNulty H. Psara E, et al. Biochimie. 2020 Jun;173:76-90. doi: 10.1016/j.biochi.2020.03.016. Epub 2020 Apr 11. Biochimie. 2020. PMID: 32289470 Review.
The association of obesity, physical inactivity and alcohol with elevated blood pressure (BP) is firmly established. Weight loss or other dietary strategies, such as the Dietary Approaches to Stop Hypertension (DASH) diet, have been shown to be effective in lowering …
The association of obesity, physical inactivity and alcohol with elevated blood pressure (BP) is firmly established. Weight lo …
Riboflavin supplementation alters global and gene-specific DNA methylation in adults with the MTHFR 677 TT genotype.
Amenyah SD, McMahon A, Ward M, Deane J, McNulty H, Hughes CF, Strain JJ, Horigan G, Purvis J, Walsh CP, Lees-Murdock DJ. Amenyah SD, et al. Biochimie. 2020 Jun;173:17-26. doi: 10.1016/j.biochi.2020.04.007. Epub 2020 Apr 22. Biochimie. 2020. PMID: 32334045
A polymorphism (C677T) in MTHFR results in decreased MTHFR activity and increased homocysteine concentration. ...Samples were accessed from participants, screened for the MTHFR C677T polymorphism, who participated in observational (n = 80) and t …
A polymorphism (C677T) in MTHFR results in decreased MTHFR activity and increased homocysteine concentration. ...Sample …
C(1) metabolism and CVD outcomes in older adults.
McNulty H, Strain JJ, Pentieva K, Ward M. McNulty H, et al. Proc Nutr Soc. 2012 May;71(2):213-21. doi: 10.1017/S0029665111003387. Epub 2011 Dec 12. Proc Nutr Soc. 2012. PMID: 22152927 Review.
Genetic studies provide convincing evidence to support a causal relationship between sub-optimal B-vitamin status and CVD. People homozygous for the common C677T variant in the gene encoding the folate-metabolising enzyme, methylenetetrahydrofolate reductase …
Genetic studies provide convincing evidence to support a causal relationship between sub-optimal B-vitamin status and CVD. People homozygous …
13 results