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236,951 results

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Page 1
Ribosomes and translation.
Green R, Noller HF. Green R, et al. Annu Rev Biochem. 1997;66:679-716. doi: 10.1146/annurev.biochem.66.1.679. Annu Rev Biochem. 1997. PMID: 9242921 Review.
The ribosome is a large multifunctional complex composed of both RNA and proteins. Biophysical methods are yielding low-resolution structures of the overall architecture of ribosomes, and high-resolution structures of individual proteins and segments of rRNA. Accumu …
The ribosome is a large multifunctional complex composed of both RNA and proteins. Biophysical methods are yielding low-resolution st …
The space between notes: emerging roles for translationally silent ribosomes.
Smith PR, Pandit SC, Loerch S, Campbell ZT. Smith PR, et al. Trends Biochem Sci. 2022 Jun;47(6):477-491. doi: 10.1016/j.tibs.2022.02.003. Epub 2022 Mar 1. Trends Biochem Sci. 2022. PMID: 35246374 Free PMC article. Review.
Vacant ribosomes may provide a means to exclude ribosomes from translation while also shielding them from degradation, and the variable identity of factors that occlude ribosomes may impart distinct functionality. We propose that regulated changes in the bala …
Vacant ribosomes may provide a means to exclude ribosomes from translation while also shielding them from degradation, and the …
Engineered Ribosomes for Basic Science and Synthetic Biology.
d'Aquino AE, Kim DS, Jewett MC. d'Aquino AE, et al. Annu Rev Chem Biomol Eng. 2018 Jun 7;9:311-340. doi: 10.1146/annurev-chembioeng-060817-084129. Epub 2018 Mar 28. Annu Rev Chem Biomol Eng. 2018. PMID: 29589973 Review.
Despite these efforts, the potential for harnessing the translation apparatus to manufacture bio-based products beyond natural limits remains underexploited, and fundamental constraints on the chemistry that the ribosome's RNA-based active site can carry out are unk …
Despite these efforts, the potential for harnessing the translation apparatus to manufacture bio-based products beyond natural limits remain …
Discovery of Mitochondrial Ribosomes.
O'Brien TW. O'Brien TW. Methods Mol Biol. 2023;2661:3-5. doi: 10.1007/978-1-0716-3171-3_1. Methods Mol Biol. 2023. PMID: 37166628
The Beak of Eukaryotic Ribosomes: Life, Work and Miracles.
Martín-Villanueva S, Galmozzi CV, Ruger-Herreros C, Kressler D, de la Cruz J. Martín-Villanueva S, et al. Biomolecules. 2024 Jul 22;14(7):882. doi: 10.3390/biom14070882. Biomolecules. 2024. PMID: 39062596 Free PMC article. Review.
Ribosomes are not totally globular machines. Instead, they comprise prominent structural protrusions and a myriad of tentacle-like projections, which are frequently made up of ribosomal RNA expansion segments and N- or C-terminal extensions of ribosomal prote …
Ribosomes are not totally globular machines. Instead, they comprise prominent structural protrusions and a myriad of tentacle-like pr …
snoRNAs in making "snoman" ribosomes.
Dabrowska A, Ruggero D. Dabrowska A, et al. Mol Cell. 2024 Aug 22;84(16):3008-3010. doi: 10.1016/j.molcel.2024.07.029. Mol Cell. 2024. PMID: 39178837
In a recent study in Cell, Cheng and Wang et al.(1) show that the small nucleolar RNA (snoRNA) SNORA13 has a non-canonical role in ribosome biogenesis and senescence by acting directly on RPL23 and regulating its assembly into the 60S ribosomal subunit....
In a recent study in Cell, Cheng and Wang et al.(1) show that the small nucleolar RNA (snoRNA) SNORA13 has a non-canonical role in riboso …
Ribosomes: from conserved origin to functional/medical mobility and heterogeneity.
Rivalta A, Hiregange DG, Bose T, Rajan KS, Yonath A, Zimmerman E, Waghalter M, Fridkin G, Martinez-Roman I, Rosenfield L, Fedorenko A, Bashan A, Yonath H. Rivalta A, et al. Philos Trans R Soc Lond B Biol Sci. 2025 Mar 6;380(1921):20230393. doi: 10.1098/rstb.2023.0393. Epub 2025 Mar 6. Philos Trans R Soc Lond B Biol Sci. 2025. PMID: 40045780 Free PMC article. Review.
Ribosomes, the molecular machines that translate the genetic code from mRNA into proteins in all living cells, are highly structurally conserved across all domains of life and hence are believed to have evolved from a structurally unified pocket. ...These findings should p …
Ribosomes, the molecular machines that translate the genetic code from mRNA into proteins in all living cells, are highly structurall …
Pre-ribosomes on the road from the nucleolus to the cytoplasm.
Tschochner H, Hurt E. Tschochner H, et al. Trends Cell Biol. 2003 May;13(5):255-63. doi: 10.1016/s0962-8924(03)00054-0. Trends Cell Biol. 2003. PMID: 12742169 Review.
Eukaryotic ribosomes are assembled in the nucleolus before export to the cytoplasm. Ribosome formation is a highly dynamic and coordinated multistep process, which requires synthesis, processing and modification of pre-rRNAs, assembly with ribosomal proteins …
Eukaryotic ribosomes are assembled in the nucleolus before export to the cytoplasm. Ribosome formation is a highly dynamic and …
Nascent ribosomes.
Warner JR. Warner JR. Cell. 2001 Oct 19;107(2):133-6. doi: 10.1016/s0092-8674(01)00531-1. Cell. 2001. PMID: 11672521 Free article. Review.
The conversion of a ribosomal RNA transcript to a cytoplasmic ribosome requires hundreds of accessory RNA and protein factors. Two papers published recently in Molecular Cell provide first looks at the association of these processing factors with the intermediates i …
The conversion of a ribosomal RNA transcript to a cytoplasmic ribosome requires hundreds of accessory RNA and protein factors. …
Ribosome biogenesis in cancer: new players and therapeutic avenues.
Pelletier J, Thomas G, Volarević S. Pelletier J, et al. Nat Rev Cancer. 2018 Jan;18(1):51-63. doi: 10.1038/nrc.2017.104. Epub 2017 Dec 1. Nat Rev Cancer. 2018. PMID: 29192214 Review.
The ribosome is a complex molecular machine composed of numerous distinct proteins and nucleic acids and is responsible for protein synthesis in every living cell. ...Although causal associations between inherited mutations affecting ribosome biogenesis and elevated …
The ribosome is a complex molecular machine composed of numerous distinct proteins and nucleic acids and is responsible for protein s …
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