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The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis.
Bersuker K, Hendricks JM, Li Z, Magtanong L, Ford B, Tang PH, Roberts MA, Tong B, Maimone TJ, Zoncu R, Bassik MC, Nomura DK, Dixon SJ, Olzmann JA. Bersuker K, et al. Among authors: roberts ma. Nature. 2019 Nov;575(7784):688-692. doi: 10.1038/s41586-019-1705-2. Epub 2019 Oct 21. Nature. 2019. PMID: 31634900 Free PMC article.
Parallel CRISPR-Cas9 screens identify mechanisms of PLIN2 and lipid droplet regulation.
Roberts MA, Deol KK, Mathiowetz AJ, Lange M, Leto DE, Stevenson J, Hashemi SH, Morgens DW, Easter E, Heydari K, Nalls MA, Bassik MC, Kampmann M, Kopito RR, Faghri F, Olzmann JA. Roberts MA, et al. Dev Cell. 2023 Sep 25;58(18):1782-1800.e10. doi: 10.1016/j.devcel.2023.07.001. Epub 2023 Jul 25. Dev Cell. 2023. PMID: 37494933 Free article.
Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability.
Li Z, Ferguson L, Deol KK, Roberts MA, Magtanong L, Hendricks JM, Mousa GA, Kilinc S, Schaefer K, Wells JA, Bassik MC, Goga A, Dixon SJ, Ingolia NT, Olzmann JA. Li Z, et al. Among authors: roberts ma. Nat Chem Biol. 2022 Jul;18(7):751-761. doi: 10.1038/s41589-022-01033-3. Epub 2022 May 30. Nat Chem Biol. 2022. PMID: 35637349 Free PMC article.
Protocol for performing pooled CRISPR-Cas9 loss-of-function screens.
Mathiowetz AJ, Roberts MA, Morgens DW, Olzmann JA, Li Z. Mathiowetz AJ, et al. Among authors: roberts ma. STAR Protoc. 2023 Mar 30;4(2):102201. doi: 10.1016/j.xpro.2023.102201. Online ahead of print. STAR Protoc. 2023. PMID: 37000620 Free PMC article.
Protein Quality Control and Lipid Droplet Metabolism.
Roberts MA, Olzmann JA. Roberts MA, et al. Annu Rev Cell Dev Biol. 2020 Oct 6;36:115-139. doi: 10.1146/annurev-cellbio-031320-101827. Annu Rev Cell Dev Biol. 2020. PMID: 33021827 Free PMC article. Review.
VPS13A and VPS13C Influence Lipid Droplet Abundance.
Chen S, Roberts MA, Chen CY, Markmiller S, Wei HG, Yeo GW, Granneman JG, Olzmann JA, Ferro-Novick S. Chen S, et al. Among authors: roberts ma. Contact (Thousand Oaks). 2022 Sep 13;5:25152564221125613. doi: 10.1177/25152564221125613. eCollection 2022 Jan-Dec. Contact (Thousand Oaks). 2022. PMID: 36147729 Free PMC article.