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2019 3
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Page 1
Mutation informatics: SARS-CoV-2 receptor-binding domain of the spike protein.
Verma S, Patil VM, Gupta MK. Verma S, et al. Drug Discov Today. 2022 Oct;27(10):103312. doi: 10.1016/j.drudis.2022.06.012. Epub 2022 Jul 3. Drug Discov Today. 2022. PMID: 35787481 Free PMC article. Review.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) undergoes mutations at a high rate and with frequent genetic reassortment (antigenic drift/shift), leading to variability in targets. The receptor-binding domain (RBD) of the spike (S) …
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) undergoes mutations at a high rate and with …
D614G mutation and SARS-CoV-2: impact on S-protein structure, function, infectivity, and immunity.
Bhattacharya M, Chatterjee S, Sharma AR, Agoramoorthy G, Chakraborty C. Bhattacharya M, et al. Appl Microbiol Biotechnol. 2021 Dec;105(24):9035-9045. doi: 10.1007/s00253-021-11676-2. Epub 2021 Nov 10. Appl Microbiol Biotechnol. 2021. PMID: 34755213 Free PMC article. Review.
The progression of the COVID-19 pandemic has generated numerous emerging variants of SARS-CoV-2 on a global scale. These variants have gained evolutionary advantages, comprising high virulence and serious infectivity due to multiple spike glycoprotein muta …
The progression of the COVID-19 pandemic has generated numerous emerging variants of SARS-CoV-2 on a global scale. Thes …
A pseudovirus system enables deep mutational scanning of the full SARS-CoV-2 spike.
Dadonaite B, Crawford KHD, Radford CE, Farrell AG, Yu TC, Hannon WW, Zhou P, Andrabi R, Burton DR, Liu L, Ho DD, Chu HY, Neher RA, Bloom JD. Dadonaite B, et al. Cell. 2023 Mar 16;186(6):1263-1278.e20. doi: 10.1016/j.cell.2023.02.001. Epub 2023 Feb 13. Cell. 2023. PMID: 36868218 Free PMC article.
A major challenge in understanding SARS-CoV-2 evolution is interpreting the antigenic and functional effects of emerging mutations in the viral spike protein. ...These libraries each contain 7,000 distinct amino acid mutations in the context of …
A major challenge in understanding SARS-CoV-2 evolution is interpreting the antigenic and functional effects of emergin …
The Mutational Landscape of SARS-CoV-2.
Saldivar-Espinoza B, Garcia-Segura P, Novau-Ferré N, Macip G, Martínez R, Puigbò P, Cereto-Massagué A, Pujadas G, Garcia-Vallve S. Saldivar-Espinoza B, et al. Int J Mol Sci. 2023 May 22;24(10):9072. doi: 10.3390/ijms24109072. Int J Mol Sci. 2023. PMID: 37240420 Free PMC article.
Using over 5,300,000 sequences from SARS-CoV-2 genomes and custom Python programs, we analyzed the mutational landscape of SARS-CoV-2. ...Therefore, ongoing monitoring of SARS-CoV-2 mutations is crucial. …
Using over 5,300,000 sequences from SARS-CoV-2 genomes and custom Python programs, we analyzed the mutational la …
Mutations Strengthened SARS-CoV-2 Infectivity.
Chen J, Wang R, Wang M, Wei GW. Chen J, et al. J Mol Biol. 2020 Sep 4;432(19):5212-5226. doi: 10.1016/j.jmb.2020.07.009. Epub 2020 Jul 23. J Mol Biol. 2020. PMID: 32710986 Free PMC article.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectivity is a major concern in coronavirus disease 2019 (COVID-19) prevention and economic reopening. ...Based on a systematic evaluation of all possible 3686 future mutations on th …
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectivity is a major concern in coronavirus disea …
Emerging mutation in SARS-CoV-2 facilitates escape from NK cell recognition and associates with enhanced viral fitness.
Bilev E, Wild N, Momayyezi P, Sala BM, Sun R, Sandalova T, Marquardt N, Ljunggren HG, Achour A, Hammer Q. Bilev E, et al. PLoS Pathog. 2024 Dec 9;20(12):e1012755. doi: 10.1371/journal.ppat.1012755. eCollection 2024 Dec. PLoS Pathog. 2024. PMID: 39652590 Free PMC article.
In addition to adaptive immunity, natural killer (NK) cells of the innate immune system contribute to the control of viral infections. The HLA-E-restricted SARS-CoV-2 Nsp13232-240 epitope VMPLSAPTL renders infected cells susceptible to NK cells by preventing …
In addition to adaptive immunity, natural killer (NK) cells of the innate immune system contribute to the control of viral infections. The H …
Research progress of spike protein mutation of SARS-CoV-2 mutant strain and antibody development.
Huan X, Zhan J, Gao H. Huan X, et al. Front Immunol. 2024 Nov 18;15:1407149. doi: 10.3389/fimmu.2024.1407149. eCollection 2024. Front Immunol. 2024. PMID: 39624100 Free PMC article. Review.
The coronavirus disease 2019 (COVID-19) is a respiratory disease with a very high infectious rate caused by the Severe Acute Respiratory Syndrome Coronavirus-2(SARS-CoV-2). Because SARS-CoV-2 is easy to mutate, the continuou …
The coronavirus disease 2019 (COVID-19) is a respiratory disease with a very high infectious rate caused by the Severe Acute Respiratory Syn …
Modelling SARS-CoV-2 spike-protein mutation effects on ACE2 binding.
Thakur S, Verma RK, Kepp KP, Mehra R. Thakur S, et al. J Mol Graph Model. 2023 Mar;119:108379. doi: 10.1016/j.jmgm.2022.108379. Epub 2022 Nov 24. J Mol Graph Model. 2023. PMID: 36481587 Free PMC article.
The binding affinity of the SARS-CoV-2 spike (S)-protein to the human membrane protein ACE2 is critical for virus function. ...Our results demonstrate substantial challenges but indicate ways forward to improve the quality of computer models for assessing …
The binding affinity of the SARS-CoV-2 spike (S)-protein to the human membrane protein ACE2 is critical for virus funct …
Molecular biology of SARS-CoV-2 and techniques of diagnosis and surveillance.
Ishige T. Ishige T. Adv Clin Chem. 2024;118:35-85. doi: 10.1016/bs.acc.2023.11.003. Epub 2023 Dec 14. Adv Clin Chem. 2024. PMID: 38280807 Review.
The World Health Organization (WHO) declared coronavirus disease 2019 (COVID-19), a disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a global pandemic in March 2020. Reverse transcription-polymerase chain reaction (RT …
The World Health Organization (WHO) declared coronavirus disease 2019 (COVID-19), a disease caused by the severe acute respiratory syndrome …
Evolution of the SARS-CoV-2 Mutational Spectrum.
Bloom JD, Beichman AC, Neher RA, Harris K. Bloom JD, et al. Mol Biol Evol. 2023 Apr 4;40(4):msad085. doi: 10.1093/molbev/msad085. Mol Biol Evol. 2023. PMID: 37039557 Free PMC article.
SARS-CoV-2 evolves rapidly in part because of its high mutation rate. Here, we examine whether this mutational process itself has changed during viral evolution. ...Mutational spectra distinguish SARS-CoV-2 replicatio …
SARS-CoV-2 evolves rapidly in part because of its high mutation rate. Here, we examine whether this mutationa …
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