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Page 1
Combining Ketamine Infusions and Written Exposure Therapy for Chronic PTSD: An Open-Label Trial.
Feder A, Brown O, Rutter SB, Cahn L, Overbey JR, Seeley SH, Yu A, Bonanno PA, Fremont RA, Delgado AA, Jha MK, Costi S, Yehuda R, Schiller D, Pietrzak RH, Charney DS, Sloan DM, Murrough JW. Feder A, et al. Among authors: costi s. J Clin Psychiatry. 2025 Apr 2;86(2):24m15622. doi: 10.4088/JCP.24m15622. J Clin Psychiatry. 2025. PMID: 40215385 Free PMC article. Clinical Trial.
Effects of the KCNQ (Kv7) Channel Opener Ezogabine on Resting-State Functional Connectivity of Striatal Brain Reward Regions, Depression, and Anhedonia in Major Depressive Disorder: Results From a Randomized Controlled Trial.
Chowdhury A, Boukezzi S, Costi S, Hameed S, Jacob Y, Salas R, Iosifescu DV, Han MH, Swann A, Mathew SJ, Morris L, Murrough JW. Chowdhury A, et al. Among authors: costi s. Biol Psychiatry. 2025 Oct 1;98(7):568-577. doi: 10.1016/j.biopsych.2025.02.897. Epub 2025 Mar 4. Biol Psychiatry. 2025. PMID: 40049579 Free PMC article. Clinical Trial.
Ketamine vs Electroconvulsive Therapy for Treatment-Resistant Depression: A Secondary Analysis of a Randomized Clinical Trial.
Jha MK, Wilkinson ST, Krishnan K, Collins KA, Sanacora G, Murrough J, Goes F, Altinay M, Aloysi A, Asghar-Ali A, Barnett B, Chang L, Costi S, Malone D, Nikayin S, Nissen SE, Ostroff R, Reti I, Wolski K, Wang D, Hu B, Mathew SJ, Anand A. Jha MK, et al. Among authors: costi s. JAMA Netw Open. 2024 Jun 3;7(6):e2417786. doi: 10.1001/jamanetworkopen.2024.17786. JAMA Netw Open. 2024. PMID: 38916891 Free PMC article. Clinical Trial.
Circulating myeloid-derived MMP8 in stress susceptibility and depression.
Cathomas F, Lin HY, Chan KL, Li L, Parise LF, Alvarez J, Durand-de Cuttoli R, Aubry AV, Muhareb S, Desland F, Shimo Y, Ramakrishnan A, Estill M, Ferrer-Pérez C, Parise EM, Wilk CM, Kaster MP, Wang J, Sowa A, Janssen WG, Costi S, Rahman A, Fernandez N, Campbell M, Swirski FK, Nestler EJ, Shen L, Merad M, Murrough JW, Russo SJ. Cathomas F, et al. Among authors: costi s. Nature. 2024 Feb;626(8001):1108-1115. doi: 10.1038/s41586-023-07015-2. Epub 2024 Feb 7. Nature. 2024. PMID: 38326622 Free PMC article.
Social stress induces autoimmune responses against the brain.
Shimo Y, Cathomas F, Lin HY, Chan KL, Parise LF, Li L, Ferrer-Pérez C, Muhareb S, Costi S, Murrough JW, Russo SJ. Shimo Y, et al. Among authors: costi s. Proc Natl Acad Sci U S A. 2023 Dec 5;120(49):e2305778120. doi: 10.1073/pnas.2305778120. Epub 2023 Nov 27. Proc Natl Acad Sci U S A. 2023. PMID: 38011565 Free PMC article.
Ketamine for Major Depressive Disorder.
Costi S. Costi S. Curr Top Behav Neurosci. 2024;66:131-147. doi: 10.1007/7854_2023_453. Curr Top Behav Neurosci. 2024. PMID: 37922100 Review.
A Randomized Controlled Trial of Repeated Ketamine Administration for Chronic Posttraumatic Stress Disorder.
Feder A, Costi S, Rutter SB, Collins AB, Govindarajulu U, Jha MK, Horn SR, Kautz M, Corniquel M, Collins KA, Bevilacqua L, Glasgow AM, Brallier J, Pietrzak RH, Murrough JW, Charney DS. Feder A, et al. Among authors: costi s. Focus (Am Psychiatr Publ). 2023 Jul;21(3):296-305. doi: 10.1176/appi.focus.23021014. Epub 2023 Jun 28. Focus (Am Psychiatr Publ). 2023. PMID: 37404970 Free PMC article.
Ketamine versus ECT for Nonpsychotic Treatment-Resistant Major Depression.
Anand A, Mathew SJ, Sanacora G, Murrough JW, Goes FS, Altinay M, Aloysi AS, Asghar-Ali AA, Barnett BS, Chang LC, Collins KA, Costi S, Iqbal S, Jha MK, Krishnan K, Malone DA, Nikayin S, Nissen SE, Ostroff RB, Reti IM, Wilkinson ST, Wolski K, Hu B. Anand A, et al. Among authors: costi s. N Engl J Med. 2023 Jun 22;388(25):2315-2325. doi: 10.1056/NEJMoa2302399. Epub 2023 May 24. N Engl J Med. 2023. PMID: 37224232 Clinical Trial.
