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Absent in melanoma 2 (AIM2) in rheumatoid arthritis: novel molecular insights and implications.
Zhao J, Guo S, Schrodi SJ, He D. Zhao J, et al. Among authors: schrodi sj. Cell Mol Biol Lett. 2022 Dec 7;27(1):108. doi: 10.1186/s11658-022-00402-z. Cell Mol Biol Lett. 2022. PMID: 36476420 Free PMC article. Review.
Rheumatoid arthritis (RA) is an autoimmune disease that poses a severe threat to physical and mental health, and is caused by several genetic and metabolic factors. Multiple immune cells interact to form a complex inflammatory network that mediates inflammatory responses a …
Rheumatoid arthritis (RA) is an autoimmune disease that poses a severe threat to physical and mental health, and is caused by several gen
Trends in the Contribution of Genetic Susceptibility Loci to Hyperuricemia and Gout and Associated Novel Mechanisms.
Zhao J, Guo S, Schrodi SJ, He D. Zhao J, et al. Among authors: schrodi sj. Front Cell Dev Biol. 2022 Jun 23;10:937855. doi: 10.3389/fcell.2022.937855. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 35813212 Free PMC article. Review.
Genetic factors play an essential role in the development of hyperuricemia and gout. Currently, the search on disease-associated genetic variants through large-scale genome-wide scans has primarily improved our understanding of this disease. ...
Genetic factors play an essential role in the development of hyperuricemia and gout. Currently, the search on disease-associated g
Molecular and Cellular Heterogeneity in Rheumatoid Arthritis: Mechanisms and Clinical Implications.
Zhao J, Guo S, Schrodi SJ, He D. Zhao J, et al. Among authors: schrodi sj. Front Immunol. 2021 Nov 25;12:790122. doi: 10.3389/fimmu.2021.790122. eCollection 2021. Front Immunol. 2021. PMID: 34899757 Free PMC article. Review.
In this review, we discuss the source of pathophysiological heterogeneity derived from genetic, molecular, and cellular heterogeneity and their possible impact on precision medicine and personalized treatment of rheumatoid arthritis. ...
In this review, we discuss the source of pathophysiological heterogeneity derived from genetic, molecular, and cellular heterogeneity …
Remediation of ABCG5-Linked Macrothrombocytopenia With Ezetimibe Therapy.
Deng L, Xu J, Chen W, Guo S, Steiner RD, Chen Q, Cheng Z, Xu Y, Yao B, Li X, Wang X, Deng K, Schrodi SJ, Zhang D, Xin H. Deng L, et al. Among authors: schrodi sj. Front Genet. 2021 Nov 22;12:769699. doi: 10.3389/fgene.2021.769699. eCollection 2021. Front Genet. 2021. PMID: 34880906 Free PMC article.
These findings suggest that ABCG5 heterozygosity may cause macrothrombocytopenia, that Ezetimibe treatment may resolve macrothrombocytopenia in such individuals, and that increased attention to platelet size on complete blood counts can aid in the identification of candidates for …
These findings suggest that ABCG5 heterozygosity may cause macrothrombocytopenia, that Ezetimibe treatment may resolve macrothrombocytopenia …
MicroRNA Variants and HLA-miRNA Interactions are Novel Rheumatoid Arthritis Susceptibility Factors.
Guo S, Jin Y, Zhou J, Zhu Q, Jiang T, Bian Y, Zhang R, Chang C, Xu L, Shen J, Zheng X, Shen Y, Qin Y, Chen J, Tang X, Cheng P, Ding Q, Zhang Y, Liu J, Cheng Q, Guo M, Liu Z, Qiu W, Qian Y, Sun Y, Shen Y, Nie H, Schrodi SJ, He D. Guo S, et al. Among authors: schrodi sj. Front Genet. 2021 Oct 29;12:747274. doi: 10.3389/fgene.2021.747274. eCollection 2021. Front Genet. 2021. PMID: 34777472 Free PMC article.
Genome-wide association studies have identified >100 genetic risk factors for rheumatoid arthritis. However, the reported genetic variants could only explain less than 40% heritability of rheumatoid arthritis. ...
Genome-wide association studies have identified >100 genetic risk factors for rheumatoid arthritis. However, the reported genet
Mechanisms of DNA Methylation in Virus-Host Interaction in Hepatitis B Infection: Pathogenesis and Oncogenetic Properties.
Zhang D, Guo S, Schrodi SJ. Zhang D, et al. Among authors: schrodi sj. Int J Mol Sci. 2021 Sep 12;22(18):9858. doi: 10.3390/ijms22189858. Int J Mol Sci. 2021. PMID: 34576022 Free PMC article. Review.
Hepatitis B virus (HBV), the well-studied oncovirus that contributes to the majority of hepatocellular carcinomas (HCC) worldwide, can cause a severe inflammatory microenvironment leading to genetic and epigenetic changes in hepatocyte clones. HBV replication contributes t …
Hepatitis B virus (HBV), the well-studied oncovirus that contributes to the majority of hepatocellular carcinomas (HCC) worldwide, can cause …
Outcome of breast cancer patients with low hormone receptor positivity: analysis of a 15-year population-based cohort.
