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Page 1
Synthesis of RNA-cofactor conjugates and structural exploration of RNA recognition by an m6A RNA methyltransferase.
Meynier V, Iannazzo L, Catala M, Oerum S, Braud E, Atdjian C, Barraud P, Fonvielle M, Tisné C, Ethève-Quelquejeu M. Meynier V, et al. Nucleic Acids Res. 2022 Jun 10;50(10):5793-5806. doi: 10.1093/nar/gkac354. Nucleic Acids Res. 2022. PMID: 35580049 Free PMC article.
These compounds were used in crystallization assays with RlmJ, a bacterial m6A rRNA methyltransferase. Two crystal structures of RlmJ in complex with RNA-SAM conjugates were solved and revealed the RNA-specific recognition elements used by RlmJ to clamp the R …
These compounds were used in crystallization assays with RlmJ, a bacterial m6A rRNA methyltransferase. Two crystal structures of R …
Mechanistic insights into m6A RNA enzymes.
Lence T, Paolantoni C, Worpenberg L, Roignant JY. Lence T, et al. Biochim Biophys Acta Gene Regul Mech. 2019 Mar;1862(3):222-229. doi: 10.1016/j.bbagrm.2018.10.014. Epub 2018 Nov 3. Biochim Biophys Acta Gene Regul Mech. 2019. PMID: 30395944 Review.
Bisubstrate analogues as structural tools to investigate m6A methyltransferase active sites.
Oerum S, Catala M, Atdjian C, Brachet F, Ponchon L, Barraud P, Iannazzo L, Droogmans L, Braud E, Ethève-Quelquejeu M, Tisné C. Oerum S, et al. RNA Biol. 2019 Jun;16(6):798-808. doi: 10.1080/15476286.2019.1589360. Epub 2019 Mar 17. RNA Biol. 2019. PMID: 30879411 Free PMC article.
These proteins include, amongst others, RlmJ in E. coli and METLL3:METT14 and METTL16 in human. As a proof-of-concept, we here test the ability of the bisubstrate analogues to mimic the substrate:cofactor bound state during catalysis by studying their binding to RlmJ …
These proteins include, amongst others, RlmJ in E. coli and METLL3:METT14 and METTL16 in human. As a proof-of-concept, we here test t …
The last rRNA methyltransferase of E. coli revealed: the yhiR gene encodes adenine-N6 methyltransferase specific for modification of A2030 of 23S ribosomal RNA.
Golovina AY, Dzama MM, Osterman IA, Sergiev PV, Serebryakova MV, Bogdanov AA, Dontsova OA. Golovina AY, et al. RNA. 2012 Sep;18(9):1725-34. doi: 10.1261/rna.034207.112. Epub 2012 Jul 30. RNA. 2012. PMID: 22847818 Free PMC article.
YhiR prefers protein-free 23S rRNA to ribonucleoprotein particles containing only part of the 50S subunit proteins and does not methylate the assembled 50S subunit. We suggest renaming the yhiR gene to rlmJ according to the rRNA methyltransferase nomenclature …
YhiR prefers protein-free 23S rRNA to ribonucleoprotein particles containing only part of the 50S subunit proteins and does not methy …
Structural and functional insights into the molecular mechanism of rRNA m6A methyltransferase RlmJ.
Punekar AS, Liljeruhm J, Shepherd TR, Forster AC, Selmer M. Punekar AS, et al. Nucleic Acids Res. 2013 Nov;41(20):9537-48. doi: 10.1093/nar/gkt719. Epub 2013 Aug 13. Nucleic Acids Res. 2013. PMID: 23945937 Free PMC article.
RlmJ catalyzes the m(6)A2030 methylation of 23S rRNA during ribosome biogenesis in Escherichia coli. ...RlmJ displays a variant of the Rossmann-like methyltransferase (MTase) fold with an inserted helical subdomain. ...
RlmJ catalyzes the m(6)A2030 methylation of 23S rRNA during ribosome biogenesis in Escherichia coli. ...RlmJ displays a varian …
Purification, crystallization and preliminary X-ray diffraction analysis of the 23S rRNA methyltransferase RlmJ from Escherichia coli.
Punekar AS, Selmer M. Punekar AS, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Sep;69(Pt 9):1001-3. doi: 10.1107/S1744309113020289. Epub 2013 Aug 19. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013. PMID: 23989148 Free PMC article.
Methyltransferase RlmJ uses the cofactor S-adenosylmethionine to methylate the exocyclic nitrogen N6 of nucleotide A2030 in 23S rRNA during ribosome assembly in Escherichia coli. RlmJ with a C-terminal hexahistidine tag was overexpressed in E. coli and purified as a …
Methyltransferase RlmJ uses the cofactor S-adenosylmethionine to methylate the exocyclic nitrogen N6 of nucleotide A2030 in 23S rRNA …
Synthesis of Bisubstrate Analogues for RNA Methylation Studies using two Transition-Metal-Catalyzed Reactions.
Coelho D, Le Corre L, Bartosik K, Iannazzo L, Braud E, Ethève-Quelquejeu M. Coelho D, et al. Chemistry. 2023 Aug 4;29(44):e202301134. doi: 10.1002/chem.202301134. Epub 2023 Jul 6. Chemistry. 2023. PMID: 37222167
Docking studies of our molecules in the active site of the m6A ribosomal MTase RlmJ show that the use of triazole as a linker provides additional interactions and the presence of the alpha-amino acid chain stabilizes the bisubstrate. ...
Docking studies of our molecules in the active site of the m6A ribosomal MTase RlmJ show that the use of triazole as a linker provide …
N6-Methylated Adenosine in RNA: From Bacteria to Humans.
Sergiev PV, Golovina AY, Osterman IA, Nesterchuk MV, Sergeeva OV, Chugunova AA, Evfratov SA, Andreianova ES, Pletnev PI, Laptev IG, Petriukov KS, Navalayeu TI, Koteliansky VE, Bogdanov AA, Dontsova OA. Sergiev PV, et al. J Mol Biol. 2016 May 22;428(10 Pt B):2134-45. doi: 10.1016/j.jmb.2015.12.013. Epub 2015 Dec 19. J Mol Biol. 2016. PMID: 26707202 Review.
Genome-wide screen for Escherichia coli genes involved in repressing cell-to-cell transfer of non-conjugative plasmids.
Matsuda A, Kurono N, Kawano C, Shirota K, Hirabayashi A, Horino M, Etchuya R, Sobue R, Sasaki Y, Miyaue S, Sekoguchi A, Sugiura C, Shibata Y, Ito M, Ando T, Maeda S. Matsuda A, et al. Biochem Biophys Res Commun. 2012 Nov 30;428(4):445-50. doi: 10.1016/j.bbrc.2012.10.098. Epub 2012 Nov 3. Biochem Biophys Res Commun. 2012. PMID: 23131563
Two competence-gene homologues (ybaV and yhiR) were identified from among these genes. The presumed localizations of these 55 gene products were estimated to be 34 cytoplasmic proteins, 20 in or around the cell surface and 1 unknown location. ...
Two competence-gene homologues (ybaV and yhiR) were identified from among these genes. The presumed localizations of these 55 gene pr …