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Page 1
Salidroside in the Treatment of NAFLD/NASH.
Qu B, Liu X, Liang Y, Zheng K, Zhang C, Lu L. Qu B, et al. Chem Biodivers. 2022 Dec;19(12):e202200401. doi: 10.1002/cbdv.202200401. Epub 2022 Nov 14. Chem Biodivers. 2022. PMID: 36210339 Review.
Apart from bariatric surgery and lifestyle changes, officially approved drug therapy for NAFLD/NASH treatment is lacking. Salidroside (SDS) is a phenolic compound extensively distributed in the tubers of Rhodiola plants, which possesses many significant biological activiti …
Apart from bariatric surgery and lifestyle changes, officially approved drug therapy for NAFLD/NASH treatment is lacking. Salidroside
Salidroside inhibits MAPK, NF-kappaB, and STAT3 pathways in psoriasis-associated oxidative stress via SIRT1 activation.
Xu F, Xu J, Xiong X, Deng Y. Xu F, et al. Redox Rep. 2019 Dec;24(1):70-74. doi: 10.1080/13510002.2019.1658377. Redox Rep. 2019. PMID: 31495284 Free PMC article. Review.
Objectives: To unveil the role of SIRT1 in limiting oxidative stress in psoriasis and to further discuss the therapeutic prospects of salidroside in psoriasis. Methods: Literature from 2002 to 2019 was searched with "psoriasis", "oxidative stress", "SIRT1", "salidroside
Objectives: To unveil the role of SIRT1 in limiting oxidative stress in psoriasis and to further discuss the therapeutic prospects of sal
Salidroside alleviates cognitive impairment by inhibiting ferroptosis via activation of the Nrf2/GPX4 axis in SAMP8 mice.
Yang S, Wang L, Zeng Y, Wang Y, Pei T, Xie Z, Xiong Q, Wei H, Li W, Li J, Su Q, Wei D, Cheng W. Yang S, et al. Phytomedicine. 2023 Jun;114:154762. doi: 10.1016/j.phymed.2023.154762. Epub 2023 Mar 14. Phytomedicine. 2023. PMID: 36965372 Free article.
Ferroptosis and adaptive immunity have been proven to contribute to AD pathogenesis. Salidroside exhibits neuroprotective and immunomodulatory effects. However, the underlying mechanisms linking salidroside, ferroptosis, and adaptive immunity in AD remain uncertain. …
Ferroptosis and adaptive immunity have been proven to contribute to AD pathogenesis. Salidroside exhibits neuroprotective and immunom …
Salidroside stimulates the Sirt1/PGC-1alpha axis and ameliorates diabetic nephropathy in mice.
Xue H, Li P, Luo Y, Wu C, Liu Y, Qin X, Huang X, Sun C. Xue H, et al. Phytomedicine. 2019 Feb 15;54:240-247. doi: 10.1016/j.phymed.2018.10.031. Epub 2018 Oct 25. Phytomedicine. 2019. PMID: 30668374
However, whether salidroside plays a beneficial role in diabetic nephropathy is still unclear. ...Morphological analysis indicated that salidroside improves renal structures in diabetic nephropathy. The decreases in nephrin and podocin expression were markedly rever …
However, whether salidroside plays a beneficial role in diabetic nephropathy is still unclear. ...Morphological analysis indicated th …
Salidroside - Can it be a Multifunctional Drug?
Magani SKJ, Mupparthi SD, Gollapalli BP, Shukla D, Tiwari AK, Gorantala J, Yarla NS, Tantravahi S. Magani SKJ, et al. Curr Drug Metab. 2020;21(7):512-524. doi: 10.2174/1389200221666200610172105. Curr Drug Metab. 2020. PMID: 32520682 Review.
BACKGROUND: Salidroside is a glucoside of tyrosol found mostly in the roots of Rhodiola spp. ...This review mostly concentrates on the metabolism, biological activities and molecular pathways related to various pharmacological activities of salidroside. CONCLUSION: …
BACKGROUND: Salidroside is a glucoside of tyrosol found mostly in the roots of Rhodiola spp. ...This review mostly concentrates on th …
Salidroside induces apoptosis and protective autophagy in human gastric cancer AGS cells through the PI3K/Akt/mTOR pathway.
