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Page 1
The advent of oncolytic virotherapy in oncology: The Rigvir story.
Alberts P, Tilgase A, Rasa A, Bandere K, Venskus D. Alberts P, et al. Eur J Pharmacol. 2018 Oct 15;837:117-126. doi: 10.1016/j.ejphar.2018.08.042. Epub 2018 Sep 1. Eur J Pharmacol. 2018. PMID: 30179611 Free article. Review.
Patients were treated with Rigvir for 3 years after surgery and compared to immunotherapy: 3- and 5-year overall survival appeared to be increased in Rigvir treated patients. In post-marketing retrospective studies, Rigvir-treated stage II melanoma patients s …
Patients were treated with Rigvir for 3 years after surgery and compared to immunotherapy: 3- and 5-year overall survival appeared to …
Cytolytic Properties and Genome Analysis of Rigvir() Oncolytic Virotherapy Virus and Other Echovirus 7 Isolates.
Hietanen E, Koivu MKA, Susi P. Hietanen E, et al. Viruses. 2022 Mar 4;14(3):525. doi: 10.3390/v14030525. Viruses. 2022. PMID: 35336934 Free PMC article.
Rigvir() is a cell-adapted, oncolytic virotherapy enterovirus, which derives from an echovirus 7 (E7) isolate. ...A phylogenetic analysis of the full-length data suggested that Rigvir() was most distant from the other E7 isolates used in this study, placing Rigvi …
Rigvir() is a cell-adapted, oncolytic virotherapy enterovirus, which derives from an echovirus 7 (E7) isolate. ...A phylogenetic anal …
Oncolytic virotherapy including Rigvir and standard therapies in malignant melanoma.
Babiker HM, Riaz IB, Husnain M, Borad MJ. Babiker HM, et al. Oncolytic Virother. 2017 Feb 9;6:11-18. doi: 10.2147/OV.S100072. eCollection 2017. Oncolytic Virother. 2017. PMID: 28224120 Free PMC article. Review.
This is certainly a burgeoning time in immunotherapy drug development, and the aforementioned efforts along with the recent US Food and Drug Administration approval of talimogene laherparepvec (T-VEC), a recombinant oncolytic herpes virus, have paved the way to exploring the role …
This is certainly a burgeoning time in immunotherapy drug development, and the aforementioned efforts along with the recent US Food and Drug …
Stage IIA Skin Melanoma Treatment With ECHO-7 Oncolytic Virus Rigvir.
Čēma I, Kleina R, Doniņa S, Isajevs S, Zablocka T, Rasa A, Alberts P. Čēma I, et al. Perm J. 2022 Sep 14;26(3):139-144. doi: 10.7812/TPP/21.232. Epub 2022 Aug 11. Perm J. 2022. PMID: 35950985 Free PMC article.
In this report, the authors describe a patient with stage IIA skin melanoma treated with surgery and Rigvir virotherapy. Two years after the patient discovered a brown spot on the right cheek, surgery was indicated because the mass had started to ulcerate. Rigvir vi …
In this report, the authors describe a patient with stage IIA skin melanoma treated with surgery and Rigvir virotherapy. Two years af …
Reply to Alberts, P. Comment on "Hietanen et al. Cytolytic Properties and Genome Analysis of Rigvir() Oncolytic Virotherapy Virus and Other Echovirus 7 Isolates. Viruses 2022, 14, 525".
Hietanen E, Susi P. Hietanen E, et al. Viruses. 2022 Sep 19;14(9):2078. doi: 10.3390/v14092078. Viruses. 2022. PMID: 36146884 Free PMC article.
Our work focused on comparing the cellular effects of Rigvir to other echovirus 7 isolates, because originally Rigvir is also an echovirus 7 isolate [...]....
Our work focused on comparing the cellular effects of Rigvir to other echovirus 7 isolates, because originally Rigvir is also …
Effect of oncolytic ECHO-7 virus strain Rigvir on uveal melanoma cell lines.
Tilgase A, Grīne L, Blāķe I, Borodušķis M, Rasa A, Alberts P. Tilgase A, et al. BMC Res Notes. 2020 Apr 16;13(1):222. doi: 10.1186/s13104-020-05068-4. BMC Res Notes. 2020. PMID: 32299493 Free PMC article.
Preclinical results show cytolytic activity of enteric cytopathic human orphan virus type 7 (ECHO-7) strain Rigvir in human melanoma, rhabdomyosarcoma, gastric adenocarcinoma, lung carcinoma and pancreas adenocarcinoma cell lines. ...RESULTS: The results suggest cytolytic …
Preclinical results show cytolytic activity of enteric cytopathic human orphan virus type 7 (ECHO-7) strain Rigvir in human melanoma, …
ECHO-7 oncolytic virus Rigvir in an adjuvant setting for stage I uveal melanoma; A retrospective case report.
Jaunalksne I, Brokāne L, Petroška D, Rasa A, Alberts P. Jaunalksne I, et al. Am J Ophthalmol Case Rep. 2020 Jan 31;17:100615. doi: 10.1016/j.ajoc.2020.100615. eCollection 2020 Mar. Am J Ophthalmol Case Rep. 2020. PMID: 32072076 Free PMC article.
PURPOSE: To describe a case of choroidal melanoma treated with Rigvir virotherapy in an adjuvant setting. OBSERVATIONS: A female patient born in 1956 presented with a small choroidal melanoma in October 2007. 34 months after transpupillary thermotherapy the state of her ey …
PURPOSE: To describe a case of choroidal melanoma treated with Rigvir virotherapy in an adjuvant setting. OBSERVATIONS: A female pati …
Combination treatment with nivolumab and Rigvir of a progressive stage IIC skin melanoma patient.
Brokāne L, Jaunalksne I, Tilgase A, Olmane E, Petroška D, Rasa A, Alberts P. Brokāne L, et al. Clin Case Rep. 2019 May 8;7(6):1191-1196. doi: 10.1002/ccr3.2182. eCollection 2019 Jun. Clin Case Rep. 2019. PMID: 31183092 Free PMC article.
Treatment was continued with radiotherapy, which did not stop further spread of disease and the patient was put on a combination of nivolumab and Rigvir. Subsequently, the progression has slowed....
Treatment was continued with radiotherapy, which did not stop further spread of disease and the patient was put on a combination of nivoluma …
Oncolytic virus preclinical toxicology studies.
Rasa A, Alberts P. Rasa A, et al. J Appl Toxicol. 2023 May;43(5):620-648. doi: 10.1002/jat.4408. Epub 2022 Nov 7. J Appl Toxicol. 2023. PMID: 36299168 Review.
This article summarizes the preclinical toxicology studies of the most well studied oncolytic viruses, including Oncorine, Talimogene laherparepvec, Cavatak, ONYX-015, teserpaturev and Rigvir, a non-pathogenic ECHO-7 virus. It is concluded that oncolytic viruses have been …
This article summarizes the preclinical toxicology studies of the most well studied oncolytic viruses, including Oncorine, Talimogene laherp …
37 results