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Insulin as a weapon.
Robinson SD, Safavi-Hemami H. Robinson SD, et al. Toxicon. 2016 Dec 1;123:56-61. doi: 10.1016/j.toxicon.2016.10.010. Epub 2016 Oct 21. Toxicon. 2016. PMID: 27777069 Review.
The discovery of insulin and its use for the treatment of diabetes is undoubtedly one of the true successes of modern medicine. Injectable insulin would prove the first effective treatment for a previously incurable and usually fatal disease. ...
The discovery of insulin and its use for the treatment of diabetes is undoubtedly one of the true successes of modern medicine. Injec …
A structurally minimized yet fully active insulin based on cone-snail venom insulin principles.
Xiong X, Menting JG, Disotuar MM, Smith NA, Delaine CA, Ghabash G, Agrawal R, Wang X, He X, Fisher SJ, MacRaild CA, Norton RS, Gajewiak J, Forbes BE, Smith BJ, Safavi-Hemami H, Olivera B, Lawrence MC, Chou DH. Xiong X, et al. Nat Struct Mol Biol. 2020 Jul;27(7):615-624. doi: 10.1038/s41594-020-0430-8. Epub 2020 Jun 1. Nat Struct Mol Biol. 2020. PMID: 32483339 Free PMC article.
Recently, we described a monomeric, insulin-like peptide in cone-snail venom with moderate human insulin-like bioactivity. Here, with insights from structural biology studies, we report the development of mini-Ins-a human des-octapeptide insulin analog-as a s …
Recently, we described a monomeric, insulin-like peptide in cone-snail venom with moderate human insulin-like bioactivity. Her …
Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor.
Ahorukomeye P, Disotuar MM, Gajewiak J, Karanth S, Watkins M, Robinson SD, Flórez Salcedo P, Smith NA, Smith BJ, Schlegel A, Forbes BE, Olivera B, Hung-Chieh Chou D, Safavi-Hemami H. Ahorukomeye P, et al. Elife. 2019 Feb 12;8:e41574. doi: 10.7554/eLife.41574. Elife. 2019. PMID: 30747102 Free PMC article.
The fish-hunting marine cone snail Conus geographus uses a specialized venom insulin to induce hypoglycemic shock in its prey. We recently showed that this venom insulin, Con-Ins G1, has unique characteristics relevant to the design of new insulin therapeutic …
The fish-hunting marine cone snail Conus geographus uses a specialized venom insulin to induce hypoglycemic shock in its prey. We rec …
Venom peptides as pharmacological tools and therapeutics for diabetes.
Robinson SD, Safavi-Hemami H. Robinson SD, et al. Neuropharmacology. 2017 Dec;127:79-86. doi: 10.1016/j.neuropharm.2017.07.001. Epub 2017 Jul 5. Neuropharmacology. 2017. PMID: 28689026 Review.
Diabetes mellitus is a chronic disease caused by a deficiency in production of insulin by the beta cells of the pancreas (type 1 diabetes, T1D), or by partial deficiency of insulin production and the ineffectiveness of the insulin produced (type 2 diabetes, T …
Diabetes mellitus is a chronic disease caused by a deficiency in production of insulin by the beta cells of the pancreas (type 1 diab …
A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin.
Menting JG, Gajewiak J, MacRaild CA, Chou DH, Disotuar MM, Smith NA, Miller C, Erchegyi J, Rivier JE, Olivera BM, Forbes BE, Smith BJ, Norton RS, Safavi-Hemami H, Lawrence MC. Menting JG, et al. Nat Struct Mol Biol. 2016 Oct;23(10):916-920. doi: 10.1038/nsmb.3292. Epub 2016 Sep 12. Nat Struct Mol Biol. 2016. PMID: 27617429
One such insulin, Conus geographus G1 (Con-Ins G1), is the smallest known insulin found in nature and lacks the C-terminal segment of the B chain that, in human insulin, mediates engagement of the insulin receptor and assembly of the hormone's h …
One such insulin, Conus geographus G1 (Con-Ins G1), is the smallest known insulin found in nature and lacks the C-terminal seg …
Transcriptomic Profiling Reveals Extraordinary Diversity of Venom Peptides in Unexplored Predatory Gastropods of the Genus Clavus.
Lu A, Watkins M, Li Q, Robinson SD, Concepcion GP, Yandell M, Weng Z, Olivera BM, Safavi-Hemami H, Fedosov AE. Lu A, et al. Genome Biol Evol. 2020 May 1;12(5):684-700. doi: 10.1093/gbe/evaa083. Genome Biol Evol. 2020. PMID: 32333764 Free PMC article.
However, convincing homology with known groups of Conus toxins was only detected for very few toxin families. Among these are Clavus counterparts of Conus venom insulins (drillinsulins), porins (drilliporins), and highly diversified lectins (drillilectins). ...
However, convincing homology with known groups of Conus toxins was only detected for very few toxin families. Among these are Clavus counter …
Venom Insulins of Cone Snails Diversify Rapidly and Track Prey Taxa.
Safavi-Hemami H, Lu A, Li Q, Fedosov AE, Biggs J, Showers Corneli P, Seger J, Yandell M, Olivera BM. Safavi-Hemami H, et al. Mol Biol Evol. 2016 Nov;33(11):2924-2934. doi: 10.1093/molbev/msw174. Epub 2016 Aug 14. Mol Biol Evol. 2016. PMID: 27524826 Free PMC article.
Cone snails express a highly conserved insulin in their nerve ring; presumably this conventional signaling insulin is finely tuned to the Conus insulin receptor, which also evolves very slowly. ...Prey insulin receptors may often be constrained in ways …
Cone snails express a highly conserved insulin in their nerve ring; presumably this conventional signaling insulin is finely t …
Specialized insulin is used for chemical warfare by fish-hunting cone snails.
Safavi-Hemami H, Gajewiak J, Karanth S, Robinson SD, Ueberheide B, Douglass AD, Schlegel A, Imperial JS, Watkins M, Bandyopadhyay PK, Yandell M, Li Q, Purcell AW, Norton RS, Ellgaard L, Olivera BM. Safavi-Hemami H, et al. Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1743-8. doi: 10.1073/pnas.1423857112. Epub 2015 Jan 20. Proc Natl Acad Sci U S A. 2015. PMID: 25605914 Free PMC article.
Two fish-hunting cone snails, Conus geographus and Conus tulipa, have evolved specialized insulins that are expressed as major components of their venoms. These insulins are distinctive in having much greater similarity to fish insulins than to the molluscan …
Two fish-hunting cone snails, Conus geographus and Conus tulipa, have evolved specialized insulins that are expressed as major compon …
A prominent role of PDIA6 in processing of misfolded proinsulin.
Gorasia DG, Dudek NL, Safavi-Hemami H, Perez RA, Schittenhelm RB, Saunders PM, Wee S, Mangum JE, Hubbard MJ, Purcell AW. Gorasia DG, et al. Biochim Biophys Acta. 2016 Jun;1864(6):715-723. doi: 10.1016/j.bbapap.2016.03.002. Epub 2016 Mar 3. Biochim Biophys Acta. 2016. PMID: 26947243
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