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1996 2
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2,538 results

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Page 1
The Tetrafluoroethylene-Mediated Ring-Closing Metathesis: Enabling Unfavored Reactions.
Akiyama M, Amabe Y, Sugiyama M, Sugiyama K, Gatzenmeier T, Okazoe T. Akiyama M, et al. J Am Chem Soc. 2024 Nov 27;146(47):32550-32557. doi: 10.1021/jacs.4c10509. Epub 2024 Nov 13. J Am Chem Soc. 2024. PMID: 39538114
While ring-closing metathesis (RCM) is a powerful method for constructing medium and large cyclic alkenes, its application to the synthesis of heterocycles faces considerable limitations. ...In this system, a divinyloxyalkane and a TFE molecule are converted …
While ring-closing metathesis (RCM) is a powerful method for constructing medium and large cyclic alkenes, its applicat …
Ring-Closing Metathesis Approaches towards the Total Synthesis of Rhizoxins.
Liniger M, Neuhaus CM, Altmann KH. Liniger M, et al. Molecules. 2020 Oct 2;25(19):4527. doi: 10.3390/molecules25194527. Molecules. 2020. PMID: 33023218 Free PMC article.
A significant amount of work was expanded on the construction of the rhizoxin core macrocycle by ring-closing olefin metathesis (RCM) between C(9) and C(10), either directly or by using relay substrates, but in no case was ring-closure achieved. Macrocycle fo …
A significant amount of work was expanded on the construction of the rhizoxin core macrocycle by ring-closing olefin metath …
Ring-closing metathesis as a basis for the construction of aromatic compounds.
Donohoe TJ, Orr AJ, Bingham M. Donohoe TJ, et al. Angew Chem Int Ed Engl. 2006 Apr 21;45(17):2664-70. doi: 10.1002/anie.200503512. Angew Chem Int Ed Engl. 2006. PMID: 16548035 Review.
The use of metathesis, especially in the context of ring-closing metathesis (RCM) to form five- and six-membered rings, is widespread in organic chemistry today. ...
The use of metathesis, especially in the context of ring-closing metathesis (RCM) to form five- and six-membered …
Selective ring-rearrangement or ring-closing metathesis of bicyclo[3.2.1]octenes.
Semenova E , Lahtigui O , Scott SK , Albritton M , Abboud KA , Ghiviriga I , Roitberg AE , Grenning AJ . Semenova E , et al. Chem Commun (Camb). 2020 Oct 11;56(79):11779-11782. doi: 10.1039/d0cc04624h. Epub 2020 Sep 17. Chem Commun (Camb). 2020. PMID: 32940291
Explored was the competitive ring-closing metathesis vs. ring-rearrangement metathesis of bicyclo[3.2.1]octenes prepared by a simple and convergent synthesis from bicyclic alkylidenemalono-nitriles and allylic electrophiles. It was uncovered that ri …
Explored was the competitive ring-closing metathesis vs. ring-rearrangement metathesis of bicyclo[3.2.1]octenes …
AuCl(3) -Catalyzed Ring-Closing Carbonyl-Olefin Metathesis.
Wang R, Chen Y, Shu M, Zhao W, Tao M, Du C, Fu X, Li A, Lin Z. Wang R, et al. Chemistry. 2020 Feb 11;26(9):1941-1946. doi: 10.1002/chem.201905199. Epub 2020 Jan 30. Chemistry. 2020. PMID: 31867760
Compared with the ripeness of olefin metathesis, exploration of the construction of carbon-carbon double bonds through the catalytic carbonyl-olefin metathesis reaction remains stagnant and has received scant attention. Herein, a highly efficient AuCl(3) -catalyzed …
Compared with the ripeness of olefin metathesis, exploration of the construction of carbon-carbon double bonds through the catalytic …
Design and Synthesis of Polycycles, Heterocycles, and Macrocycles via Strategic Utilization of Ring-Closing Metathesis.
Kotha S, Meshram M, Dommaraju Y. Kotha S, et al. Chem Rec. 2018 Nov;18(11):1613-1632. doi: 10.1002/tcr.201800025. Epub 2018 Jun 19. Chem Rec. 2018. PMID: 29920922 Review.
In this perspective, we summarize new synthetic approaches for the construction of various polycyclic compounds involving ring-closing metathesis as a key step. In this regard, we used ring-closing metathesis in combination with other pop …
In this perspective, we summarize new synthetic approaches for the construction of various polycyclic compounds involving ring-clo …
A role for ring-closing metathesis in medicinal chemistry: mimicking secondary architectures in bioactive peptides.
Pérez de Vega MJ, García-Aranda MI, González-Muñiz R. Pérez de Vega MJ, et al. Med Res Rev. 2011 Sep;31(5):677-715. doi: 10.1002/med.20199. Epub 2010 Jan 14. Med Res Rev. 2011. PMID: 20077561 Review.
Synthetically versatile and easy to carry out, Ring-Closing Metathesis (RCM) constitutes an attractive chemical tool, easily amenable for multiple substrates in mild conditions. ...
Synthetically versatile and easy to carry out, Ring-Closing Metathesis (RCM) constitutes an attractive chemical tool, e …
Supported Catalysts Useful in Ring-Closing Metathesis, Cross Metathesis, and Ring-Opening Metathesis Polymerization.
Suriboot J, Bazzi HS, Bergbreiter DE. Suriboot J, et al. Polymers (Basel). 2016 Apr 12;8(4):140. doi: 10.3390/polym8040140. Polymers (Basel). 2016. PMID: 30979231 Free PMC article. Review.
This review highlights some of the history of efforts to address these problems, first discussing the problem in the context of reactions like ring-closing metathesis and cross metathesis catalysis used in the synthesis of low molecular weight compound …
This review highlights some of the history of efforts to address these problems, first discussing the problem in the context of reactions li …
Enamide-olefin ring-closing metathesis.
Kinderman SS, van Maarseveen JH, Schoemaker HE, Hiemstra H, Rutjes FP. Kinderman SS, et al. Org Lett. 2001 Jun 28;3(13):2045-8. doi: 10.1021/ol016013e. Org Lett. 2001. PMID: 11418045
[reaction: see text] The first examples of ring-closing metathesis reactions of olefin-containing enamides using ruthenium-based catalysts have been demonstrated. ...
[reaction: see text] The first examples of ring-closing metathesis reactions of olefin-containing enamides using ruthen …
Advances in Hydrocarbon Stapled Peptides via Ring-Closing Metathesis: Synthetic Strategies, Structural Diversity, and Therapeutic Applications.
Li L, Li R, Jiang Y, Chao J, Chen S, Liao H, Li X. Li L, et al. Chembiochem. 2025 Nov 27;26(23):e202500527. doi: 10.1002/cbic.202500527. Epub 2025 Oct 1. Chembiochem. 2025. PMID: 41031536 Review.
Among the various stapling methodologies, hydrocarbon stapling via ruthenium-catalyzed ring-closing metathesis remains the most widely adopted due to its robust chemical efficiency and synthetic compatibility with solid-phase peptide synthesis. ...The integra …
Among the various stapling methodologies, hydrocarbon stapling via ruthenium-catalyzed ring-closing metathesis remains …
2,538 results