Peripheral immune-derived matrix metalloproteinase promotes stress susceptibility.
Cathomas F, Lin HY, Chan KL, Li L, Durand-de Cuttoli R, Parise LF, Aubry AV, Muhareb S, Desland F, Shimo Y, Ramakrishnan A, Estill M, Ferrer-Pérez C, Parise EM, Wang J, Sowa A, Janssen WG, Costi S, Rahman A, Fernandez N, Swirski FK, Nestler EJ, Shen L, Merad M, Murrough JW, Russo SJ. Cathomas F, et al. Among authors: costi s. Res Sq [Preprint]. 2023 Jan 30:rs.3.rs-1647827. doi: 10.21203/rs.3.rs-1647827/v1. Res Sq. 2023. Update in: Nature. 2024 Feb;626(8001):1108-1115. doi: 10.1038/s41586-023-07015-2. PMID: 36778505 Free PMC article. Updated. Preprint.
Ketamine as a prophylactic resilience-enhancing agent.
Evers AG, Murrough JW, Charney DS, Costi S. Evers AG, et al. Among authors: costi s. Front Psychiatry. 2022 Jul 28;13:833259. doi: 10.3389/fpsyt.2022.833259. eCollection 2022. Front Psychiatry. 2022. PMID: 35966469 Free PMC article. Review.
Neuroimaging correlates and predictors of response to repeated-dose intravenous ketamine in PTSD: preliminary evidence.
Norbury A, Rutter SB, Collins AB, Costi S, Jha MK, Horn SR, Kautz M, Corniquel M, Collins KA, Glasgow AM, Brallier J, Shin LM, Charney DS, Murrough JW, Feder A. Norbury A, et al. Among authors: costi s. Neuropsychopharmacology. 2021 Dec;46(13):2266-2277. doi: 10.1038/s41386-021-01104-4. Epub 2021 Jul 31. Neuropsychopharmacology. 2021. PMID: 34333555 Free PMC article. Clinical Trial.
Impact of the KCNQ2/3 Channel Opener Ezogabine on Reward Circuit Activity and Clinical Symptoms in Depression: Results From a Randomized Controlled Trial.
Costi S, Morris LS, Kirkwood KA, Hoch M, Corniquel M, Vo-Le B, Iqbal T, Chadha N, Pizzagalli DA, Whitton A, Bevilacqua L, Jha MK, Ursu S, Swann AC, Collins KA, Salas R, Bagiella E, Parides MK, Stern ER, Iosifescu DV, Han MH, Mathew SJ, Murrough JW. Costi S, et al. Am J Psychiatry. 2021 May 1;178(5):437-446. doi: 10.1176/appi.ajp.2020.20050653. Epub 2021 Mar 3. Am J Psychiatry. 2021. PMID: 33653118 Free PMC article. Clinical Trial.
A Randomized Controlled Trial of Repeated Ketamine Administration for Chronic Posttraumatic Stress Disorder.
Feder A, Costi S, Rutter SB, Collins AB, Govindarajulu U, Jha MK, Horn SR, Kautz M, Corniquel M, Collins KA, Bevilacqua L, Glasgow AM, Brallier J, Pietrzak RH, Murrough JW, Charney DS. Feder A, et al. Among authors: costi s. Am J Psychiatry. 2021 Feb 1;178(2):193-202. doi: 10.1176/appi.ajp.2020.20050596. Epub 2021 Jan 5. Am J Psychiatry. 2021. PMID: 33397139 Clinical Trial.
Lithium continuation therapy following ketamine in patients with treatment resistant unipolar depression: a randomized controlled trial.
Costi S, Soleimani L, Glasgow A, Brallier J, Spivack J, Schwartz J, Levitch CF, Richards S, Hoch M, Stade EC, Welch A, Collins KA, Feder A, Iosifescu DV, Charney DS, Murrough JW. Costi S, et al. Neuropsychopharmacology. 2019 Sep;44(10):1812-1819. doi: 10.1038/s41386-019-0365-0. Epub 2019 Mar 11. Neuropsychopharmacology. 2019. PMID: 30858518 Free PMC article. Clinical Trial.
Effects of the KCNQ channel opener ezogabine on functional connectivity of the ventral striatum and clinical symptoms in patients with major depressive disorder.
Tan A, Costi S, Morris LS, Van Dam NT, Kautz M, Whitton AE, Friedman AK, Collins KA, Ahle G, Chadha N, Do B, Pizzagalli DA, Iosifescu DV, Nestler EJ, Han MH, Murrough JW. Tan A, et al. Among authors: costi s. Mol Psychiatry. 2020 Jun;25(6):1323-1333. doi: 10.1038/s41380-018-0283-2. Epub 2018 Nov 1. Mol Psychiatry. 2020. PMID: 30385872 Free PMC article. Clinical Trial.