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1992 3
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The advent of oncolytic virotherapy in oncology: The Rigvir story.
Alberts P, Tilgase A, Rasa A, Bandere K, Venskus D. Alberts P, et al. Eur J Pharmacol. 2018 Oct 15;837:117-126. doi: 10.1016/j.ejphar.2018.08.042. Epub 2018 Sep 1. Eur J Pharmacol. 2018. PMID: 30179611 Free article. Review.
Safety of the selected and melanoma-adapted ECHO-7 virus Rigvir was tested in over 180 patients with no severe adverse events observed. ...In post-marketing retrospective studies, Rigvir-treated stage II melanoma patients showed a 6.67-fold decreased risk for diseas …
Safety of the selected and melanoma-adapted ECHO-7 virus Rigvir was tested in over 180 patients with no severe adverse events observe …
Oncolytic virotherapy including Rigvir and standard therapies in malignant melanoma.
Babiker HM, Riaz IB, Husnain M, Borad MJ. Babiker HM, et al. Oncolytic Virother. 2017 Feb 9;6:11-18. doi: 10.2147/OV.S100072. eCollection 2017. Oncolytic Virother. 2017. PMID: 28224120 Free PMC article. Review.
This is certainly a burgeoning time in immunotherapy drug development, and the aforementioned efforts along with the recent US Food and Drug Administration approval of talimogene laherparepvec (T-VEC), a recombinant oncolytic herpes virus, have paved the way to exploring the role …
This is certainly a burgeoning time in immunotherapy drug development, and the aforementioned efforts along with the recent US Food and Drug …
Cytolytic Properties and Genome Analysis of Rigvir() Oncolytic Virotherapy Virus and Other Echovirus 7 Isolates.
Hietanen E, Koivu MKA, Susi P. Hietanen E, et al. Viruses. 2022 Mar 4;14(3):525. doi: 10.3390/v14030525. Viruses. 2022. PMID: 35336934 Free PMC article.
Rigvir() is a cell-adapted, oncolytic virotherapy enterovirus, which derives from an echovirus 7 (E7) isolate. ...A phylogenetic analysis of the full-length data suggested that Rigvir() was most distant from the other E7 isolates used in this study, placing Rigvi
Rigvir() is a cell-adapted, oncolytic virotherapy enterovirus, which derives from an echovirus 7 (E7) isolate. ...A phylogenetic anal
Stage IIA Skin Melanoma Treatment With ECHO-7 Oncolytic Virus Rigvir.
Čēma I, Kleina R, Doniņa S, Isajevs S, Zablocka T, Rasa A, Alberts P. Čēma I, et al. Perm J. 2022 Sep 14;26(3):139-144. doi: 10.7812/TPP/21.232. Epub 2022 Aug 11. Perm J. 2022. PMID: 35950985 Free PMC article.
In this report, the authors describe a patient with stage IIA skin melanoma treated with surgery and Rigvir virotherapy. Two years after the patient discovered a brown spot on the right cheek, surgery was indicated because the mass had started to ulcerate. Rigvir vi …
In this report, the authors describe a patient with stage IIA skin melanoma treated with surgery and Rigvir virotherapy. Two years af …
Oncolytic virus preclinical toxicology studies.
Rasa A, Alberts P. Rasa A, et al. J Appl Toxicol. 2023 May;43(5):620-648. doi: 10.1002/jat.4408. Epub 2022 Nov 7. J Appl Toxicol. 2023. PMID: 36299168 Review.
This article summarizes the preclinical toxicology studies of the most well studied oncolytic viruses, including Oncorine, Talimogene laherparepvec, Cavatak, ONYX-015, teserpaturev and Rigvir, a non-pathogenic ECHO-7 virus. It is concluded that oncolytic viruses have been …
This article summarizes the preclinical toxicology studies of the most well studied oncolytic viruses, including Oncorine, Talimogene laherp …
Effect of oncolytic ECHO-7 virus strain Rigvir on uveal melanoma cell lines.