Schrodi S, Braun M, Andrulat A, Harbeck N, Mahner S, Kiechle M, Klein E, Schnelzer A, Schindlbeck C, Bauerfeind I, Schubert-Fritschle G, Nekljudova V, Mayr D, Weichert W, Denkert C, Loibl S, Engel J. Schrodi S, et al. Ann Oncol. 2021 Nov;32(11):1410-1424. doi: 10.1016/j.annonc.2021.08.1988. Epub 2021 Aug 20. Ann Oncol. 2021. PMID: 34419555 Free article.
Therapy response and prognosis of patients with early breast cancer with low positivity for hormone receptors - An analysis of 2765 patients from neoadjuvant clinical trials.
Villegas SL, Nekljudova V, Pfarr N, Engel J, Untch M, Schrodi S, Holms F, Ulmer HU, Fasching PA, Weber KE, Albig C, Heinrichs C, Marmé F, Hartmann A, Hanusch C, Schmitt WD, Huober J, Lederer B, van Mackelenbergh M, Tesch H, Jackisch C, Rezai M, Sinn P, Sinn BV, Hackmann J, Kiechle M, Schneeweiss A, Weichert W, Denkert C, Loibl S. Villegas SL, et al. Among authors: schrodi s. Eur J Cancer. 2021 May;148:159-170. doi: 10.1016/j.ejca.2021.02.020. Epub 2021 Mar 18. Eur J Cancer. 2021. PMID: 33743484
A gene-based recessive diplotype exome scan discovers FGF6, a novel hepcidin-regulating iron-metabolism gene.
Guo S, Jiang S, Epperla N, Ma Y, Maadooliat M, Ye Z, Olson B, Wang M, Kitchner T, Joyce J, An P, Wang F, Strenn R, Mazza JJ, Meece JK, Wu W, Jin L, Smith JA, Wang J, Schrodi SJ. Guo S, et al. Among authors: schrodi sj. Blood. 2019 Apr 25;133(17):1888-1898. doi: 10.1182/blood-2018-10-879585. Epub 2019 Feb 27. Blood. 2019. PMID: 30814063 Free PMC article.
[Breast cancer in male].
Würstlein R, Hesse A, König A, Schulte-Vorwick F, Schrodi S, Ditsch N, Mahner S, Harbeck N. Würstlein R, et al. Among authors: schrodi s. MMW Fortschr Med. 2017 Dec;159(21-22):67-72. doi: 10.1007/s15006-017-0395-7. MMW Fortschr Med. 2017. PMID: 29230744 Review. German. No abstract available.
The Impact of Diagnostic Code Misclassification on Optimizing the Experimental Design of Genetic Association Studies.
Schrodi SJ. Schrodi SJ. J Healthc Eng. 2017;2017:7653071. doi: 10.1155/2017/7653071. Epub 2017 Oct 18. J Healthc Eng. 2017. PMID: 29181145 Free PMC article.
As a growing number of health system databases become linked with genomic data, it is critically important to understand the effect of this misclassification on the power of genetic association studies. Here, I investigate the impact of this diagnostic code misclassificati …
As a growing number of health system databases become linked with genomic data, it is critically important to understand the effect of this …
Genetic and Functional Associations with Decreased Anti-inflammatory Tumor Necrosis Factor Alpha Induced Protein 3 in Macrophages from Subjects with Axial Spondyloarthritis.
Liu Y, Ye Z, Li X, Anderson JL, Khan M, DaSilva D, Baron M, Wilson D, Bocoun V, Ivacic LC, Schrodi SJ, Smith JA. Liu Y, et al. Among authors: schrodi sj. Front Immunol. 2017 Jul 24;8:860. doi: 10.3389/fimmu.2017.00860. eCollection 2017. Front Immunol. 2017. PMID: 28791018 Free PMC article.
We hypothesized that lower levels of TNFAIP3 contributes to excessive cytokine production in response to inflammatory stimuli in axial spondyloarthritis (AxSpA). A further aim was to determine the immune signaling and genetic variation regulating TNFAIP3 expression in indi …
We hypothesized that lower levels of TNFAIP3 contributes to excessive cytokine production in response to inflammatory stimuli in axial spond …
The Decay of Disease Association with Declining Linkage Disequilibrium: A Fine Mapping Theorem.
Maadooliat M, Bansal NK, Upadhya J, Farazi MR, Li X, He MM, Hebbring SJ, Ye Z, Schrodi SJ. Maadooliat M, et al. Among authors: schrodi sj. Front Genet. 2016 Dec 12;7:217. doi: 10.3389/fgene.2016.00217. eCollection 2016. Front Genet. 2016. PMID: 28018425 Free PMC article.
Several important and fundamental aspects of disease genetics models have yet to be described. One such property is the relationship of disease association statistics at a marker site closely linked to a disease causing site. ...Quite interestingly, this relationship holds …
Several important and fundamental aspects of disease genetics models have yet to be described. One such property is the relationship …
Validation of a metabolite panel for early diagnosis of type 2 diabetes.