Rong L, Li Z, Leng X, Li H, Ma Y, Chen Y, Song F. Rong L, et al. Biomed Pharmacother. 2020 Feb;122:109726. doi: 10.1016/j.biopha.2019.109726. Epub 2019 Dec 30. Biomed Pharmacother. 2020. PMID: 31918283 Free article.
Additionally, we found that salidroside decreased the phosphorylation of PI3K and Akt and that pretreatment with the PI3K/Akt agonist IGF-1 could weaken the proapoptotic effect of salidroside. ...Furthermore, treatment with the autophagy inhibitor chloroquine enhanc …
Additionally, we found that salidroside decreased the phosphorylation of PI3K and Akt and that pretreatment with the PI3K/Akt agonist …
Salidroside alleviates ulcerative colitis via inhibiting macrophage pyroptosis and repairing the dysbacteriosis-associated Th17/Treg imbalance.
Liu X, Zhou M, Dai Z, Luo S, Shi Y, He Z, Chen Y. Liu X, et al. Phytother Res. 2023 Feb;37(2):367-382. doi: 10.1002/ptr.7636. Epub 2022 Nov 4. Phytother Res. 2023. PMID: 36331009
Moreover, the TREM1 inhibitor weakened the effect of salidroside on BMDMs pyroptosis, whereas salidroside still could downregulate TREM1 when NLRP3 was inhibited. ...Clearance of the gut flora blocked the benefit of salidroside on colonic inflammation and Th1 …
Moreover, the TREM1 inhibitor weakened the effect of salidroside on BMDMs pyroptosis, whereas salidroside still could downregu …
Salidroside prevents PM2.5-induced BEAS-2B cell apoptosis via SIRT1-dependent regulation of ROS and mitochondrial function.
Shan H, Li X, Ouyang C, Ke H, Yu X, Tan J, Chen J, Wang C, Zhang L, Tang Y, Yu L, Li W. Shan H, et al. Ecotoxicol Environ Saf. 2022 Feb;231:113170. doi: 10.1016/j.ecoenv.2022.113170. Epub 2022 Jan 10. Ecotoxicol Environ Saf. 2022. PMID: 35026589 Free article.
It has been closely linked to increased morbidity of bronchial asthma and lung cancer worldwide. Salidroside (Sal), an active component extracted from Rhodiola rosea, has been reported to ameliorate the progression of asthma. However, there are few studies on the protectiv …
It has been closely linked to increased morbidity of bronchial asthma and lung cancer worldwide. Salidroside (Sal), an active compone …
Salidroside: A review of its recent advances in synthetic pathways and pharmacological properties.
Zhang X, Xie L, Long J, Xie Q, Zheng Y, Liu K, Li X. Zhang X, et al. Chem Biol Interact. 2021 Apr 25;339:109268. doi: 10.1016/j.cbi.2020.109268. Epub 2021 Feb 20. Chem Biol Interact. 2021. PMID: 33617801 Review.
Salidroside has been identified as one of the most potent compounds isolated from various Rhodiola plants, which have been used for a long time as adaptogens in traditional Chinese medicine. However, due to the severe growing environment of herbal medicine and large-scale
Salidroside has been identified as one of the most potent compounds isolated from various Rhodiola plants, which have been used for a
Salidroside attenuates neuroinflammation and improves functional recovery after spinal cord injury through microglia polarization regulation.
Wang C, Wang Q, Lou Y, Xu J, Feng Z, Chen Y, Tang Q, Zheng G, Zhang Z, Wu Y, Tian N, Zhou Y, Xu H, Zhang X. Wang C, et al. J Cell Mol Med. 2018 Feb;22(2):1148-1166. doi: 10.1111/jcmm.13368. Epub 2017 Nov 17. J Cell Mol Med. 2018. PMID: 29148269 Free PMC article.
Neuroinflammation is the major pathogenesis of SCI secondary injury and considered to be the therapeutic target of SCI. Salidroside (Sal) has been reported to exert anti-inflammatory effects in airway, adipose and myocardial tissue; however, the role of Sal in SCI therapeu …
Neuroinflammation is the major pathogenesis of SCI secondary injury and considered to be the therapeutic target of SCI. Salidroside ( …
1,077 results