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28 results
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Page 1
Targeting CD39 in Cancer Reveals an Extracellular ATP- and Inflammasome-Driven Tumor Immunity.
Li XY, Moesta AK, Xiao C, Nakamura K, Casey M, Zhang H, Madore J, Lepletier A, Aguilera AR, Sundarrajan A, Jacoberger-Foissac C, Wong C, Dela Cruz T, Welch M, Lerner AG, Spatola BN, Soros VB, Corbin J, Anderson AC, Effern M, Hölzel M, Robson SC, Johnston RL, Waddell N, Smith C, Bald T, Geetha N, Beers C, Teng MWL, Smyth MJ. Li XY, et al. Cancer Discov. 2019 Dec;9(12):1754-1773. doi: 10.1158/2159-8290.CD-19-0541. Epub 2019 Nov 7. Cancer Discov. 2019. PMID: 31699796 Free PMC article.
SIGNIFICANCE: Overall, these data describe a potent and novel mechanism of action of antibodies that block mouse or human CD39, triggering an eATP-P2X7-inflammasome-IL18 axis that reduces intratumor macrophage number, enhances intratumor T-cell effector function, overcomes anti-P …
SIGNIFICANCE: Overall, these data describe a potent and novel mechanism of action of antibodies that block mouse or human CD39, triggering a …
Atrial fibrillation in patients with cryptogenic stroke.
Gladstone DJ, Spring M, Dorian P, Panzov V, Thorpe KE, Hall J, Vaid H, O'Donnell M, Laupacis A, Côté R, Sharma M, Blakely JA, Shuaib A, Hachinski V, Coutts SB, Sahlas DJ, Teal P, Yip S, Spence JD, Buck B, Verreault S, Casaubon LK, Penn A, Selchen D, Jin A, Howse D, Mehdiratta M, Boyle K, Aviv R, Kapral MK, Mamdani M; EMBRACE Investigators and Coordinators. Gladstone DJ, et al. N Engl J Med. 2014 Jun 26;370(26):2467-77. doi: 10.1056/NEJMoa1311376. N Engl J Med. 2014. PMID: 24963566 Free article. Clinical Trial.
RESULTS: Atrial fibrillation lasting 30 seconds or longer was detected in 45 of 280 patients (16.1%) in the intervention group, as compared with 9 of 277 (3.2%) in the control group (absolute difference, 12.9 percentage points; 95% confidence interval [CI], 8.0 to 17.6; P& …
RESULTS: Atrial fibrillation lasting 30 seconds or longer was detected in 45 of 280 patients (16.1%) in the intervention group, as compared …
Model-Based and Model-Free Analyses of the Neural Correlates of Tongue Movements.
Sörös P, Schäfer S, Witt K. Sörös P, et al. Front Neurosci. 2020 Mar 24;14:226. doi: 10.3389/fnins.2020.00226. eCollection 2020. Front Neurosci. 2020. PMID: 32265635 Free PMC article.
Frontal (protrusion) tongue movements, highly overlearned movements related to speech production, showed less activity in the frontal and parietal lobes compared to horizontal (side to side) and vertical (elevation) movements and greater activity in the left frontal and temporal …
Frontal (protrusion) tongue movements, highly overlearned movements related to speech production, showed less activity in the frontal and pa …
Chronic noncancer pain is not associated with accelerated brain aging as assessed by structural magnetic resonance imaging in patients treated in specialized outpatient clinics.
Sörös P, Bantel C. Sörös P, et al. Pain. 2020 Mar;161(3):641-650. doi: 10.1097/j.pain.0000000000001756. Pain. 2020. PMID: 31764393
This study provided no evidence for the hypothesis that chronic pain is associated with accelerated brain aging (Welch t test, P = 0.74, Cohen's d = 0.061). A Bayesian independent-samples t test indicated moderate evidence in favor of the null hypothesis (BF01 = 4.8 …
This study provided no evidence for the hypothesis that chronic pain is associated with accelerated brain aging (Welch t test, P = 0. …
[Phantom pain after eye enucleation].
Gerding H, Vo O, Husstedt IW, Evers S, Sörös P. Gerding H, et al. Ophthalmologe. 2003 Nov;100(11):943-9. doi: 10.1007/s00347-003-0828-9. Ophthalmologe. 2003. PMID: 14669029 German.
