Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2010 1
2011 1
2013 2
2014 1
2015 2
2016 4
2017 1
2018 3
2020 2
2021 3
2022 2
2023 0

Text availability

Article attribute

Article type

Publication date

Search Results

17 results

Results by year

Filters applied: . Clear all
Page 1
Sceletium tortuosum: A review on its phytochemistry, pharmacokinetics, biological and clinical activities.
Olatunji TL, Siebert F, Adetunji AE, Harvey BH, Gericke J, Hamman JH, Van der Kooy F. Olatunji TL, et al. J Ethnopharmacol. 2021 Nov 15;280:114476. doi: 10.1016/j.jep.2021.114476. Epub 2021 Jul 30. J Ethnopharmacol. 2021. PMID: 34333104 Review.
ETHNOPHARMACOLOGICAL RELEVANCE: Sceletium tortuosum (L.) N.E.Br, the most sought after and widely researched species in the genus Sceletium is a succulent forb endemic to South Africa. ...RESULTS: Twenty-five alkaloids belonging to four structural classes viz …
ETHNOPHARMACOLOGICAL RELEVANCE: Sceletium tortuosum (L.) N.E.Br, the most sought after and widely researched species in the ge …
Sceletium tortuosum (Zembrin® ) ameliorates experimentally induced anxiety in healthy volunteers.
Reay J, Wetherell MA, Morton E, Lillis J, Badmaev V. Reay J, et al. Hum Psychopharmacol. 2020 Nov;35(6):1-7. doi: 10.1002/hup.2753. Epub 2020 Aug 6. Hum Psychopharmacol. 2020. PMID: 32761980 Clinical Trial.
OBJECTIVE: To investigate the anxiolytic properties of a standardized extract of Sceletium tortuosum (trademarked-Zembrin() ). METHODS: Two studies utilized a placebo-controlled, double-blind, between-subject experimental design to investigate the effects of a singl …
OBJECTIVE: To investigate the anxiolytic properties of a standardized extract of Sceletium tortuosum (trademarked-Zembrin() ). …
The effects of Sceletium tortuosum in an in vivo model of psychological stress.
Smith C. Smith C. J Ethnopharmacol. 2011 Jan 7;133(1):31-6. doi: 10.1016/j.jep.2010.08.058. Epub 2010 Sep 17. J Ethnopharmacol. 2011. PMID: 20816940
AIM OF THE STUDY: Sceletium, and especially Sceletium tortuosum, is traditionally used as masticator and thought to have a sedative effect which may be beneficial to reduce symptoms of anxiety and/or depression. ...RESULTS: Behavior indicated a limited effect …
AIM OF THE STUDY: Sceletium, and especially Sceletium tortuosum, is traditionally used as masticator and thought to hav …
Sceletium tortuosum: A review on its phytochemistry, pharmacokinetics, biological, pre-clinical and clinical activities.
Olatunji TL, Siebert F, Adetunji AE, Harvey BH, Gericke J, Hamman JH, Van der Kooy F. Olatunji TL, et al. J Ethnopharmacol. 2022 Apr 6;287:114711. doi: 10.1016/j.jep.2021.114711. Epub 2021 Nov 8. J Ethnopharmacol. 2022. PMID: 34758918
ETHNOPHARMACOLOGICAL RELEVANCE: Sceletium tortuosum (L.) N.E.Br., the most sought after and widely researched species in the genus Sceletium is a succulent forb endemic to South Africa. ...RESULTS: Twenty-five alkaloids belonging to four structural classes vi …
ETHNOPHARMACOLOGICAL RELEVANCE: Sceletium tortuosum (L.) N.E.Br., the most sought after and widely researched species in the g …
A Chewable Cure "Kanna": Biological and Pharmaceutical Properties of Sceletium tortuosum.
Manganyi MC, Bezuidenhout CC, Regnier T, Ateba CN. Manganyi MC, et al. Molecules. 2021 Apr 28;26(9):2557. doi: 10.3390/molecules26092557. Molecules. 2021. PMID: 33924742 Free PMC article. Review.
Sceletium tortuosum (L.) N.E.Br. (Mesembryanthemaceae), commonly known as kanna or kougoed, is an effective indigenous medicinal plant in South Africa, specifically to the native San and Khoikhoi tribes. ...Various studies have revealed that extracts of the plant ha …
