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F901318 represents a novel class of antifungal drug that inhibits dihydroorotate dehydrogenase.
Oliver JD, Sibley GEM, Beckmann N, Dobb KS, Slater MJ, McEntee L, du Pré S, Livermore J, Bromley MJ, Wiederhold NP, Hope WW, Kennedy AJ, Law D, Birch M. Oliver JD, et al. Among authors: du pre s. Proc Natl Acad Sci U S A. 2016 Nov 8;113(45):12809-12814. doi: 10.1073/pnas.1608304113. Epub 2016 Oct 25. Proc Natl Acad Sci U S A. 2016. PMID: 27791100 Free PMC article.
Kinome analysis of Madurella mycetomatis identified kinases in the cell wall integrity pathway as novel potential therapeutic drug targets in eumycetoma caused by Madurella mycetomatis.
Konings M, Strepis N, Manabe RI, Hasegawa A, Chaudhari S, du Pré S, Schippers M, Tagami M, Ma J, Okazaki Y, Todd M, Biersack B, Masand V, Verbon A, Kasukawa T, Abugessaisa I, van de Sande WWJ. Konings M, et al. Among authors: du pre s. PLoS Negl Trop Dis. 2025 Sep 4;19(9):e0013482. doi: 10.1371/journal.pntd.0013482. eCollection 2025 Sep. PLoS Negl Trop Dis. 2025. PMID: 40906790 Free PMC article.
The pathway intermediate 2-keto-3-deoxy-L-galactonate mediates the induction of genes involved in D-galacturonic acid utilization in Aspergillus niger.
Alazi E, Khosravi C, Homan TG, du Pré S, Arentshorst M, Di Falco M, Pham TTM, Peng M, Aguilar-Pontes MV, Visser J, Tsang A, de Vries RP, Ram AFJ. Alazi E, et al. Among authors: du pre s. FEBS Lett. 2017 May;591(10):1408-1418. doi: 10.1002/1873-3468.12654. Epub 2017 May 6. FEBS Lett. 2017. PMID: 28417461 Free PMC article.