Carter TC, Rein D, Padberg I, Peter E, Rennefahrt U, David DE, McManus V, Stefanski E, Martin S, Schatz P, Schrodi SJ. Carter TC, et al. Among authors: schrodi sj. Metabolism. 2016 Sep;65(9):1399-408. doi: 10.1016/j.metabol.2016.06.007. Epub 2016 Jun 26. Metabolism. 2016. PMID: 27506746 Free PMC article.
Reflections on the Field of Human Genetics: A Call for Increased Disease Genetics Theory.
Schrodi SJ. Schrodi SJ. Front Genet. 2016 Jun 8;7:106. doi: 10.3389/fgene.2016.00106. eCollection 2016. Front Genet. 2016. PMID: 27375680 Free PMC article.
In particular, the development of new, realistic disease genetics models will help elucidate complex disease pathogenesis, and the predicted patterns in genetic data made by these models will enable the concurrent, more comprehensive statistical testing of multiple …
In particular, the development of new, realistic disease genetics models will help elucidate complex disease pathogenesis, and the pr …
Cell line donor genotype and its influence on experimental phenotype: Toll-like receptor SNPs and potential variability in innate immunity.
Tokarz SA, DeValk J, Luo W, Pattnaik BR, Schrodi SJ, Pillers DM. Tokarz SA, et al. Among authors: schrodi sj. Mol Genet Metab. 2016 Jul;118(3):147-152. doi: 10.1016/j.ymgme.2016.04.011. Epub 2016 Apr 22. Mol Genet Metab. 2016. PMID: 27324283
Cell lines are used to model a disease and provide valuable information regarding phenotype, mechanism, and response to novel therapies. Derived from individuals of diverse genetic backgrounds, the cell's genetic complement predicts the phenotype, and although some …
Cell lines are used to model a disease and provide valuable information regarding phenotype, mechanism, and response to novel therapies. Der …
The Use of Multiplicity Corrections, Order Statistics and Generalized Family-Wise Statistics with Application to Genome-Wide Studies.
Schrodi SJ. Schrodi SJ. PLoS One. 2016 Apr 29;11(4):e0154472. doi: 10.1371/journal.pone.0154472. eCollection 2016. PLoS One. 2016. PMID: 27128491 Free PMC article.
The most important decision faced by large-scale studies, such as those presently encountered in human genetics, is to distinguish between those tests that are true positives from those that are not. In the context of genetics, this entails the determination of g
The most important decision faced by large-scale studies, such as those presently encountered in human genetics, is to distinguish be …
Mining Retrospective Data for Virtual Prospective Drug Repurposing: L-DOPA and Age-related Macular Degeneration.
Brilliant MH, Vaziri K, Connor TB Jr, Schwartz SG, Carroll JJ, McCarty CA, Schrodi SJ, Hebbring SJ, Kishor KS, Flynn HW Jr, Moshfeghi AA, Moshfeghi DM, Fini ME, McKay BS. Brilliant MH, et al. Among authors: schrodi sj. Am J Med. 2016 Mar;129(3):292-8. doi: 10.1016/j.amjmed.2015.10.015. Epub 2015 Oct 30. Am J Med. 2016. PMID: 26524704 Free PMC article.
Complex host genetic susceptibility to Staphylococcus aureus infections.
Shukla SK, Rose W, Schrodi SJ. Shukla SK, et al. Among authors: schrodi sj. Trends Microbiol. 2015 Sep;23(9):529-36. doi: 10.1016/j.tim.2015.05.008. Epub 2015 Jun 22. Trends Microbiol. 2015. PMID: 26112911 Review.
Understanding of the host genetic susceptibility to carriage of, and infections, due to Staphylococcus aureus, a nosocomial pathogen, is still in its nascent stages. ...
Understanding of the host genetic susceptibility to carriage of, and infections, due to Staphylococcus aureus, a nosocomial pathogen, …
Differential Lipid Response to Statins Is Associated With Variants in the BUD13-APOA5 Gene Region.
OʼBrien SE, Schrodi SJ, Ye Z, Brilliant MH, Virani SS, Brautbar A. OʼBrien SE, et al. Among authors: schrodi sj. J Cardiovasc Pharmacol. 2015 Aug;66(2):183-8. doi: 10.1097/FJC.0000000000000261. J Cardiovasc Pharmacol. 2015. PMID: 25900265 Free PMC article.
Genetic variants within the BUD13-APOA5 gene region are known to be associated with high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) levels. ...
Genetic variants within the BUD13-APOA5 gene region are known to be associated with high-density lipoprotein cholesterol (HDL-C) and
Prevalence estimation for monogenic autosomal recessive diseases using population-based genetic data.
Schrodi SJ, DeBarber A, He M, Ye Z, Peissig P, Van Wormer JJ, Haws R, Brilliant MH, Steiner RD. Schrodi SJ, et al. Hum Genet. 2015 Jun;134(6):659-69. doi: 10.1007/s00439-015-1551-8. Epub 2015 Apr 19. Hum Genet. 2015. PMID: 25893794
Genetic methods can complement epidemiological surveys and clinical registries in determining prevalence of monogenic autosomal recessive diseases. Several large population-based genetic databases, such as the NHLBI GO Exome Sequencing Project, are now publically av
Genetic methods can complement epidemiological surveys and clinical registries in determining prevalence of monogenic autosomal reces
SeqHBase: a big data toolset for family based sequencing data analysis.