Sceletium tortuosum (L.) N.E.Br. (Mesembryanthemaceae), commonly known as kanna or kougoed, is an effective indigenous medicin …
The effects of Sceletium tortuosum (L.) N.E. Br. extract fraction in the chick anxiety-depression model.
Carpenter JM, Jourdan MK, Fountain EM, Ali Z, Abe N, Khan IA, Sufka KJ. Carpenter JM, et al. J Ethnopharmacol. 2016 Dec 4;193:329-332. doi: 10.1016/j.jep.2016.08.019. Epub 2016 Aug 20. J Ethnopharmacol. 2016. PMID: 27553978
ETHNOPHARMACOLOGICAL RELEVANCE: Sceletium tortuosum (L.) N.E. Br. has been reported to elevate mood, reduce anxiety and stress and alleviate pain. ...CONCLUSIONS: The findings suggest that an alkaloid enriched S. tortuosum fraction may benefit some for …
ETHNOPHARMACOLOGICAL RELEVANCE: Sceletium tortuosum (L.) N.E. Br. has been reported to elevate mood, reduce anxiety and str …
Sceletium tortuosum may delay chronic disease progression via alkaloid-dependent antioxidant or anti-inflammatory action.
Bennett AC, Van Camp A, López V, Smith C. Bennett AC, et al. J Physiol Biochem. 2018 Nov;74(4):539-547. doi: 10.1007/s13105-018-0620-6. Epub 2018 Mar 9. J Physiol Biochem. 2018. PMID: 29520661
It is also known that peripherally produced inflammatory cytokines can cross the blood-brain barrier, resulting in the release of neurotoxins that can ultimately lead to the demise of central nervous system integrity. A high-mesembrine Sceletium tortuosum extract wa …
It is also known that peripherally produced inflammatory cytokines can cross the blood-brain barrier, resulting in the release of neurotoxin …
A randomized, double-blind, parallel-group, placebo-controlled trial of Extract Sceletium tortuosum (Zembrin) in healthy adults.
Nell H, Siebert M, Chellan P, Gericke N. Nell H, et al. J Altern Complement Med. 2013 Nov;19(11):898-904. doi: 10.1089/acm.2012.0185. Epub 2013 Feb 26. J Altern Complement Med. 2013. PMID: 23441963 Clinical Trial.
Of the 37 subjects, 12, 12, and 13 subjects received 8 mg extract Sceletium tortuosum (Zembrin), 25 mg extract Sceletium tortuosum (Zembrin), and placebo treatment, respectively. ...Unsolicited positive effects on well-being were noted in patient diari …
Of the 37 subjects, 12, 12, and 13 subjects received 8 mg extract Sceletium tortuosum (Zembrin), 25 mg extract Sceletium …
1H-NMR and UPLC-MS metabolomics: Functional tools for exploring chemotypic variation in Sceletium tortuosum from two provinces in South Africa.
Zhao J, Khan IA, Combrinck S, Sandasi M, Chen W, Viljoen AM. Zhao J, et al. Phytochemistry. 2018 Aug;152:191-203. doi: 10.1016/j.phytochem.2018.03.013. Epub 2018 May 21. Phytochemistry. 2018. PMID: 29783186
Sceletium tortuosum (Aizoaceae) is widely recognised for the treatment of stress, anxiety and depression, as well as for obsessive compulsive disorders. ...Two dimensional (2D) NMR was used to identify analytes that contributed to the clustering as revealed b …
Sceletium tortuosum (Aizoaceae) is widely recognised for the treatment of stress, anxiety and depression, as well as fo …
Mesembryanthemum tortuosum L. alkaloids modify anxiety-like behaviour in a zebrafish model.
Maphanga VB, Skalicka-Wozniak K, Budzynska B, Skiba A, Chen W, Agoni C, Enslin GM, Viljoen AM. Maphanga VB, et al. J Ethnopharmacol. 2022 May 23;290:115068. doi: 10.1016/j.jep.2022.115068. Epub 2022 Feb 5. J Ethnopharmacol. 2022. PMID: 35134486
ETHNOPHARMACOLOGICAL RELEVANCE: Mesembryanthemum tortuosum L. (previously known as Sceletium tortuosum (L.) N.E. Br.) is indigenous to South Africa and traditionally used to alleviate anxiety, stress and depression. Mesembrine and its alkaloid analogue …
ETHNOPHARMACOLOGICAL RELEVANCE: Mesembryanthemum tortuosum L. (previously known as Sceletium tortuosum (L.) N.E. Br.) i …
17 results