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Page 1
Mitochondrial function and toxicity: role of the B vitamin family on mitochondrial energy metabolism.
Depeint F, Bruce WR, Shangari N, Mehta R, O'Brien PJ. Depeint F, et al. Chem Biol Interact. 2006 Oct 27;163(1-2):94-112. doi: 10.1016/j.cbi.2006.04.014. Epub 2006 May 1. Chem Biol Interact. 2006. PMID: 16765926 Review.
Pantothenic acid (B5) is required for coenzyme A formation and is also essential for alpha-ketoglutarate and pyruvate dehydrogenase complexes as well as fatty acid oxidation. Biotin (B7) is the coenzyme of decarboxylases required for gluconeogenesis an …
Pantothenic acid (B5) is required for coenzyme A formation and is also essential for alpha-ketoglutarate and pyruvate dehydrogenase c …
Nrf2 affects the efficiency of mitochondrial fatty acid oxidation.
Ludtmann MH, Angelova PR, Zhang Y, Abramov AY, Dinkova-Kostova AT. Ludtmann MH, et al. Biochem J. 2014 Feb 1;457(3):415-24. doi: 10.1042/BJ20130863. Biochem J. 2014. PMID: 24206218 Free PMC article.
Thus this transcription factor negatively affects fatty acid synthesis. However, the effect of Nrf2 on fatty acid oxidation is currently unknown. ...Addition of fatty acids stimulates respiration in heart and liver mitochondria …
Thus this transcription factor negatively affects fatty acid synthesis. However, the effect of Nrf2 on fatty acid …
Emerging roles for riboflavin in functional rescue of mitochondrial beta-oxidation flavoenzymes.
Henriques BJ, Olsen RK, Bross P, Gomes CM. Henriques BJ, et al. Curr Med Chem. 2010;17(32):3842-54. doi: 10.2174/092986710793205462. Curr Med Chem. 2010. PMID: 20858216 Review.
The role of this vitamin in mitochondrial metabolism, and in particular in fatty acid oxidation, will be discussed in this review. The basic aspects concerning riboflavin and flavin metabolism and deficiency will be addressed, as well as …
The role of this vitamin in mitochondrial metabolism, and in particular in fatty acid oxidation, will be …
Riboflavin Increases Goat Sperm Motility via Enhancement of Mitochondrial beta-Oxidation.
Wang Q, Zhang N, Sun L, Ding P, Zhao S, Ma D, Kou X, Zhu Z, Min L. Wang Q, et al. Biology (Basel). 2025 Dec 31;15(1):85. doi: 10.3390/biology15010085. Biology (Basel). 2025. PMID: 41514925 Free PMC article.
Mitochondrial energy metabolism is fundamental to sperm function, and fatty acid beta-oxidation is an important pathway for adenosine triphosphate (ATP) production. Riboflavin, a precursor of key flavin cofactors, plays a critical role in …
Mitochondrial energy metabolism is fundamental to sperm function, and fatty acid beta-oxidation is an important …
Disturbed bovine mitochondrial lipid metabolism: a review.
Han van der Kolk JH, Gross JJ, Gerber V, Bruckmaier RM. Han van der Kolk JH, et al. Vet Q. 2017 Dec;37(1):262-273. doi: 10.1080/01652176.2017.1354561. Vet Q. 2017. PMID: 28712316 Free article. Review.
Of note, around parturition concurrent oxidation of fatty acids in skeletal muscle is highly activated. Also peroxisomal beta-oxidation in liver of dairy cows may be part of the hepatic adaptations to a negative energy balance (NEB) to break down fa …
Of note, around parturition concurrent oxidation of fatty acids in skeletal muscle is highly activated. Also peroxisoma …
Riboflavin Deficiency-Implications for General Human Health and Inborn Errors of Metabolism.
Mosegaard S, Dipace G, Bross P, Carlsen J, Gregersen N, Olsen RKJ. Mosegaard S, et al. Int J Mol Sci. 2020 May 28;21(11):3847. doi: 10.3390/ijms21113847. Int J Mol Sci. 2020. PMID: 32481712 Free PMC article. Review.