He M, Person TN, Hebbring SJ, Heinzen E, Ye Z, Schrodi SJ, McPherson EW, Lin SM, Peissig PL, Brilliant MH, O'Rawe J, Robison RJ, Lyon GJ, Wang K. He M, et al. Among authors: schrodi sj. J Med Genet. 2015 Apr;52(4):282-8. doi: 10.1136/jmedgenet-2014-102907. Epub 2015 Jan 13. J Med Genet. 2015. PMID: 25587064 Free PMC article.
CONCLUSIONS: These results demonstrate SeqHBase's high efficiency and scalability, which is necessary as WGS and WES are rapidly becoming standard methods to study the genetics of familial disorders....
CONCLUSIONS: These results demonstrate SeqHBase's high efficiency and scalability, which is necessary as WGS and WES are rapidly becoming st …
Use of an electronic medical record to create the marshfield clinic twin/multiple birth cohort.
Mayer J, Kitchner T, Ye Z, Zhou Z, He M, Schrodi SJ, Hebbring SJ. Mayer J, et al. Among authors: schrodi sj. Genet Epidemiol. 2014 Dec;38(8):692-8. doi: 10.1002/gepi.21855. Epub 2014 Sep 22. Genet Epidemiol. 2014. PMID: 25250975 Free PMC article.
Population-based genetic analyses, such as the Genome-Wide Association Study (GWAS), have proven powerful for describing the genetic complexities of common disease in epidemiologic research. ...An EMR system provides both a mechanism to identify potential twins and …
Population-based genetic analyses, such as the Genome-Wide Association Study (GWAS), have proven powerful for describing the genet
Phenome-wide association studies (PheWASs) for functional variants.
Ye Z, Mayer J, Ivacic L, Zhou Z, He M, Schrodi SJ, Page D, Brilliant MH, Hebbring SJ. Ye Z, et al. Among authors: schrodi sj. Eur J Hum Genet. 2015 Apr;23(4):523-9. doi: 10.1038/ejhg.2014.123. Epub 2014 Jul 30. Eur J Hum Genet. 2015. PMID: 25074467 Free PMC article.
The genome-wide association study (GWAS) is a powerful approach for studying the genetic complexities of human disease. Unfortunately, GWASs often fail to identify clinically significant associations and describing function can be a challenge. ...It is now possible to cond …
The genome-wide association study (GWAS) is a powerful approach for studying the genetic complexities of human disease. Unfortunately …
Genetic-based prediction of disease traits: prediction is very difficult, especially about the future.
Schrodi SJ, Mukherjee S, Shan Y, Tromp G, Sninsky JJ, Callear AP, Carter TC, Ye Z, Haines JL, Brilliant MH, Crane PK, Smelser DT, Elston RC, Weeks DE. Schrodi SJ, et al. Front Genet. 2014 Jun 2;5:162. doi: 10.3389/fgene.2014.00162. eCollection 2014. Front Genet. 2014. PMID: 24917882 Free PMC article. Review.
Translation of results from genetic findings to inform medical practice is a highly anticipated goal of human genetics. The aim of this paper is to review and discuss the role of genetics in medically-relevant prediction. Germline genetics presages dis …
Translation of results from genetic findings to inform medical practice is a highly anticipated goal of human genetics. The ai …
Genome wide association study of SNP-, gene-, and pathway-based approaches to identify genes influencing susceptibility to Staphylococcus aureus infections.
Ye Z, Vasco DA, Carter TC, Brilliant MH, Schrodi SJ, Shukla SK. Ye Z, et al. Among authors: schrodi sj. Front Genet. 2014 May 9;5:125. doi: 10.3389/fgene.2014.00125. eCollection 2014. Front Genet. 2014. PMID: 24847357 Free PMC article.
BACKGROUND: We conducted a genome-wide association study (GWAS) to identify specific genetic variants that underlie susceptibility to diseases caused by Staphylococcus aureus in humans. ...
BACKGROUND: We conducted a genome-wide association study (GWAS) to identify specific genetic variants that underlie susceptibility to …
A PheWAS approach in studying HLA-DRB1*1501.
Hebbring SJ, Schrodi SJ, Ye Z, Zhou Z, Page D, Brilliant MH. Hebbring SJ, et al. Among authors: schrodi sj. Genes Immun. 2013 Apr;14(3):187-91. doi: 10.1038/gene.2013.2. Epub 2013 Feb 7. Genes Immun. 2013. PMID: 23392276 Free PMC article.
HLA-DRB1 codes for a major histocompatibility complex class II cell surface receptor. Genetic variants in and around this gene have been linked to numerous autoimmune diseases. ...Utilizing electronic health records and 4235 individuals within Marshfield Clinic's Personali …
HLA-DRB1 codes for a major histocompatibility complex class II cell surface receptor. Genetic variants in and around this gene have b …
Genetic evidence of PTPN22 effects on chronic lymphocytic leukemia.
