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Sceletium tortuosum: A review on its phytochemistry, pharmacokinetics, biological and clinical activities.
Olatunji TL, Siebert F, Adetunji AE, Harvey BH, Gericke J, Hamman JH, Van der Kooy F. Olatunji TL, et al. J Ethnopharmacol. 2021 Nov 15;280:114476. doi: 10.1016/j.jep.2021.114476. Epub 2021 Jul 30. J Ethnopharmacol. 2021. PMID: 34333104 Review.
ETHNOPHARMACOLOGICAL RELEVANCE: Sceletium tortuosum (L.) N.E.Br, the most sought after and widely researched species in the genus Sceletium is a succulent forb endemic to South Africa. ...For pharmacokinetics and pharmacological effects of S. tortuosum …
ETHNOPHARMACOLOGICAL RELEVANCE: Sceletium tortuosum (L.) N.E.Br, the most sought after and widely researched species in the ge …
The effects of Sceletium tortuosum in an in vivo model of psychological stress.
Smith C. Smith C. J Ethnopharmacol. 2011 Jan 7;133(1):31-6. doi: 10.1016/j.jep.2010.08.058. Epub 2010 Sep 17. J Ethnopharmacol. 2011. PMID: 20816940
AIM OF THE STUDY: Sceletium, and especially Sceletium tortuosum, is traditionally used as masticator and thought to have a sedative effect which may be beneficial to reduce symptoms of anxiety and/or depression. ...RESULTS: Behavior indicated a limited effect …
AIM OF THE STUDY: Sceletium, and especially Sceletium tortuosum, is traditionally used as masticator and thought to hav …
Sceletium tortuosum: A review on its phytochemistry, pharmacokinetics, biological, pre-clinical and clinical activities.
Olatunji TL, Siebert F, Adetunji AE, Harvey BH, Gericke J, Hamman JH, Van der Kooy F. Olatunji TL, et al. J Ethnopharmacol. 2022 Apr 6;287:114711. doi: 10.1016/j.jep.2021.114711. Epub 2021 Nov 8. J Ethnopharmacol. 2022. PMID: 34758918
ETHNOPHARMACOLOGICAL RELEVANCE: Sceletium tortuosum (L.) N.E.Br., the most sought after and widely researched species in the genus Sceletium is a succulent forb endemic to South Africa. ...For pharmacokinetics and pharmacological effects of S. tortuosum …
ETHNOPHARMACOLOGICAL RELEVANCE: Sceletium tortuosum (L.) N.E.Br., the most sought after and widely researched species in the g …
A Chewable Cure "Kanna": Biological and Pharmaceutical Properties of Sceletium tortuosum.
Manganyi MC, Bezuidenhout CC, Regnier T, Ateba CN. Manganyi MC, et al. Molecules. 2021 Apr 28;26(9):2557. doi: 10.3390/molecules26092557. Molecules. 2021. PMID: 33924742 Free PMC article. Review.
Sceletium tortuosum (L.) N.E.Br. (Mesembryanthemaceae), commonly known as kanna or kougoed, is an effective indigenous medicinal plant in South Africa, specifically to the native San and Khoikhoi tribes. ...Various studies have revealed that extracts of the plant ha …
Sceletium tortuosum (L.) N.E.Br. (Mesembryanthemaceae), commonly known as kanna or kougoed, is an effective indigenous medicin …
Sceletium tortuosum (Zembrin() ) ameliorates experimentally induced anxiety in healthy volunteers.
Reay J, Wetherell MA, Morton E, Lillis J, Badmaev V. Reay J, et al. Hum Psychopharmacol. 2020 Nov;35(6):1-7. doi: 10.1002/hup.2753. Epub 2020 Aug 6. Hum Psychopharmacol. 2020. PMID: 32761980 Clinical Trial.
OBJECTIVE: To investigate the anxiolytic properties of a standardized extract of Sceletium tortuosum (trademarked-Zembrin() ). METHODS: Two studies utilized a placebo-controlled, double-blind, between-subject experimental design to investigate the effects of a singl …
OBJECTIVE: To investigate the anxiolytic properties of a standardized extract of Sceletium tortuosum (trademarked-Zembrin() ). …
The effects of Sceletium tortuosum (L.) N.E. Br. extract fraction in the chick anxiety-depression model.
