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Olfactomedin 4 associates with expression of differentiation markers but not with properties of cancer stemness, EMT nor metastatic spread in colorectal cancer.
Jaitner S, Pretzsch E, Neumann J, Schäffauer A, Schiemann M, Angele M, Kumbrink J, Schwitalla S, Greten FR, Brandl L, Klauschen F, Horst D, Kirchner T, Jung A. Jaitner S, et al. Among authors: schwitalla s. J Pathol Clin Res. 2023 Jan;9(1):73-85. doi: 10.1002/cjp2.300. Epub 2022 Nov 8. J Pathol Clin Res. 2023. PMID: 36349502 Free PMC article.
LIN28 cooperates with WNT signaling to drive invasive intestinal and colorectal adenocarcinoma in mice and humans.
Tu HC, Schwitalla S, Qian Z, LaPier GS, Yermalovich A, Ku YC, Chen SC, Viswanathan SR, Zhu H, Nishihara R, Inamura K, Kim SA, Morikawa T, Mima K, Sukawa Y, Yang J, Meredith G, Fuchs CS, Ogino S, Daley GQ. Tu HC, et al. Among authors: schwitalla s. Genes Dev. 2015 May 15;29(10):1074-86. doi: 10.1101/gad.256693.114. Epub 2015 May 8. Genes Dev. 2015. PMID: 25956904 Free PMC article.
Corrigendum. IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis.
Rokavec M, Öner MG, Li H, Jackstadt R, Jiang L, Lodygin D, Kaller M, Horst D, Ziegler PK, Schwitalla S, Slotta-Huspenina J, Bader FG, Greten FR, Hermeking H. Rokavec M, et al. Among authors: schwitalla s. J Clin Invest. 2015 Mar 2;125(3):1362. doi: 10.1172/JCI81340. Epub 2015 Mar 2. J Clin Invest. 2015. PMID: 25729853 Free PMC article. No abstract available.
High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity.
Schulz MD, Atay C, Heringer J, Romrig FK, Schwitalla S, Aydin B, Ziegler PK, Varga J, Reindl W, Pommerenke C, Salinas-Riester G, Böck A, Alpert C, Blaut M, Polson SC, Brandl L, Kirchner T, Greten FR, Polson SW, Arkan MC. Schulz MD, et al. Among authors: schwitalla s. Nature. 2014 Oct 23;514(7523):508-12. doi: 10.1038/nature13398. Epub 2014 Aug 31. Nature. 2014. PMID: 25174708 Free PMC article.
ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation.
Myant KB, Cammareri P, McGhee EJ, Ridgway RA, Huels DJ, Cordero JB, Schwitalla S, Kalna G, Ogg EL, Athineos D, Timpson P, Vidal M, Murray GI, Greten FR, Anderson KI, Sansom OJ. Myant KB, et al. Among authors: schwitalla s. Cell Stem Cell. 2013 Jun 6;12(6):761-73. doi: 10.1016/j.stem.2013.04.006. Epub 2013 May 9. Cell Stem Cell. 2013. PMID: 23665120 Free PMC article.
Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties.
Schwitalla S, Fingerle AA, Cammareri P, Nebelsiek T, Göktuna SI, Ziegler PK, Canli O, Heijmans J, Huels DJ, Moreaux G, Rupec RA, Gerhard M, Schmid R, Barker N, Clevers H, Lang R, Neumann J, Kirchner T, Taketo MM, van den Brink GR, Sansom OJ, Arkan MC, Greten FR. Schwitalla S, et al. Cell. 2013 Jan 17;152(1-2):25-38. doi: 10.1016/j.cell.2012.12.012. Epub 2012 Dec 27. Cell. 2013. PMID: 23273993 Free article.
Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors.
Schwitalla S, Ziegler PK, Horst D, Becker V, Kerle I, Begus-Nahrmann Y, Lechel A, Rudolph KL, Langer R, Slotta-Huspenina J, Bader FG, Prazeres da Costa O, Neurath MF, Meining A, Kirchner T, Greten FR. Schwitalla S, et al. Cancer Cell. 2013 Jan 14;23(1):93-106. doi: 10.1016/j.ccr.2012.11.014. Epub 2012 Dec 27. Cancer Cell. 2013. PMID: 23273920 Free article.
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