Hebbring SJ, Slager SL, Epperla N, Mazza JJ, Ye Z, Zhou Z, Achenbach SJ, Vasco DA, Call TG, Rabe KG, Kay NE, Caporaso NE, Lanasa MC, Camp NJ, Strom SS, Goldin LR, Cerhan JR, Brilliant MH, Schrodi SJ. Hebbring SJ, et al. Among authors: schrodi sj. Blood. 2013 Jan 3;121(1):237-8. doi: 10.1182/blood-2012-08-450221. Blood. 2013. PMID: 23287625 Free PMC article. No abstract available.
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.
Tsoi LC, Spain SL, Knight J, Ellinghaus E, Stuart PE, Capon F, Ding J, Li Y, Tejasvi T, Gudjonsson JE, Kang HM, Allen MH, McManus R, Novelli G, Samuelsson L, Schalkwijk J, Ståhle M, Burden AD, Smith CH, Cork MJ, Estivill X, Bowcock AM, Krueger GG, Weger W, Worthington J, Tazi-Ahnini R, Nestle FO, Hayday A, Hoffmann P, Winkelmann J, Wijmenga C, Langford C, Edkins S, Andrews R, Blackburn H, Strange A, Band G, Pearson RD, Vukcevic D, Spencer CC, Deloukas P, Mrowietz U, Schreiber S, Weidinger S, Koks S, Kingo K, Esko T, Metspalu A, Lim HW, Voorhees JJ, Weichenthal M, Wichmann HE, Chandran V, Rosen CF, Rahman P, Gladman DD, Griffiths CE, Reis A, Kere J; Collaborative Association Study of Psoriasis (CASP); Genetic Analysis of Psoriasis Consortium; Psoriasis Association Genetics Extension; Wellcome Trust Case Control Consortium 2; Nair RP, Franke A, Barker JN, Abecasis GR, Elder JT, Trembath RC. Tsoi LC, et al. Nat Genet. 2012 Dec;44(12):1341-8. doi: 10.1038/ng.2467. Epub 2012 Nov 11. Nat Genet. 2012. PMID: 23143594 Free PMC article.
To gain further insight into the genetic architecture of psoriasis, we conducted a meta-analysis of 3 genome-wide association studies (GWAS) and 2 independent data sets genotyped on the Immunochip, including 10,588 cases and 22,806 controls. ...These results portend a bett …
To gain further insight into the genetic architecture of psoriasis, we conducted a meta-analysis of 3 genome-wide association studies …
Multiple Loci within the major histocompatibility complex confer risk of psoriasis.
Feng BJ, Sun LD, Soltani-Arabshahi R, Bowcock AM, Nair RP, Stuart P, Elder JT, Schrodi SJ, Begovich AB, Abecasis GR, Zhang XJ, Callis-Duffin KP, Krueger GG, Goldgar DE. Feng BJ, et al. Among authors: schrodi sj. PLoS Genet. 2009 Aug;5(8):e1000606. doi: 10.1371/journal.pgen.1000606. Epub 2009 Aug 14. PLoS Genet. 2009. PMID: 19680446 Free PMC article.
Association between IL13 polymorphisms and psoriatic arthritis is modified by smoking.
Duffin KC, Freeny IC, Schrodi SJ, Wong B, Feng BJ, Soltani-Arabshahi R, Rakkhit T, Goldgar DE, Krueger GG. Duffin KC, et al. Among authors: schrodi sj. J Invest Dermatol. 2009 Dec;129(12):2777-83. doi: 10.1038/jid.2009.169. Epub 2009 Jun 25. J Invest Dermatol. 2009. PMID: 19554022 Free article.
Genetic and environmental factors influence the development of psoriasis (Ps) and psoriatic arthritis (PsA). ...
Genetic and environmental factors influence the development of psoriasis (Ps) and psoriatic arthritis (PsA). ...
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.
Nair RP, Duffin KC, Helms C, Ding J, Stuart PE, Goldgar D, Gudjonsson JE, Li Y, Tejasvi T, Feng BJ, Ruether A, Schreiber S, Weichenthal M, Gladman D, Rahman P, Schrodi SJ, Prahalad S, Guthery SL, Fischer J, Liao W, Kwok PY, Menter A, Lathrop GM, Wise CA, Begovich AB, Voorhees JJ, Elder JT, Krueger GG, Bowcock AM, Abecasis GR; Collaborative Association Study of Psoriasis. Nair RP, et al. Among authors: schrodi sj. Nat Genet. 2009 Feb;41(2):199-204. doi: 10.1038/ng.311. Epub 2009 Jan 25. Nat Genet. 2009. PMID: 19169254 Free PMC article.

Our results provide strong support for the association of at least seven genetic loci and psoriasis (each with combined P < 5 x 10(-8)). Loci with confirmed association include HLA-C, three genes involved in IL-23 signaling (IL23A, IL23R, IL12B), two genes that act down

Our results provide strong support for the association of at least seven genetic loci and psoriasis (each with combined P < 5 x 10

Further genetic evidence for three psoriasis-risk genes: ADAM33, CDKAL1, and PTPN22.
Li Y, Liao W, Chang M, Schrodi SJ, Bui N, Catanese JJ, Poon A, Matsunami N, Callis-Duffin KP, Leppert MF, Bowcock AM, Kwok PY, Krueger GG, Begovich AB. Li Y, et al. Among authors: schrodi sj. J Invest Dermatol. 2009 Mar;129(3):629-34. doi: 10.1038/jid.2008.297. Epub 2008 Oct 16. J Invest Dermatol. 2009. PMID: 18923449 Free PMC article.
