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The effects of Sceletium tortuosum in an in vivo model of psychological stress.
Smith C. Smith C. J Ethnopharmacol. 2011 Jan 7;133(1):31-6. doi: 10.1016/j.jep.2010.08.058. Epub 2010 Sep 17. J Ethnopharmacol. 2011. PMID: 20816940
AIM OF THE STUDY: Sceletium, and especially Sceletium tortuosum, is traditionally used as masticator and thought to have a sedative effect which may be beneficial to reduce symptoms of anxiety and/or depression. ...RESULTS: Behavior indicated a limited effect …
AIM OF THE STUDY: Sceletium, and especially Sceletium tortuosum, is traditionally used as masticator and thought to hav …
Sceletium tortuosum (Zembrin() ) ameliorates experimentally induced anxiety in healthy volunteers.
Reay J, Wetherell MA, Morton E, Lillis J, Badmaev V. Reay J, et al. Hum Psychopharmacol. 2020 Nov;35(6):1-7. doi: 10.1002/hup.2753. Epub 2020 Aug 6. Hum Psychopharmacol. 2020. PMID: 32761980 Clinical Trial.
OBJECTIVE: To investigate the anxiolytic properties of a standardized extract of Sceletium tortuosum (trademarked-Zembrin() ). METHODS: Two studies utilized a placebo-controlled, double-blind, between-subject experimental design to investigate the effects of a singl …
OBJECTIVE: To investigate the anxiolytic properties of a standardized extract of Sceletium tortuosum (trademarked-Zembrin() ). …
The effects of Sceletium tortuosum (L.) N.E. Br. extract fraction in the chick anxiety-depression model.
Carpenter JM, Jourdan MK, Fountain EM, Ali Z, Abe N, Khan IA, Sufka KJ. Carpenter JM, et al. J Ethnopharmacol. 2016 Dec 4;193:329-332. doi: 10.1016/j.jep.2016.08.019. Epub 2016 Aug 20. J Ethnopharmacol. 2016. PMID: 27553978
ETHNOPHARMACOLOGICAL RELEVANCE: Sceletium tortuosum (L.) N.E. Br. has been reported to elevate mood, reduce anxiety and stress and alleviate pain. ...CONCLUSIONS: The findings suggest that an alkaloid enriched S. tortuosum fraction may benefit some for …
ETHNOPHARMACOLOGICAL RELEVANCE: Sceletium tortuosum (L.) N.E. Br. has been reported to elevate mood, reduce anxiety and str
Sceletium tortuosum may delay chronic disease progression via alkaloid-dependent antioxidant or anti-inflammatory action.
Bennett AC, Van Camp A, López V, Smith C. Bennett AC, et al. J Physiol Biochem. 2018 Nov;74(4):539-547. doi: 10.1007/s13105-018-0620-6. Epub 2018 Mar 9. J Physiol Biochem. 2018. PMID: 29520661
It is also known that peripherally produced inflammatory cytokines can cross the blood-brain barrier, resulting in the release of neurotoxins that can ultimately lead to the demise of central nervous system integrity. A high-mesembrine Sceletium tortuosum extract wa …
It is also known that peripherally produced inflammatory cytokines can cross the blood-brain barrier, resulting in the release of neurotoxin …
Ergogenic Effects of 8 Days of Sceletium Tortuosum Supplementation on Mood, Visual Tracking, and Reaction in Recreationally Trained Men and Women.
Hoffman JR, Markus I, Dubnov-Raz G, Gepner Y. Hoffman JR, et al. J Strength Cond Res. 2020 Sep;34(9):2476-2481. doi: 10.1519/JSC.0000000000003693. J Strength Cond Res. 2020. PMID: 32740286 Clinical Trial.
Hoffman, JR, Marcus, I, Dubnov-Raz, G, and Gepner, Y. Ergogenic effects of 8 days of Sceletium tortuosum supplementation on mood, visual tracking, and reaction in recreationally trained men and women. J Strength Cond Res 34(9): 2476-2481, 2020-Sceletium to
Hoffman, JR, Marcus, I, Dubnov-Raz, G, and Gepner, Y. Ergogenic effects of 8 days of Sceletium tortuosum supplementation on mo …
A randomized, double-blind, parallel-group, placebo-controlled trial of Extract Sceletium tortuosum (Zembrin) in healthy adults.
