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628 results

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Page 1
Eukaryotic Ribosome Assembly.
Vanden Broeck A, Klinge S. Vanden Broeck A, et al. Annu Rev Biochem. 2024 Aug;93(1):189-210. doi: 10.1146/annurev-biochem-030222-113611. Epub 2024 Jul 2. Annu Rev Biochem. 2024. PMID: 38768392 Free article. Review.
During the last ten years, developments in cryo-electron microscopy have transformed our understanding of eukaryotic ribosome assembly. As a result, the field has advanced from a list of the vast array of ribosome assembly factors toward an emerging molecular movie …
During the last ten years, developments in cryo-electron microscopy have transformed our understanding of eukaryotic ribosome assembl …
Principles of human pre-60S biogenesis.
Vanden Broeck A, Klinge S. Vanden Broeck A, et al. Science. 2023 Jul 7;381(6653):eadh3892. doi: 10.1126/science.adh3892. Epub 2023 Jul 7. Science. 2023. PMID: 37410842 Free article.
During the early stages of human large ribosomal subunit (60S) biogenesis, an ensemble of assembly factors establishes and fine-tunes the essential RNA functional centers of pre-60S particles by an unknown mechanism. ...Nuclear stages highlight how a c …
During the early stages of human large ribosomal subunit (60S) biogenesis, an ensemble of assembly factors estab …
Assembly landscape for the bacterial large ribosomal subunit.
Sheng K, Li N, Rabuck-Gibbons JN, Dong X, Lyumkis D, Williamson JR. Sheng K, et al. Nat Commun. 2023 Aug 26;14(1):5220. doi: 10.1038/s41467-023-40859-w. Nat Commun. 2023. PMID: 37633970 Free PMC article.
We use cryo-electron microscopy, with iterative subclassification to identify intermediates in the assembly of the 50S ribosomal subunit from E. coli. The analysis of the ensemble of intermediates that spans the entire biogenesis pathway for the 50 S subun …
We use cryo-electron microscopy, with iterative subclassification to identify intermediates in the assembly of the 50S ribosomal s …
Mechanistic insight into eukaryotic 60S ribosomal subunit biogenesis by cryo-electron microscopy.
Greber BJ. Greber BJ. RNA. 2016 Nov;22(11):1643-1662. doi: 10.1261/rna.057927.116. RNA. 2016. PMID: 27875256 Free PMC article. Review.
Here, I review recent structural and mechanistic insights into the biogenesis of the large ribosomal subunit that were furthered by cryo-electron microscopy of natively purified pre-60S particles and in vitro reconstituted ribosome assembly fact …
Here, I review recent structural and mechanistic insights into the biogenesis of the large ribosomal subunit tha …
Ribosomal biogenesis defects trigger subunit specific developmental checkpoints via TOR signaling and gap junction in C. elegans.
Surya A, Zhao Q, Voigt B, Rangan R, Cenik ES. Surya A, et al. Dev Biol. 2026 Jan;529:46-55. doi: 10.1016/j.ydbio.2025.10.003. Epub 2025 Oct 3. Dev Biol. 2026. PMID: 41047111 Free article.
Genetic analyses further implicated the gap junction protein INX-14 and the TORC2 component SINH-1 as partial suppressors of the M cell arrest in small ribosomal subunit mutants (rps-23(0)), but not in large ribosomal subunit mutants (rpl-5(0)). …
Genetic analyses further implicated the gap junction protein INX-14 and the TORC2 component SINH-1 as partial suppressors of the M cell arre …
Mechanism of mitoribosomal small subunit biogenesis and preinitiation.
Itoh Y, Khawaja A, Laptev I, Cipullo M, Atanassov I, Sergiev P, Rorbach J, Amunts A. Itoh Y, et al. Nature. 2022 Jun;606(7914):603-608. doi: 10.1038/s41586-022-04795-x. Epub 2022 Jun 8. Nature. 2022. PMID: 35676484 Free PMC article.
Here we use cryo-electron microscopy to determine a series of the small mitoribosomal subunit (SSU) intermediates in complex with auxiliary factors, revealing a sequential assembly mechanism. ...This enables binding of METTL15 that promotes further rRNA maturation and a …
Here we use cryo-electron microscopy to determine a series of the small mitoribosomal subunit (SSU) intermediates in complex with aux …
Ribosomal RNA modification enzymes stimulate large ribosome subunit assembly in E. coli.
Ero R, Leppik M, Reier K, Liiv A, Remme J. Ero R, et al. Nucleic Acids Res. 2024 Jun 24;52(11):6614-6628. doi: 10.1093/nar/gkae222. Nucleic Acids Res. 2024. PMID: 38554109 Free PMC article.
Ribosomal RNA modifications are introduced by specific enzymes during ribosome assembly in bacteria. ...The results demonstrate that in addition to previously known RlmE, also RlmB, RlmKL, RlmN and RluC facilitate large ribosome subunit assembly …
Ribosomal RNA modifications are introduced by specific enzymes during ribosome assembly in bacteria. ...The results demonstrat …
Making ends meet: a universal driver of large ribosomal subunit biogenesis.
Bohnsack KE, Henras AK, Nielsen H, Bohnsack MT. Bohnsack KE, et al. Trends Biochem Sci. 2023 Mar;48(3):213-215. doi: 10.1016/j.tibs.2022.09.003. Epub 2022 Oct 4. Trends Biochem Sci. 2023. PMID: 36207216 Free article.
A common aspect of ribosome assembly, conserved across all domains of life, is the establishment of connections between the 5' and 3' ends of the large subunit (LSU) ribosomal RNA (rRNA) to initiate rRNA domain compaction and subunit asse …
A common aspect of ribosome assembly, conserved across all domains of life, is the establishment of connections between the 5' …
Interconnected assembly factors regulate the biogenesis of mitoribosomal large subunit.
Tobiasson V, Gahura O, Aibara S, Baradaran R, Zíková A, Amunts A. Tobiasson V, et al. EMBO J. 2021 Mar 15;40(6):e106292. doi: 10.15252/embj.2020106292. Epub 2021 Feb 12. EMBO J. 2021. PMID: 33576519 Free PMC article.
We used mitoribosomes from Trypanosoma brucei with reduced RNA and increased protein mass to provide insights into the biogenesis of the mitoribosomal large subunit. Structural characterization of a stable assembly intermediate revealed 22 assembly factors, s …
We used mitoribosomes from Trypanosoma brucei with reduced RNA and increased protein mass to provide insights into the biogenesis of …
E3 ubiquitin ligase RNF10 promotes dissociation of stalled ribosomes and responds to ribosomal subunit imbalance.
Lehmann JA, Lindner D, Sung HM, Stoecklin G. Lehmann JA, et al. Nat Commun. 2024 Nov 28;15(1):10350. doi: 10.1038/s41467-024-54411-x. Nat Commun. 2024. PMID: 39609413 Free PMC article.
Aberrant translation causes ribosome stalling, which leads to the ubiquitination of ribosomal proteins and induces ribosome-associated quality control. ...Knockdown of RPS proteins, which abrogates 40S ribosome biogenesis, results in proteasomal …
Aberrant translation causes ribosome stalling, which leads to the ubiquitination of ribosomal proteins and induces ribosome …
628 results