Predisposition to psoriasis is known to be affected by genetic variation in HLA-C, IL12B, and IL23R, and although other psoriasis-associated variants have been identified, incontrovertible statistical evidence for these markers has not yet been obtained. ...
Predisposition to psoriasis is known to be affected by genetic variation in HLA-C, IL12B, and IL23R, and although other psoriasis-ass …
Genome-wide association scan in psoriasis: new insights into chronic inflammatory disease.
Schrodi SJ. Schrodi SJ. Expert Rev Clin Immunol. 2008 Sep;4(5):565-71. doi: 10.1586/1744666X.4.5.565. Expert Rev Clin Immunol. 2008. PMID: 20476959
These results, while still preliminary, may substantially expand our knowledge of psoriasis and psoriatic arthritis genetics, opening new avenues of chronic inflammatory disease research....
These results, while still preliminary, may substantially expand our knowledge of psoriasis and psoriatic arthritis genetics, opening …
Detailed genetic characterization of the interleukin-23 receptor in psoriasis.
Garcia VE, Chang M, Brandon R, Li Y, Matsunami N, Callis-Duffin KP, Civello D, Rowland CM, Bui N, Catanese JJ, Krueger GG, Leppert MF, Begovich AB, Schrodi SJ. Garcia VE, et al. Among authors: schrodi sj. Genes Immun. 2008 Sep;9(6):546-55. doi: 10.1038/gene.2008.55. Epub 2008 Jul 24. Genes Immun. 2008. PMID: 18650833
Further, this work is essential to lay the foundation for the role of IL23R genetics in response to pharmaceutical therapy and dosage....
Further, this work is essential to lay the foundation for the role of IL23R genetics in response to pharmaceutical therapy and dosage …
A large-scale rheumatoid arthritis genetic study identifies association at chromosome 9q33.2.
Chang M, Rowland CM, Garcia VE, Schrodi SJ, Catanese JJ, van der Helm-van Mil AH, Ardlie KG, Amos CI, Criswell LA, Kastner DL, Gregersen PK, Kurreeman FA, Toes RE, Huizinga TW, Seldin MF, Begovich AB. Chang M, et al. Among authors: schrodi sj. PLoS Genet. 2008 Jun 27;4(6):e1000107. doi: 10.1371/journal.pgen.1000107. PLoS Genet. 2008. PMID: 18648537 Free PMC article.
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease affecting both joints and extra-articular tissues. Although some genetic risk factors for RA are well-established, most notably HLA-DRB1 and PTPN22, these markers do not fully account for the observed heri …
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease affecting both joints and extra-articular tissues. Although some gene
Neither replication nor simulation supports a role for the axon guidance pathway in the genetics of Parkinson's disease.
Li Y, Rowland C, Xiromerisiou G, Lagier RJ, Schrodi SJ, Dradiotis E, Ross D, Bui N, Catanese J, Aggelakis K, Grupe A, Hadjigeorgiou G. Li Y, et al. Among authors: schrodi sj. PLoS One. 2008 Jul 16;3(7):e2707. doi: 10.1371/journal.pone.0002707. PLoS One. 2008. PMID: 18628988 Free PMC article.
Susceptibility to sporadic Parkinson's disease (PD) is thought to be influenced by both genetic and environmental factors and their interaction with each other. ...Together, these results challenge the robustness of the reported panel of genetic markers to predict P …
Susceptibility to sporadic Parkinson's disease (PD) is thought to be influenced by both genetic and environmental factors and their i …
The 5q31 variants associated with psoriasis and Crohn's disease are distinct.
Li Y, Chang M, Schrodi SJ, Callis-Duffin KP, Matsunami N, Civello D, Bui N, Catanese JJ, Leppert MF, Krueger GG, Begovich AB. Li Y, et al. Among authors: schrodi sj. Hum Mol Genet. 2008 Oct 1;17(19):2978-85. doi: 10.1093/hmg/ddn196. Epub 2008 Jul 9. Hum Mol Genet. 2008. PMID: 18614543 Free PMC article.
Predisposition to psoriasis is known to be affected by genetic variation in HLA-C, IL12B and IL23R, but other genetic risk factors also exist. ...The aim of this study was to assess whether other variants in the 5q31 region are causal to these SNPs or make independe …
Predisposition to psoriasis is known to be affected by genetic variation in HLA-C, IL12B and IL23R, but other genetic risk fac …
The inflammatory disease-associated variants in IL12B and IL23R are not associated with rheumatoid arthritis.
Chang M, Saiki RK, Cantanese JJ, Lew D, van der Helm-van Mil AH, Toes RE, Huizinga TW, Ardlie KG, Criswell LA, Seldin MF, Amos CI, Kastner DL, Gregersen PK, Schrodi SJ, Begovich AB. Chang M, et al. Among authors: schrodi sj. Arthritis Rheum. 2008 Jun;58(6):1877-81. doi: 10.1002/art.23492. Arthritis Rheum. 2008. PMID: 18512797 Free PMC article. No abstract available.