Carpenter JM, Jourdan MK, Fountain EM, Ali Z, Abe N, Khan IA, Sufka KJ. Carpenter JM, et al. J Ethnopharmacol. 2016 Dec 4;193:329-332. doi: 10.1016/j.jep.2016.08.019. Epub 2016 Aug 20. J Ethnopharmacol. 2016. PMID: 27553978
ETHNOPHARMACOLOGICAL RELEVANCE: Sceletium tortuosum (L.) N.E. Br. has been reported to elevate mood, reduce anxiety and stress and alleviate pain. ...CONCLUSIONS: The findings suggest that an alkaloid enriched S. tortuosum fraction may benefit some for …
ETHNOPHARMACOLOGICAL RELEVANCE: Sceletium tortuosum (L.) N.E. Br. has been reported to elevate mood, reduce anxiety and str …
Sceletium tortuosum may delay chronic disease progression via alkaloid-dependent antioxidant or anti-inflammatory action.
Bennett AC, Van Camp A, López V, Smith C. Bennett AC, et al. J Physiol Biochem. 2018 Nov;74(4):539-547. doi: 10.1007/s13105-018-0620-6. Epub 2018 Mar 9. J Physiol Biochem. 2018. PMID: 29520661
Given the interlinked nature of glucocorticoid action and inflammation, central immunomodulatory effects of two Sceletium tortuosum extracts prepared by different extraction methods were investigated. ...We conclude that both Sceletium tortuosum extrac …
Given the interlinked nature of glucocorticoid action and inflammation, central immunomodulatory effects of two Sceletium tortuosu …
A toxicological safety assessment of a standardized extract of Sceletium tortuosum (Zembrin) in rats.
Murbach TS, Hirka G, Szakonyiné IP, Gericke N, Endres JR. Murbach TS, et al. Food Chem Toxicol. 2014 Dec;74:190-9. doi: 10.1016/j.fct.2014.09.017. Epub 2014 Oct 6. Food Chem Toxicol. 2014. PMID: 25301237 Free article.
A well-characterized standardized hydroethanolic extract of a traditionally recognized mak (mild) variety of Sceletium tortuosum, a South African plant with a long history of traditional ingestion, is marketed under the trade name Zembrin() as an ingredient for use …
A well-characterized standardized hydroethanolic extract of a traditionally recognized mak (mild) variety of Sceletium tortuosum …
Mesembryanthemum tortuosum L. alkaloids modify anxiety-like behaviour in a zebrafish model.
Maphanga VB, Skalicka-Wozniak K, Budzynska B, Skiba A, Chen W, Agoni C, Enslin GM, Viljoen AM. Maphanga VB, et al. J Ethnopharmacol. 2022 May 23;290:115068. doi: 10.1016/j.jep.2022.115068. Epub 2022 Feb 5. J Ethnopharmacol. 2022. PMID: 35134486
ETHNOPHARMACOLOGICAL RELEVANCE: Mesembryanthemum tortuosum L. (previously known as Sceletium tortuosum (L.) N.E. Br.) is indigenous to South Africa and traditionally used to alleviate anxiety, stress and depression. Mesembrine and its alkaloid analogue …
ETHNOPHARMACOLOGICAL RELEVANCE: Mesembryanthemum tortuosum L. (previously known as Sceletium tortuosum (L.) N.E. Br.) i …
A randomized, double-blind, parallel-group, placebo-controlled trial of Extract Sceletium tortuosum (Zembrin) in healthy adults.
Nell H, Siebert M, Chellan P, Gericke N. Nell H, et al. J Altern Complement Med. 2013 Nov;19(11):898-904. doi: 10.1089/acm.2012.0185. Epub 2013 Feb 26. J Altern Complement Med. 2013. PMID: 23441963 Clinical Trial.
Of the 37 subjects, 12, 12, and 13 subjects received 8 mg extract Sceletium tortuosum (Zembrin), 25 mg extract Sceletium tortuosum (Zembrin), and placebo treatment, respectively. ...Unsolicited positive effects on well-being were noted in patient diari …
Of the 37 subjects, 12, 12, and 13 subjects received 8 mg extract Sceletium tortuosum (Zembrin), 25 mg extract Sceletium …
17 results