As an essential vitamin, the role of riboflavin in human diet and health is increasingly being highlighted. Insufficient dietary intake of riboflavin is often reported in nutritional surveys and population studies, even in non-developing countries with abunda …
As an essential vitamin, the role of riboflavin in human diet and health is increasingly being highlighted. Insufficient dieta …
Electron transfer flavoprotein and its role in mitochondrial energy metabolism in health and disease.
Henriques BJ, Katrine Jentoft Olsen R, Gomes CM, Bross P. Henriques BJ, et al. Gene. 2021 Apr 15;776:145407. doi: 10.1016/j.gene.2021.145407. Epub 2021 Jan 13. Gene. 2021. PMID: 33450351 Free PMC article. Review.
After translation, the two subunits are imported to the mitochondrial matrix space and assemble into a heterodimer containing one FAD and one AMP as cofactors. ...This represents a major source of reducing power for the electron transport chain from fatty acid …
After translation, the two subunits are imported to the mitochondrial matrix space and assemble into a heterodimer containing one FAD …
Mitochondrial FAD shortage in SLC25A32 deficiency affects folate-mediated one-carbon metabolism.
Peng MZ, Shao YX, Li XZ, Zhang KD, Cai YN, Lin YT, Jiang MY, Liu ZC, Su XY, Zhang W, Jiang XL, Liu L. Peng MZ, et al. Cell Mol Life Sci. 2022 Jun 21;79(7):375. doi: 10.1007/s00018-022-04404-0. Cell Mol Life Sci. 2022. PMID: 35727412 Free PMC article.
None of the Slc25a32 mutations hindered the mitochondrial uptake of folate. Instead, the mitochondrial uptake of flavin adenine dinucleotide (FAD) was specifically blocked by Slc25a32(Y174C/K235R), Slc25a32(K235R/K235R), and Slc25a32(-/-) mutations. A positive corre …
None of the Slc25a32 mutations hindered the mitochondrial uptake of folate. Instead, the mitochondrial uptake of flavin adenin …
Late-Onset Multiple Acyl-CoA Dehydrogenase Deficiency (MADD): Clinical Features, Diagnostic Challenges, and the Role of Oxidative Stress in Pathophysiology.
Zoppi D, Russo A, Vallefuoco F, De Maria M, Esposito G, Fioretti T, Maiolo V, Santorelli FM, Iodice R, Tozza S, Dubbioso R, Manganelli F, Ruggiero L. Zoppi D, et al. Antioxidants (Basel). 2025 Nov 26;14(12):1409. doi: 10.3390/antiox14121409. Antioxidants (Basel). 2025. PMID: 41462609 Free PMC article.
INTRODUCTION: Multiple Acyl-CoA Dehydrogenase Deficiency (MADD) is an autosomal recessive metabolic disorder resulting from mutations in the genes that encode the electron transfer flavoprotein (ETF) or its associated dehydrogenase (ETFDH), resulting in defects in mitochondria …
INTRODUCTION: Multiple Acyl-CoA Dehydrogenase Deficiency (MADD) is an autosomal recessive metabolic disorder resulting from mutations in the …
Oxygen radicals shaping evolution: why fatty acid catabolism leads to peroxisomes while neurons do without it: FADH2/NADH flux ratios determining mitochondrial radical formation were crucial for the eukaryotic invention of peroxisomes and catabolic tissue differentiation.
Speijer D. Speijer D. Bioessays. 2011 Feb;33(2):88-94. doi: 10.1002/bies.201000097. Bioessays. 2011. PMID: 21137096
This means that very long chain fatty acids should be broken down without generation of FADH2 for mitochondria. This is accomplished in peroxisomes, thus explaining their role and evolution. ...It also sheds light on the reasons for the lack of neurona …
This means that very long chain fatty acids should be broken down without generation of FADH2 for mitochondria. This is …
18 results