Variants in the 5q31 cytokine gene cluster are associated with psoriasis.
Chang M, Li Y, Yan C, Callis-Duffin KP, Matsunami N, Garcia VE, Cargill M, Civello D, Bui N, Catanese JJ, Leppert MF, Krueger GG, Begovich AB, Schrodi SJ. Chang M, et al. Among authors: schrodi sj. Genes Immun. 2008 Mar;9(2):176-81. doi: 10.1038/sj.gene.6364451. Epub 2007 Dec 13. Genes Immun. 2008. PMID: 18075513
A multitiered genetic association study of 25 215 single-nucleotide polymorphisms (SNPs) in three case-control sample sets (1446 patients and 1432 controls) identified three IL13-linked SNPs (rs1800925, rs20541 and rs848) associated with psoriasis. ...Haplotype analyses id …
A multitiered genetic association study of 25 215 single-nucleotide polymorphisms (SNPs) in three case-control sample sets (1446 pati …
A candidate gene approach identifies the TRAF1/C5 region as a risk factor for rheumatoid arthritis.
Kurreeman FA, Padyukov L, Marques RB, Schrodi SJ, Seddighzadeh M, Stoeken-Rijsbergen G, van der Helm-van Mil AH, Allaart CF, Verduyn W, Houwing-Duistermaat J, Alfredsson L, Begovich AB, Klareskog L, Huizinga TW, Toes RE. Kurreeman FA, et al. Among authors: schrodi sj. PLoS Med. 2007 Sep;4(9):e278. doi: 10.1371/journal.pmed.0040278. PLoS Med. 2007. PMID: 17880261 Free PMC article.
The disease results from the interplay between an individual's genetic background and unknown environmental triggers. Although human leukocyte antigens (HLAs) account for approximately 30% of the heritable risk, the identities of non-HLA genes explaining the remainder of t …
The disease results from the interplay between an individual's genetic background and unknown environmental triggers. Although human …
A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes.
Cargill M, Schrodi SJ, Chang M, Garcia VE, Brandon R, Callis KP, Matsunami N, Ardlie KG, Civello D, Catanese JJ, Leong DU, Panko JM, McAllister LB, Hansen CB, Papenfuss J, Prescott SM, White TJ, Leppert MF, Krueger GG, Begovich AB. Cargill M, et al. Among authors: schrodi sj. Am J Hum Genet. 2007 Feb;80(2):273-90. doi: 10.1086/511051. Epub 2006 Dec 21. Am J Hum Genet. 2007. PMID: 17236132 Free PMC article.
Pairwise linkage disequilibrium under disease models.
Schrodi SJ, Garcia VE, Rowland C, Jones HB. Schrodi SJ, et al. Eur J Hum Genet. 2007 Feb;15(2):212-20. doi: 10.1038/sj.ejhg.5201731. Epub 2006 Nov 15. Eur J Hum Genet. 2007. PMID: 17106449
Many genetic studies of disease association rely heavily on linkage disequilibrium (LD) patterns between pairs of markers to detect susceptibility markers. This is true of large-scale positional mapping approaches as well as haplotype construction, selection of tagging sin …
Many genetic studies of disease association rely heavily on linkage disequilibrium (LD) patterns between pairs of markers to detect s …
Genetic evidence for ubiquitin-specific proteases USP24 and USP40 as candidate genes for late-onset Parkinson disease.
Li Y, Schrodi S, Rowland C, Tacey K, Catanese J, Grupe A. Li Y, et al. Among authors: schrodi s. Hum Mutat. 2006 Oct;27(10):1017-23. doi: 10.1002/humu.20382. Hum Mutat. 2006. PMID: 16917932
Linkage studies have defined susceptibility regions for late-onset Parkinson disease (PD) on chromosomes 1 and 2, but specific genetic variants have not been definitively identified. Here we report the results of a case-control study to identify disease-associated single n …
Linkage studies have defined susceptibility regions for late-onset Parkinson disease (PD) on chromosomes 1 and 2, but specific genetic
Identification of two gene variants associated with risk of advanced fibrosis in patients with chronic hepatitis C.
Huang H, Shiffman ML, Cheung RC, Layden TJ, Friedman S, Abar OT, Yee L, Chokkalingam AP, Schrodi SJ, Chan J, Catanese JJ, Leong DU, Ross D, Hu X, Monto A, McAllister LB, Broder S, White T, Sninsky JJ, Wright TL. Huang H, et al. Among authors: schrodi sj. Gastroenterology. 2006 May;130(6):1679-87. doi: 10.1053/j.gastro.2006.02.032. Epub 2006 Mar 6. Gastroenterology. 2006. PMID: 16697732
BACKGROUND & AIMS: Previously identified clinical risk factors such as sex, alcohol consumption, and age at infection do not accurately predict which patients with chronic hepatitis C (CHC) will develop advanced fibrosis (bridging fibrosis and cirrhosis). The aim of this stud …
BACKGROUND & AIMS: Previously identified clinical risk factors such as sex, alcohol consumption, and age at infection do not accurately …
A probabilistic approach to large-scale association scans: a semi-Bayesian method to detect disease-predisposing alleles.