Nell H, Siebert M, Chellan P, Gericke N. Nell H, et al. J Altern Complement Med. 2013 Nov;19(11):898-904. doi: 10.1089/acm.2012.0185. Epub 2013 Feb 26. J Altern Complement Med. 2013. PMID: 23441963 Clinical Trial.
Of the 37 subjects, 12, 12, and 13 subjects received 8 mg extract Sceletium tortuosum (Zembrin), 25 mg extract Sceletium tortuosum (Zembrin), and placebo treatment, respectively. ...Unsolicited positive effects on well-being were noted in patient diari …
Of the 37 subjects, 12, 12, and 13 subjects received 8 mg extract Sceletium tortuosum (Zembrin), 25 mg extract Sceletium
Sceletium tortuosum: A review on its phytochemistry, pharmacokinetics, biological and clinical activities.
Olatunji TL, Siebert F, Adetunji AE, Harvey BH, Gericke J, Hamman JH, Van der Kooy F. Olatunji TL, et al. J Ethnopharmacol. 2021 Nov 15;280:114476. doi: 10.1016/j.jep.2021.114476. Epub 2021 Jul 30. J Ethnopharmacol. 2021. PMID: 34333104 Review.
ETHNOPHARMACOLOGICAL RELEVANCE: Sceletium tortuosum (L.) N.E.Br, the most sought after and widely researched species in the genus Sceletium is a succulent forb endemic to South Africa. ...RESULTS: Twenty-five alkaloids belonging to four structural classes viz …
ETHNOPHARMACOLOGICAL RELEVANCE: Sceletium tortuosum (L.) N.E.Br, the most sought after and widely researched species in the ge …
(1)H-NMR and UPLC-MS metabolomics: Functional tools for exploring chemotypic variation in Sceletium tortuosum from two provinces in South Africa.
Zhao J, Khan IA, Combrinck S, Sandasi M, Chen W, Viljoen AM. Zhao J, et al. Phytochemistry. 2018 Aug;152:191-203. doi: 10.1016/j.phytochem.2018.03.013. Epub 2018 May 21. Phytochemistry. 2018. PMID: 29783186
Sceletium tortuosum (Aizoaceae) is widely recognised for the treatment of stress, anxiety and depression, as well as for obsessive compulsive disorders. ...Two dimensional (2D) NMR was used to identify analytes that contributed to the clustering as revealed b
Sceletium tortuosum (Aizoaceae) is widely recognised for the treatment of stress, anxiety and depression, as well as fo
A toxicological safety assessment of a standardized extract of Sceletium tortuosum (Zembrin) in rats.
Murbach TS, Hirka G, Szakonyiné IP, Gericke N, Endres JR. Murbach TS, et al. Food Chem Toxicol. 2014 Dec;74:190-9. doi: 10.1016/j.fct.2014.09.017. Epub 2014 Oct 6. Food Chem Toxicol. 2014. PMID: 25301237 Free article.
A well-characterized standardized hydroethanolic extract of a traditionally recognized mak (mild) variety of Sceletium tortuosum, a South African plant with a long history of traditional ingestion, is marketed under the trade name Zembrin() as an ingredient for use …
A well-characterized standardized hydroethanolic extract of a traditionally recognized mak (mild) variety of Sceletium tortuosum
Acute effects of Sceletium tortuosum (Zembrin), a dual 5-HT reuptake and PDE4 inhibitor, in the human amygdala and its connection to the hypothalamus.
Terburg D, Syal S, Rosenberger LA, Heany S, Phillips N, Gericke N, Stein DJ, van Honk J. Terburg D, et al. Neuropsychopharmacology. 2013 Dec;38(13):2708-16. doi: 10.1038/npp.2013.183. Epub 2013 Aug 1. Neuropsychopharmacology. 2013. PMID: 23903032 Free PMC article. Clinical Trial.
The South African endemic plant Sceletium tortuosum has a long history of traditional use as a masticatory and medicine by San and Khoikhoi people and subsequently by European colonial farmers as a psychotropic in tincture form. Over the past decade, the plant has a …
The South African endemic plant Sceletium tortuosum has a long history of traditional use as a masticatory and medicine by San …
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