Perioperative pain symptoms (ocular pain [OP], preoperative and postoperative headache) were reported with a higher proportion (each p<0.0025) in patients with PEP compared to those not affected by PEP. ...
Perioperative pain symptoms (ocular pain [OP], preoperative and postoperative headache) were reported with a higher proportion (each p
Atrial premature beats predict atrial fibrillation in cryptogenic stroke: results from the EMBRACE trial.
Gladstone DJ, Dorian P, Spring M, Panzov V, Mamdani M, Healey JS, Thorpe KE; EMBRACE Steering Committee and Investigators. Gladstone DJ, et al. Stroke. 2015 Apr;46(4):936-41. doi: 10.1161/STROKEAHA.115.008714. Epub 2015 Feb 19. Stroke. 2015. PMID: 25700289 Clinical Trial.
RESULTS: Among 237 participants, the median baseline Holter APB count/24 h was 629 (interquartile range, 142-1973) among those who subsequently had AF detected versus 45 (interquartile range, 14-250) in those without AF (P<0.001). APB count was the only significant pred …
RESULTS: Among 237 participants, the median baseline Holter APB count/24 h was 629 (interquartile range, 142-1973) among those who subsequen …
The 24-hour average concentration of cortisol is elevated in obese African-American youth with type 2 diabetes.
Gumus Balikcioglu P, Balikcioglu M, Soros A, Chalew S. Gumus Balikcioglu P, et al. J Diabetes Complications. 2021 Jul;35(7):107933. doi: 10.1016/j.jdiacomp.2021.107933. Epub 2021 Apr 16. J Diabetes Complications. 2021. PMID: 33902997
T2D patients had slightly lower BMI z-score (2.25 0.36 versus 2.58 0.16, p = 0.0429). IC-cortisol (5.70 1.8 mug/dl vs 4.18 1.07 mug/dl, p = 0.0481) was higher and IC-C-peptide (2.33 0.89 ng/ml vs 4.36 1.12 ng/ml, p = 0.001) lower in T2D. There were no differe …
T2D patients had slightly lower BMI z-score (2.25 0.36 versus 2.58 0.16, p = 0.0429). IC-cortisol (5.70 1.8 mug/dl vs 4.18 1.07 mug/d …
Inattention Predicts Increased Thickness of Left Occipital Cortex in Men with Attention-Deficit/Hyperactivity Disorder.
Sörös P, Bachmann K, Lam AP, Kanat M, Hoxhaj E, Matthies S, Feige B, Müller HHO, Thiel C, Philipsen A. Sörös P, et al. Front Psychiatry. 2017 Sep 13;8:170. doi: 10.3389/fpsyt.2017.00170. eCollection 2017. Front Psychiatry. 2017. PMID: 28955255 Free PMC article.

RESULTS: Linear regression identified an area in the left occipital cortex of men, covering parts of the middle occipital sulcus and gyrus, in which the score on the CAARS inattention subscale predicted increased mean cortical thickness [F(1,27) = 26.27, p < 0.001, adju

RESULTS: Linear regression identified an area in the left occipital cortex of men, covering parts of the middle occipital sulcus and gyrus, …
Impaired insulin sensitivity and elevated ectopic fat in healthy obese vs. nonobese prepubertal children.
Bennett B, Larson-Meyer DE, Ravussin E, Volaufova J, Soros A, Cefalu WT, Chalew S, Gordon S, Smith SR, Newcomer BR, Goran M, Sothern M. Bennett B, et al. Obesity (Silver Spring). 2012 Feb;20(2):371-5. doi: 10.1038/oby.2011.264. Epub 2011 Aug 25. Obesity (Silver Spring). 2012. PMID: 21869763 Free PMC article.
Insulin sensitivity was assessed by both a frequently sampled intravenous glucose tolerance test (S(i)) and the homeostatic model assessment of insulin resistance (HOMA(IR)). ...We also examined serum lipids (total cholesterol, triglycerides, high-density lipoprotein chole …
Insulin sensitivity was assessed by both a frequently sampled intravenous glucose tolerance test (S(i)) and the homeostatic model ass …
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