Schrodi SJ. Schrodi SJ. Stat Appl Genet Mol Biol. 2005;4:Article31. doi: 10.2202/1544-6115.1168. Epub 2005 Nov 1. Stat Appl Genet Mol Biol. 2005. PMID: 16646850
This paper discusses a probabilistic methodology for making disease-mapping inferences in large-scale case-control genetic studies. The semi-Bayesian approach promoted compares the probability of the observed data under disease hypotheses to the probability of the data und …
This paper discusses a probabilistic methodology for making disease-mapping inferences in large-scale case-control genetic studies. T …
PTPN22 genetic variation: evidence for multiple variants associated with rheumatoid arthritis.
Carlton VE, Hu X, Chokkalingam AP, Schrodi SJ, Brandon R, Alexander HC, Chang M, Catanese JJ, Leong DU, Ardlie KG, Kastner DL, Seldin MF, Criswell LA, Gregersen PK, Beasley E, Thomson G, Amos CI, Begovich AB. Carlton VE, et al. Among authors: schrodi sj. Am J Hum Genet. 2005 Oct;77(4):567-81. doi: 10.1086/468189. Epub 2005 Aug 10. Am J Hum Genet. 2005. PMID: 16175503 Free PMC article.
The minor allele of the R620W missense single-nucleotide polymorphism (SNP) (rs2476601) in the hematopoietic-specific protein tyrosine phosphatase gene, PTPN22, has been associated with multiple autoimmune diseases, including rheumatoid arthritis (RA). These genetic data, …
The minor allele of the R620W missense single-nucleotide polymorphism (SNP) (rs2476601) in the hematopoietic-specific protein tyrosine phosp …
Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family.
Li Y, Nowotny P, Holmans P, Smemo S, Kauwe JS, Hinrichs AL, Tacey K, Doil L, van Luchene R, Garcia V, Rowland C, Schrodi S, Leong D, Gogic G, Chan J, Cravchik A, Ross D, Lau K, Kwok S, Chang SY, Catanese J, Sninsky J, White TJ, Hardy J, Powell J, Lovestone S, Morris JC, Thal L, Owen M, Williams J, Goate A, Grupe A. Li Y, et al. Among authors: schrodi s. Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15688-93. doi: 10.1073/pnas.0403535101. Epub 2004 Oct 26. Proc Natl Acad Sci U S A. 2004. PMID: 15507493 Free PMC article.
Although several genes have been implicated in the development of the early-onset autosomal dominant form of Alzheimer's disease (AD), the genetics of late-onset AD (LOAD) is complex. Loci on several chromosomes have been linked to the disease, but so far only the apolipop …
Although several genes have been implicated in the development of the early-onset autosomal dominant form of Alzheimer's disease (AD), the …
Selecting tagging SNPs for association studies using power calculations from genotype data.
Hu X, Schrodi SJ, Ross DA, Cargill M. Hu X, et al. Among authors: schrodi sj. Hum Hered. 2004;57(3):156-70. doi: 10.1159/000079246. Hum Hered. 2004. PMID: 15297809
Recent studies have indicated that linkage disequilibrium (LD) between single nucleotide polymorphism (SNP) markers can be used to derive a reduced set of tagging SNPs (tSNPs) for genetic association studies. Previous strategies for identifying tSNPs have focused on LD mea …
Recent studies have indicated that linkage disequilibrium (LD) between single nucleotide polymorphism (SNP) markers can be used to derive a …
Association of ABCA1 with late-onset Alzheimer's disease is not observed in a case-control study.
Li Y, Tacey K, Doil L, van Luchene R, Garcia V, Rowland C, Schrodi S, Leong D, Lau K, Catanese J, Sninsky J, Nowotny P, Holmans P, Hardy J, Powell J, Lovestone S, Thal L, Owen M, Williams J, Goate A, Grupe A. Li Y, et al. Among authors: schrodi s. Neurosci Lett. 2004 Aug 19;366(3):268-71. doi: 10.1016/j.neulet.2004.05.047. Neurosci Lett. 2004. PMID: 15288432
Genetic association of ABCA1 or the ATP-binding cassette A1 transporter with late-onset Alzheimer's disease (LOAD) has recently been proposed for a haplotype comprised of three single nucleotide polymorphisms (SNPs). ...
Genetic association of ABCA1 or the ATP-binding cassette A1 transporter with late-onset Alzheimer's disease (LOAD) has recently been
A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis.
Begovich AB, Carlton VE, Honigberg LA, Schrodi SJ, Chokkalingam AP, Alexander HC, Ardlie KG, Huang Q, Smith AM, Spoerke JM, Conn MT, Chang M, Chang SY, Saiki RK, Catanese JJ, Leong DU, Garcia VE, McAllister LB, Jeffery DA, Lee AT, Batliwalla F, Remmers E, Criswell LA, Seldin MF, Kastner DL, Amos CI, Sninsky JJ, Gregersen PK. Begovich AB, et al. Among authors: schrodi sj. Am J Hum Genet. 2004 Aug;75(2):330-7. doi: 10.1086/422827. Epub 2004 Jun 18. Am J Hum Genet. 2004. PMID: 15208781 Free PMC article.