Tilgase A, Grīne L, Blāķe I, Borodušķis M, Rasa A, Alberts P. Tilgase A, et al. BMC Res Notes. 2020 Apr 16;13(1):222. doi: 10.1186/s13104-020-05068-4. BMC Res Notes. 2020. PMID: 32299493 Free PMC article.
Preclinical results show cytolytic activity of enteric cytopathic human orphan virus type 7 (ECHO-7) strain Rigvir in human melanoma, rhabdomyosarcoma, gastric adenocarcinoma, lung carcinoma and pancreas adenocarcinoma cell lines. ...RESULTS: The results suggest cytolytic …
Preclinical results show cytolytic activity of enteric cytopathic human orphan virus type 7 (ECHO-7) strain Rigvir in human melanoma, …
Reply to Alberts, P. Comment on "Hietanen et al. Cytolytic Properties and Genome Analysis of Rigvir() Oncolytic Virotherapy Virus and Other Echovirus 7 Isolates. Viruses 2022, 14, 525".
Hietanen E, Susi P. Hietanen E, et al. Viruses. 2022 Sep 19;14(9):2078. doi: 10.3390/v14092078. Viruses. 2022. PMID: 36146884 Free PMC article.
Our work focused on comparing the cellular effects of Rigvir to other echovirus 7 isolates, because originally Rigvir is also an echovirus 7 isolate [...]....
Our work focused on comparing the cellular effects of Rigvir to other echovirus 7 isolates, because originally Rigvir is also …
Effect of the oncolytic ECHO-7 virus Rigvir on the viability of cell lines of human origin in vitro.
Tilgase A, Patetko L, Blāķe I, Ramata-Stunda A, Borodušķis M, Alberts P. Tilgase A, et al. J Cancer. 2018 Feb 28;9(6):1033-1049. doi: 10.7150/jca.23242. eCollection 2018. J Cancer. 2018. PMID: 29581783 Free PMC article.
The aims of the present study are to test the effect of Rigvir on cell line viability in vitro and to visualize the cellular presence of Rigvir by immunocytochemistry. ...Further studies of possible Rigvir entry receptors are needed....
The aims of the present study are to test the effect of Rigvir on cell line viability in vitro and to visualize the cellular presence …
4-Week repeated dose rat GLP toxicity study of oncolytic ECHO-7 virus Rigvir administered intramuscularly with a 4-week recovery period.
Piwoni K, Jaeckel G, Rasa A, Alberts P. Piwoni K, et al. Toxicol Rep. 2021 Jan 19;8:230-238. doi: 10.1016/j.toxrep.2021.01.009. eCollection 2021. Toxicol Rep. 2021. PMID: 33537211 Free PMC article.
The oncolytic ECHO-7 virus Rigvir was registered in Latvia in 2004 and later in Georgia, Armenia and Uzbekistan. ...In addition, the biodistribution of Rigvir in selected tissues was determined....
The oncolytic ECHO-7 virus Rigvir was registered in Latvia in 2004 and later in Georgia, Armenia and Uzbekistan. ...In addition, the …
ECHO-7 oncolytic virus Rigvir in an adjuvant setting for stage I uveal melanoma; A retrospective case report.
Jaunalksne I, Brokāne L, Petroška D, Rasa A, Alberts P. Jaunalksne I, et al. Am J Ophthalmol Case Rep. 2020 Jan 31;17:100615. doi: 10.1016/j.ajoc.2020.100615. eCollection 2020 Mar. Am J Ophthalmol Case Rep. 2020. PMID: 32072076 Free PMC article.
PURPOSE: To describe a case of choroidal melanoma treated with Rigvir virotherapy in an adjuvant setting. OBSERVATIONS: A female patient born in 1956 presented with a small choroidal melanoma in October 2007. 34 months after transpupillary thermotherapy the state of her ey …
PURPOSE: To describe a case of choroidal melanoma treated with Rigvir virotherapy in an adjuvant setting. OBSERVATIONS: A female pati …
33 results