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2004 411
2005 486
2006 588
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2012 1309
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33,069 results

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Page 1
Did you mean biomet (16,665 results)?
Cellular and Molecular Mechanisms of Metformin Action.
LaMoia TE, Shulman GI. LaMoia TE, et al. Endocr Rev. 2021 Jan 28;42(1):77-96. doi: 10.1210/endrev/bnaa023. Endocr Rev. 2021. PMID: 32897388 Free PMC article. Review.
However, despite decades of research, the mechanism by which metformin inhibits this process is still highly debated. A key reason for these discrepant effects is likely due to the inconsistency in dosage of metformin across studies. ...Here, we review the current l …
However, despite decades of research, the mechanism by which metformin inhibits this process is still highly debated. A key reason fo …
Human trials exploring anti-aging medicines.
Guarente L, Sinclair DA, Kroemer G. Guarente L, et al. Cell Metab. 2024 Feb 6;36(2):354-376. doi: 10.1016/j.cmet.2023.12.007. Epub 2024 Jan 4. Cell Metab. 2024. PMID: 38181790 Review.
Here, we summarize the current knowledge on eight promising drugs and natural compounds that have been tested in the clinic: metformin, NAD(+) precursors, glucagon-like peptide-1 receptor agonists, TORC1 inhibitors, spermidine, senolytics, probiotics, and anti-inflammatori …
Here, we summarize the current knowledge on eight promising drugs and natural compounds that have been tested in the clinic: metformin …
Metformin decelerates aging clock in male monkeys.
Yang Y, Lu X, Liu N, Ma S, Zhang H, Zhang Z, Yang K, Jiang M, Zheng Z, Qiao Y, Hu Q, Huang Y, Zhang Y, Xiong M, Liu L, Jiang X, Reddy P, Dong X, Xu F, Wang Q, Zhao Q, Lei J, Sun S, Jing Y, Li J, Cai Y, Fan Y, Yan K, Jing Y, Haghani A, Xing M, Zhang X, Zhu G, Song W, Horvath S, Rodriguez Esteban C, Song M, Wang S, Zhao G, Li W, Izpisua Belmonte JC, Qu J, Zhang W, Liu GH. Yang Y, et al. Cell. 2024 Oct 31;187(22):6358-6378.e29. doi: 10.1016/j.cell.2024.08.021. Epub 2024 Sep 12. Cell. 2024. PMID: 39270656
In a rigorous 40-month study, we evaluated the geroprotective effects of metformin on adult male cynomolgus monkeys, addressing a gap in primate aging research. The study encompassed a comprehensive suite of physiological, imaging, histological, and molecular evaluations, …
In a rigorous 40-month study, we evaluated the geroprotective effects of metformin on adult male cynomolgus monkeys, addressing a gap …
Metformin: from mechanisms of action to therapies.
Foretz M, Guigas B, Bertrand L, Pollak M, Viollet B. Foretz M, et al. Cell Metab. 2014 Dec 2;20(6):953-66. doi: 10.1016/j.cmet.2014.09.018. Epub 2014 Oct 30. Cell Metab. 2014. PMID: 25456737 Free article. Review.
Convincing data place energy metabolism at the center of metformin's mechanism of action in diabetes and may also be of importance in cardiovascular diseases and cancer. Metformin-induced activation of the energy-sensor AMPK is well documented, but may not ac …
Convincing data place energy metabolism at the center of metformin's mechanism of action in diabetes and may also be of import …
Metformin--mode of action and clinical implications for diabetes and cancer.
Pernicova I, Korbonits M. Pernicova I, et al. Nat Rev Endocrinol. 2014 Mar;10(3):143-56. doi: 10.1038/nrendo.2013.256. Epub 2014 Jan 7. Nat Rev Endocrinol. 2014. PMID: 24393785 Review.
Metformin has been the mainstay of therapy for diabetes mellitus for many years; however, the mechanistic aspects of metformin action remained ill-defined. ...The knowledge gained from dissecting the principal mechanisms by which metformin works can help us t …
Metformin has been the mainstay of therapy for diabetes mellitus for many years; however, the mechanistic aspects of metformin …
Benefits of Metformin in Attenuating the Hallmarks of Aging.
Kulkarni AS, Gubbi S, Barzilai N. Kulkarni AS, et al. Cell Metab. 2020 Jul 7;32(1):15-30. doi: 10.1016/j.cmet.2020.04.001. Epub 2020 Apr 24. Cell Metab. 2020. PMID: 32333835 Free PMC article. Review.
This review focuses on metformin's mechanisms in attenuating hallmarks of aging and their interconnectivity, by improving nutrient sensing, enhancing autophagy and intercellular communication, protecting against macromolecular damage, delaying stem cell aging, modul …
This review focuses on metformin's mechanisms in attenuating hallmarks of aging and their interconnectivity, by improving nutr …
Metformin: Mechanisms in Human Obesity and Weight Loss.
Yerevanian A, Soukas AA. Yerevanian A, et al. Curr Obes Rep. 2019 Jun;8(2):156-164. doi: 10.1007/s13679-019-00335-3. Curr Obes Rep. 2019. PMID: 30874963 Free PMC article. Review.
PURPOSE OF REVIEW: Metformin has multiple benefits for health beyond its anti-hyperglycemic properties. The purpose of this manuscript is to review the mechanisms that underlie metformin's effects on obesity. RECENT FINDINGS: Metformin is a first-line …
PURPOSE OF REVIEW: Metformin has multiple benefits for health beyond its anti-hyperglycemic properties. The purpose of this manuscrip …
Metformin: clinical use in type 2 diabetes.
Sanchez-Rangel E, Inzucchi SE. Sanchez-Rangel E, et al. Diabetologia. 2017 Sep;60(9):1586-1593. doi: 10.1007/s00125-017-4336-x. Epub 2017 Aug 2. Diabetologia. 2017. PMID: 28770321 Review.
Metformin is one of the most popular oral glucose-lowering medications, widely considered to be the optimal initial therapy for patients with type 2 diabetes mellitus. ...With no long-term studies comparing it against newer glucose-lowering drugs, some of which have more r …
Metformin is one of the most popular oral glucose-lowering medications, widely considered to be the optimal initial therapy for patie …
Metformin: historical overview.
Bailey CJ. Bailey CJ. Diabetologia. 2017 Sep;60(9):1566-1576. doi: 10.1007/s00125-017-4318-z. Epub 2017 Aug 3. Diabetologia. 2017. PMID: 28776081
Metformin's future was precarious, its reputation tarnished by association with other biguanides despite evident differences. ...Long-term cardiovascular benefits of metformin were identified by the UK Prospective Diabetes Study (UKPDS) in 1998, providing a n …
Metformin's future was precarious, its reputation tarnished by association with other biguanides despite evident differences. …
Metformin: Is it a drug for all reasons and diseases?
Triggle CR, Mohammed I, Bshesh K, Marei I, Ye K, Ding H, MacDonald R, Hollenberg MD, Hill MA. Triggle CR, et al. Metabolism. 2022 Aug;133:155223. doi: 10.1016/j.metabol.2022.155223. Epub 2022 May 29. Metabolism. 2022. PMID: 35640743 Free article. Review.
The objectives for this review are to: 1) evaluate the putative mechanism(s) of action of metformin; 2) analyze the controversial evidence for metformin's effectiveness in the treatment of diseases other than type 2 diabetes; 3) assess the reproducibility of …
The objectives for this review are to: 1) evaluate the putative mechanism(s) of action of metformin; 2) analyze the controversial evi …
33,069 results
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